Journal: Frontiers in Public Health
Article Title: Biological effects in normal human fibroblasts following chronic and acute irradiation with both low- and high-LET radiation
doi: 10.3389/fpubh.2024.1404748
Figure Lengend Snippet: Dose-response curves for the micronuclei yield (micronucleus frequency/BNC vs. dose) in confluent AG1522 cells irradiated with different doses of gamma rays (0.4, 0.9, 1.4, and 2.3 Gy) and alpha particles (0.1, 0.4, and 0.9 Gy), at a high dose rate (of ~40,200 and 4,980 mGy/h for gamma rays and alpha particles, respectively) and at a low dose rate (~18 mGy/h for both gamma rays and alpha particles). Data points represent the means of at least three independent experiments with ~1,000 BNC scored per experiment; the error bars represent the standard error of the mean. The statistical difference between the results obtained at the same dose for chronic and acute gamma exposures was analyzed using the student's t -test. The statistical difference between the results obtained at the same dose for chronic and acute alpha exposures was analyzed using the student's t -test. Values of p < 0.05 (*) and p < 0.01 (**) were considered as statistically significant.
Article Snippet: AG1522 normal human foreskin fibroblasts were obtained from the Genetic Cell Repository at the Coriell Institute for Medical Research (Camden, NJ).
Techniques: Irradiation