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htr  (ATCC)


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    ATCC htr
    CBNK-EVs rapidly impair ZIKV infectivity and protect host cells. (a) Multiplex immunohistochemical analysis of ZIKV infection in neural progenitor cells. Co-staining for Nestin (neural progenitor cells, green) and ZIKV E protein (red) was performed, and double-positive cells were quantified across six random fields, mean ± SD, ∗P < 0.05. Scale bar, 20 μm. (b) KEGG pathway enrichment bubble plot from <t>RNA-seq</t> <t>of</t> <t>HTR-8/Svneo</t> cells treated with CBNK-EVs (3 × 10 11 particles/mL, 10 μl) and ZIKV (MOI = 1) for 1 h. (c) GSEA analysis of transcriptomic data from HTR-8/Svneo cells. (d) Western blot analysis of ZIKV E and ZIKV NS5 protein levels after co-incubation of ZIKV particles with CBNK-EVs for the indicated time periods (0–30 min) prior to infection. (e) The abundance of NK cell-associated proteins in CBNK-EVs. ∗P < 0.05 (one-way ANOVA).
    Htr, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 875 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/htr/pmc12887259-266-5-10?v=ATCC
    Average 97 stars, based on 875 article reviews
    htr - by Bioz Stars, 2026-07
    97/100 stars

    Images

    1) Product Images from "Cord blood natural killer cell-derived extracellular vesicles inhibit Zika virus infectivity through ITGB2/perforin-mediated envelope disruption in vitro and in vivo"

    Article Title: Cord blood natural killer cell-derived extracellular vesicles inhibit Zika virus infectivity through ITGB2/perforin-mediated envelope disruption in vitro and in vivo

    Journal: Bioactive Materials

    doi: 10.1016/j.bioactmat.2026.01.030

    CBNK-EVs rapidly impair ZIKV infectivity and protect host cells. (a) Multiplex immunohistochemical analysis of ZIKV infection in neural progenitor cells. Co-staining for Nestin (neural progenitor cells, green) and ZIKV E protein (red) was performed, and double-positive cells were quantified across six random fields, mean ± SD, ∗P < 0.05. Scale bar, 20 μm. (b) KEGG pathway enrichment bubble plot from RNA-seq of HTR-8/Svneo cells treated with CBNK-EVs (3 × 10 11 particles/mL, 10 μl) and ZIKV (MOI = 1) for 1 h. (c) GSEA analysis of transcriptomic data from HTR-8/Svneo cells. (d) Western blot analysis of ZIKV E and ZIKV NS5 protein levels after co-incubation of ZIKV particles with CBNK-EVs for the indicated time periods (0–30 min) prior to infection. (e) The abundance of NK cell-associated proteins in CBNK-EVs. ∗P < 0.05 (one-way ANOVA).
    Figure Legend Snippet: CBNK-EVs rapidly impair ZIKV infectivity and protect host cells. (a) Multiplex immunohistochemical analysis of ZIKV infection in neural progenitor cells. Co-staining for Nestin (neural progenitor cells, green) and ZIKV E protein (red) was performed, and double-positive cells were quantified across six random fields, mean ± SD, ∗P < 0.05. Scale bar, 20 μm. (b) KEGG pathway enrichment bubble plot from RNA-seq of HTR-8/Svneo cells treated with CBNK-EVs (3 × 10 11 particles/mL, 10 μl) and ZIKV (MOI = 1) for 1 h. (c) GSEA analysis of transcriptomic data from HTR-8/Svneo cells. (d) Western blot analysis of ZIKV E and ZIKV NS5 protein levels after co-incubation of ZIKV particles with CBNK-EVs for the indicated time periods (0–30 min) prior to infection. (e) The abundance of NK cell-associated proteins in CBNK-EVs. ∗P < 0.05 (one-way ANOVA).

    Techniques Used: Infection, Multiplex Assay, Immunohistochemical staining, Staining, RNA Sequencing, Western Blot, Incubation



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    Image Search Results


    CBNK-EVs rapidly impair ZIKV infectivity and protect host cells. (a) Multiplex immunohistochemical analysis of ZIKV infection in neural progenitor cells. Co-staining for Nestin (neural progenitor cells, green) and ZIKV E protein (red) was performed, and double-positive cells were quantified across six random fields, mean ± SD, ∗P < 0.05. Scale bar, 20 μm. (b) KEGG pathway enrichment bubble plot from RNA-seq of HTR-8/Svneo cells treated with CBNK-EVs (3 × 10 11 particles/mL, 10 μl) and ZIKV (MOI = 1) for 1 h. (c) GSEA analysis of transcriptomic data from HTR-8/Svneo cells. (d) Western blot analysis of ZIKV E and ZIKV NS5 protein levels after co-incubation of ZIKV particles with CBNK-EVs for the indicated time periods (0–30 min) prior to infection. (e) The abundance of NK cell-associated proteins in CBNK-EVs. ∗P < 0.05 (one-way ANOVA).

    Journal: Bioactive Materials

    Article Title: Cord blood natural killer cell-derived extracellular vesicles inhibit Zika virus infectivity through ITGB2/perforin-mediated envelope disruption in vitro and in vivo

    doi: 10.1016/j.bioactmat.2026.01.030

    Figure Lengend Snippet: CBNK-EVs rapidly impair ZIKV infectivity and protect host cells. (a) Multiplex immunohistochemical analysis of ZIKV infection in neural progenitor cells. Co-staining for Nestin (neural progenitor cells, green) and ZIKV E protein (red) was performed, and double-positive cells were quantified across six random fields, mean ± SD, ∗P < 0.05. Scale bar, 20 μm. (b) KEGG pathway enrichment bubble plot from RNA-seq of HTR-8/Svneo cells treated with CBNK-EVs (3 × 10 11 particles/mL, 10 μl) and ZIKV (MOI = 1) for 1 h. (c) GSEA analysis of transcriptomic data from HTR-8/Svneo cells. (d) Western blot analysis of ZIKV E and ZIKV NS5 protein levels after co-incubation of ZIKV particles with CBNK-EVs for the indicated time periods (0–30 min) prior to infection. (e) The abundance of NK cell-associated proteins in CBNK-EVs. ∗P < 0.05 (one-way ANOVA).

    Article Snippet: Vero E6, BHK21, 293T and HTR-8/Svneo cells were purchased from ATCC.

    Techniques: Infection, Multiplex Assay, Immunohistochemical staining, Staining, RNA Sequencing, Western Blot, Incubation