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hdac2 primary antibody  (Proteintech)


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    Proteintech hdac2 primary antibody
    Hdac2 Primary Antibody, supplied by Proteintech, used in various techniques. Bioz Stars score: 95/100, based on 110 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/hdac2 primary antibody/product/Proteintech
    Average 95 stars, based on 110 article reviews
    hdac2 primary antibody - by Bioz Stars, 2026-02
    95/100 stars

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    Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased <t>HDAC2</t> mRNA expression (n=17 donors, *p<0.05). ( B ) Dopamine significantly increased HDAC6 mRNA expression (n=14 donors, *p<0.05). ( C ) KAT2A mRNA expression was not significantly altered by dopamine treatment(n=17 donors). ( D ) KDM6B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).
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    Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased <t>HDAC2</t> mRNA expression (n=17 donors, *p<0.05). ( B ) Dopamine significantly increased HDAC6 mRNA expression (n=14 donors, *p<0.05). ( C ) KAT2A mRNA expression was not significantly altered by dopamine treatment(n=17 donors). ( D ) KDM6B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).
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    Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased <t>HDAC2</t> mRNA expression (n=17 donors, *p<0.05). ( B ) Dopamine significantly increased HDAC6 mRNA expression (n=14 donors, *p<0.05). ( C ) KAT2A mRNA expression was not significantly altered by dopamine treatment(n=17 donors). ( D ) KDM6B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).
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    Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased <t>HDAC2</t> mRNA expression (n=17 donors, *p<0.05). ( B ) Dopamine significantly increased HDAC6 mRNA expression (n=14 donors, *p<0.05). ( C ) KAT2A mRNA expression was not significantly altered by dopamine treatment(n=17 donors). ( D ) KDM6B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).
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    Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased <t>HDAC2</t> mRNA expression (n=17 donors, *p<0.05). ( B ) Dopamine significantly increased HDAC6 mRNA expression (n=14 donors, *p<0.05). ( C ) KAT2A mRNA expression was not significantly altered by dopamine treatment(n=17 donors). ( D ) KDM6B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).
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    Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased <t>HDAC2</t> mRNA expression (n=17 donors, *p<0.05). ( B ) Dopamine significantly increased HDAC6 mRNA expression (n=14 donors, *p<0.05). ( C ) KAT2A mRNA expression was not significantly altered by dopamine treatment(n=17 donors). ( D ) KDM6B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).
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    Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased <t>HDAC2</t> mRNA expression (n=17 donors, *p<0.05). ( B ) Dopamine significantly increased HDAC6 mRNA expression (n=14 donors, *p<0.05). ( C ) KAT2A mRNA expression was not significantly altered by dopamine treatment(n=17 donors). ( D ) KDM6B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).
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    (A) Immunoblotting analysis of the indicated HDACs in HeLa cells infected with HSV-1 (MOI = 1) for the indicated time points. (B) Immunoblotting analysis of the indicated HDACs in 3D4/21 cells infected with PRV-QXX (MOI = 1) for the indicated time points. (C and D) qRT-PCR analysis of HDAC1 and <t>HDAC2</t> mRNA levels in HSV-1-infected HeLa cells (C) or PRV-QXX-infected 3D4/21 cells (D) (MOI = 1). Data are mean ± SEM; n = 3. ** P < 0.01, *** P < 0.001. (E) Immunoblotting of the indicated proteins in HeLa cells from infected with HSV-1 (MOI = 1) for the indicated time points. (F) Immunoblotting of the indicated proteins in 3D4/21 cells from infected with PRV-QXX (MOI = 1) for the indicated time points. (G) Immunoblotting analysis of the indicated proteins in liver tissues from mice mock-infected or infected with HSV-1 (1 × 10⁶ pfu per mouse) at 5 days post-infection (n = 3).
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    (A) Immunoblotting analysis of the indicated HDACs in HeLa cells infected with HSV-1 (MOI = 1) for the indicated time points. (B) Immunoblotting analysis of the indicated HDACs in 3D4/21 cells infected with PRV-QXX (MOI = 1) for the indicated time points. (C and D) qRT-PCR analysis of HDAC1 and <t>HDAC2</t> mRNA levels in HSV-1-infected HeLa cells (C) or PRV-QXX-infected 3D4/21 cells (D) (MOI = 1). Data are mean ± SEM; n = 3. ** P < 0.01, *** P < 0.001. (E) Immunoblotting of the indicated proteins in HeLa cells from infected with HSV-1 (MOI = 1) for the indicated time points. (F) Immunoblotting of the indicated proteins in 3D4/21 cells from infected with PRV-QXX (MOI = 1) for the indicated time points. (G) Immunoblotting analysis of the indicated proteins in liver tissues from mice mock-infected or infected with HSV-1 (1 × 10⁶ pfu per mouse) at 5 days post-infection (n = 3).
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    Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased HDAC2 mRNA expression (n=17 donors, *p<0.05). ( B ) Dopamine significantly increased HDAC6 mRNA expression (n=14 donors, *p<0.05). ( C ) KAT2A mRNA expression was not significantly altered by dopamine treatment(n=17 donors). ( D ) KDM6B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).

    Journal: bioRxiv

    Article Title: Epigenetic Regulation of Inflammation by Dopamine in Primary Human Macrophages

    doi: 10.64898/2026.01.21.700899

    Figure Lengend Snippet: Primary human monocyte-derived macrophages (hMDM) were treated with dopamine (10 -6 M) for 3 hours, and gene expression was assessed by qPCR. ( A ) Dopamine significantly increased HDAC2 mRNA expression (n=17 donors, *p<0.05). ( B ) Dopamine significantly increased HDAC6 mRNA expression (n=14 donors, *p<0.05). ( C ) KAT2A mRNA expression was not significantly altered by dopamine treatment(n=17 donors). ( D ) KDM6B mRNA expression was not significantly altered by dopamine treatment (n=17 donors).

    Article Snippet: TaqMan Fast Universal Master Mix, and PCR assay probes for DRD1-5 (Hs00265245_s1, Hs00241436_m1, Hs00364455_m1, Hs00609526_m1, Hs00361234_s1), IL1B (Hs01555410_m1), DNMT1 (Hs00945875_m1), DNMT3A (Hs01027166_m1), DNMT3B (Hs00171876_m1), TET2 (Hs00325999_m1), HDAC2 (Hs00231032_m1), HDAC6 (Hs00997427_m1), KDM6B (Hs00996325_g1), KAT2A (Hs00904943_gH), and 18S (4319413E) genes were purchased from Applied Biosystems.

    Techniques: Derivative Assay, Gene Expression, Expressing

    Data from were stratified by donor sex and age to assess potential sources of inter-donor variability. ( A ) Dopamine significantly increased HDAC2 mRNA expression in hMDMs from female donors (n=10, *p<0.05) but not male donors (n=7). ( B ) Dopamine treatment showed an increasing trend in HDAC6 expression in male hMDMs (n=9; p=0.0742) and a non-significant increase in female hMDMs (n=5). Dopamine treatment did not reveal sex-associated differences in ( C ) KAT2A or ( D ) KDM6B gene expression (n=17 donors each). ( E ) Dopamine treatment showed an increasing trend in HDAC2 expression in donors under 40 years of age (n=8, p=0.0547), but not in donors aged 40 years or older (n=9). No age-associated differences were observed for dopamine-induced changes in ( F ) HDAC6 (n=14), ( G ) KAT2A (n=17), or ( H ) KDM6B (n=17) expression.

    Journal: bioRxiv

    Article Title: Epigenetic Regulation of Inflammation by Dopamine in Primary Human Macrophages

    doi: 10.64898/2026.01.21.700899

    Figure Lengend Snippet: Data from were stratified by donor sex and age to assess potential sources of inter-donor variability. ( A ) Dopamine significantly increased HDAC2 mRNA expression in hMDMs from female donors (n=10, *p<0.05) but not male donors (n=7). ( B ) Dopamine treatment showed an increasing trend in HDAC6 expression in male hMDMs (n=9; p=0.0742) and a non-significant increase in female hMDMs (n=5). Dopamine treatment did not reveal sex-associated differences in ( C ) KAT2A or ( D ) KDM6B gene expression (n=17 donors each). ( E ) Dopamine treatment showed an increasing trend in HDAC2 expression in donors under 40 years of age (n=8, p=0.0547), but not in donors aged 40 years or older (n=9). No age-associated differences were observed for dopamine-induced changes in ( F ) HDAC6 (n=14), ( G ) KAT2A (n=17), or ( H ) KDM6B (n=17) expression.

    Article Snippet: TaqMan Fast Universal Master Mix, and PCR assay probes for DRD1-5 (Hs00265245_s1, Hs00241436_m1, Hs00364455_m1, Hs00609526_m1, Hs00361234_s1), IL1B (Hs01555410_m1), DNMT1 (Hs00945875_m1), DNMT3A (Hs01027166_m1), DNMT3B (Hs00171876_m1), TET2 (Hs00325999_m1), HDAC2 (Hs00231032_m1), HDAC6 (Hs00997427_m1), KDM6B (Hs00996325_g1), KAT2A (Hs00904943_gH), and 18S (4319413E) genes were purchased from Applied Biosystems.

    Techniques: Expressing, Gene Expression

    Donors from were combined with an independent archival cohort to assess correlations between dopamine receptor expression and epigenetic enzyme expression by qPCR. DRD1 expression was significantly correlated with ( A ) HDAC2 (n=28, **p<0.01), ( B ) HDAC6 (n=25, **p<0.01), ( C ) KAT2A (n=28, **p<0.01), and ( D ) KDM6B expression (n=28, ***p<0.001). DRD5 expression was significantly correlated with ( E ) HDAC2 (n=28, *p<0.01), ( F ) HDAC6 (n=25, *p<0.01), and ( H ) KDM6B (n=28, *p<0.05), but not with ( G ) KAT2A expression (n=28, p=0.0733).

    Journal: bioRxiv

    Article Title: Epigenetic Regulation of Inflammation by Dopamine in Primary Human Macrophages

    doi: 10.64898/2026.01.21.700899

    Figure Lengend Snippet: Donors from were combined with an independent archival cohort to assess correlations between dopamine receptor expression and epigenetic enzyme expression by qPCR. DRD1 expression was significantly correlated with ( A ) HDAC2 (n=28, **p<0.01), ( B ) HDAC6 (n=25, **p<0.01), ( C ) KAT2A (n=28, **p<0.01), and ( D ) KDM6B expression (n=28, ***p<0.001). DRD5 expression was significantly correlated with ( E ) HDAC2 (n=28, *p<0.01), ( F ) HDAC6 (n=25, *p<0.01), and ( H ) KDM6B (n=28, *p<0.05), but not with ( G ) KAT2A expression (n=28, p=0.0733).

    Article Snippet: TaqMan Fast Universal Master Mix, and PCR assay probes for DRD1-5 (Hs00265245_s1, Hs00241436_m1, Hs00364455_m1, Hs00609526_m1, Hs00361234_s1), IL1B (Hs01555410_m1), DNMT1 (Hs00945875_m1), DNMT3A (Hs01027166_m1), DNMT3B (Hs00171876_m1), TET2 (Hs00325999_m1), HDAC2 (Hs00231032_m1), HDAC6 (Hs00997427_m1), KDM6B (Hs00996325_g1), KAT2A (Hs00904943_gH), and 18S (4319413E) genes were purchased from Applied Biosystems.

    Techniques: Expressing

    (A) Immunoblotting analysis of the indicated HDACs in HeLa cells infected with HSV-1 (MOI = 1) for the indicated time points. (B) Immunoblotting analysis of the indicated HDACs in 3D4/21 cells infected with PRV-QXX (MOI = 1) for the indicated time points. (C and D) qRT-PCR analysis of HDAC1 and HDAC2 mRNA levels in HSV-1-infected HeLa cells (C) or PRV-QXX-infected 3D4/21 cells (D) (MOI = 1). Data are mean ± SEM; n = 3. ** P < 0.01, *** P < 0.001. (E) Immunoblotting of the indicated proteins in HeLa cells from infected with HSV-1 (MOI = 1) for the indicated time points. (F) Immunoblotting of the indicated proteins in 3D4/21 cells from infected with PRV-QXX (MOI = 1) for the indicated time points. (G) Immunoblotting analysis of the indicated proteins in liver tissues from mice mock-infected or infected with HSV-1 (1 × 10⁶ pfu per mouse) at 5 days post-infection (n = 3).

    Journal: bioRxiv

    Article Title: The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication

    doi: 10.64898/2026.01.02.697337

    Figure Lengend Snippet: (A) Immunoblotting analysis of the indicated HDACs in HeLa cells infected with HSV-1 (MOI = 1) for the indicated time points. (B) Immunoblotting analysis of the indicated HDACs in 3D4/21 cells infected with PRV-QXX (MOI = 1) for the indicated time points. (C and D) qRT-PCR analysis of HDAC1 and HDAC2 mRNA levels in HSV-1-infected HeLa cells (C) or PRV-QXX-infected 3D4/21 cells (D) (MOI = 1). Data are mean ± SEM; n = 3. ** P < 0.01, *** P < 0.001. (E) Immunoblotting of the indicated proteins in HeLa cells from infected with HSV-1 (MOI = 1) for the indicated time points. (F) Immunoblotting of the indicated proteins in 3D4/21 cells from infected with PRV-QXX (MOI = 1) for the indicated time points. (G) Immunoblotting analysis of the indicated proteins in liver tissues from mice mock-infected or infected with HSV-1 (1 × 10⁶ pfu per mouse) at 5 days post-infection (n = 3).

    Article Snippet: Antibodies against CHK1 (25887-1-AP), CHK2 (13954-1-AP), RAD51 (14961-1-AP), β-actin (66009-1-lg), P53 (10442-1-AP), HDAC1 (10197-1-AP), HDAC2 (12922-3-AP), HDAC4 (17449-1-AP), HDAC6 (12834-1-AP), HDAC11 (67949-1-Ig), and EGFP (50430-2-AP) were purchased from Proteintech; antibodies against p-P53 (9286), p-ATM (13050), ATM (2873), ATR (13934), p-ATR (2853), p-CHK1 (12302), p-CHK2 (2197), γ-H2AX (80312), H3 (4499), H4K8ac (2594), H4K12ac (13944), H4 (13919), H2AX (7631), H3K9ac (4658), H3K27ac (8173), UB (20326), and MDM2 (86934) were purchased from Cell Signaling Technology; H3K56ac antibody (07-677) was purchased from Millipore; ICP4 antibody (ab6514) was purchased from Abcam; ICP0 antibody (sc-53070) was purchased from Santa Cruz Biotechnology; FLAG antibody (F7425) was purchased from Sigma-Aldrich; HA antibody (A00169) was purchased from GenScript.

    Techniques: Western Blot, Infection, Quantitative RT-PCR

    (A) Immunoblotting analysis of the indicated proteins in HeLa cells either mock-infected or infected with HSV-1 (MOI = 1), treated with vehicle, 3-MA (10 μM), MG-132 (10 μM), or chloroquine (10 μM) for the indicated times. (B) Ubiquitination assay of HDAC1 in HeLa cells either mock-infected or infected with HSV-1 (MOI = 1) at 24 hpi. (C) Ubiquitination assay of FLAG-HDAC1 in HeLa cells transfected with HA-ubiquitin variants (WT, K48, K63), and either mock-infected or infected with HSV-1 (MOI = 1) at 24 hpi. (D) Schematic representation of HDAC1 deletion mutants. (E-I) Ubiquitination assays of FLAG-HDAC1 mutant variants in HeLa cells either mock-infected or infected with HSV-1 (MOI = 1) at 24 hpi. (J) Ubiquitination assays of FLAG-HDAC2 variants (WT and K75R) in HeLa cells either mock-infected or infected with HSV-1 (MOI = 1) at 24 hpi.

    Journal: bioRxiv

    Article Title: The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication

    doi: 10.64898/2026.01.02.697337

    Figure Lengend Snippet: (A) Immunoblotting analysis of the indicated proteins in HeLa cells either mock-infected or infected with HSV-1 (MOI = 1), treated with vehicle, 3-MA (10 μM), MG-132 (10 μM), or chloroquine (10 μM) for the indicated times. (B) Ubiquitination assay of HDAC1 in HeLa cells either mock-infected or infected with HSV-1 (MOI = 1) at 24 hpi. (C) Ubiquitination assay of FLAG-HDAC1 in HeLa cells transfected with HA-ubiquitin variants (WT, K48, K63), and either mock-infected or infected with HSV-1 (MOI = 1) at 24 hpi. (D) Schematic representation of HDAC1 deletion mutants. (E-I) Ubiquitination assays of FLAG-HDAC1 mutant variants in HeLa cells either mock-infected or infected with HSV-1 (MOI = 1) at 24 hpi. (J) Ubiquitination assays of FLAG-HDAC2 variants (WT and K75R) in HeLa cells either mock-infected or infected with HSV-1 (MOI = 1) at 24 hpi.

    Article Snippet: Antibodies against CHK1 (25887-1-AP), CHK2 (13954-1-AP), RAD51 (14961-1-AP), β-actin (66009-1-lg), P53 (10442-1-AP), HDAC1 (10197-1-AP), HDAC2 (12922-3-AP), HDAC4 (17449-1-AP), HDAC6 (12834-1-AP), HDAC11 (67949-1-Ig), and EGFP (50430-2-AP) were purchased from Proteintech; antibodies against p-P53 (9286), p-ATM (13050), ATM (2873), ATR (13934), p-ATR (2853), p-CHK1 (12302), p-CHK2 (2197), γ-H2AX (80312), H3 (4499), H4K8ac (2594), H4K12ac (13944), H4 (13919), H2AX (7631), H3K9ac (4658), H3K27ac (8173), UB (20326), and MDM2 (86934) were purchased from Cell Signaling Technology; H3K56ac antibody (07-677) was purchased from Millipore; ICP4 antibody (ab6514) was purchased from Abcam; ICP0 antibody (sc-53070) was purchased from Santa Cruz Biotechnology; FLAG antibody (F7425) was purchased from Sigma-Aldrich; HA antibody (A00169) was purchased from GenScript.

    Techniques: Western Blot, Infection, Ubiquitin Proteomics, Transfection, Mutagenesis