halicin  (Tocris)

Journal: Antibiotics

Article Title: Halicin: A New Approach to Antibacterial Therapy, a Promising Avenue for the Post-Antibiotic Era

doi: 10.3390/antibiotics14070698

Figure Lengend Snippet: MIC determination using the broth microdilution method for ( A )— S. aureus (ATCC 29213), ( B )—for E. coli (ATCC 22925), the optical density was measured at 620 nm. Values are means of three replicates and error bars indicate the standard deviation. ( C )—The photograph of a 96-well microdilution plate to determine the MIC for S. aureus (ATCC 29213), MIC = 32 µg/mL.

Article Snippet: Specifically, halicin exhibited activity against Escherichia coli ATCC ® 25922TM and Staphylococcus aureus ATCC ® 29213TM, with MICs of 16 μg/mL and 32 μg/mL, respectively.

Techniques: Standard Deviation

Journal: Antibiotics

Article Title: Halicin: A New Approach to Antibacterial Therapy, a Promising Avenue for the Post-Antibiotic Era

doi: 10.3390/antibiotics14070698

Figure Lengend Snippet: Result of SEM visualization of the effect of halicin on E. coli strain ATCC ® 25922™. ( left ): without halicin; ( right ): with halicin.

Article Snippet: Specifically, halicin exhibited activity against Escherichia coli ATCC ® 25922TM and Staphylococcus aureus ATCC ® 29213TM, with MICs of 16 μg/mL and 32 μg/mL, respectively.

Techniques:

Journal: JAC-Antimicrobial Resistance

Article Title: SAAP-148 and halicin exhibit synergistic antimicrobial activity against antimicrobial-resistant bacteria in skin but not airway epithelial culture models

doi: 10.1093/jacamr/dlaf050

Figure Lengend Snippet: Effect of SAAP-148 pretreatment, halicin treatment and combinations thereof on MRSA counts in HSE models

Article Snippet: Halicin (Tocris Bioscience, UK) was dissolved in DMSO to a concentration of 13.5 g/L and diluted in PBS to ≤54 mg/L.

Techniques:

Journal: JAC-Antimicrobial Resistance

Article Title: SAAP-148 and halicin exhibit synergistic antimicrobial activity against antimicrobial-resistant bacteria in skin but not airway epithelial culture models

doi: 10.1093/jacamr/dlaf050

Figure Lengend Snippet: Effect of SAAP-148 pretreatment, halicin treatment and combinations thereof on MRSA counts in PBEC models

Article Snippet: Halicin (Tocris Bioscience, UK) was dissolved in DMSO to a concentration of 13.5 g/L and diluted in PBS to ≤54 mg/L.

Techniques:

Journal: Antibiotics

Article Title: Halicin: A New Horizon in Antibacterial Therapy against Veterinary Pathogens

doi: 10.3390/antibiotics13060492

Figure Lengend Snippet: Determination of minimum inhibitory concentration and minimum bactericidal concentration of SU3327 and commonly used antimicrobial agents against the test pathogens (20 strains each, totaling 260 strains).

Article Snippet: The time-killing curve results illustrated a concentration-dependent bactericidal effect of halicin against E. coli ATCC 25922, S. aureus ATCC 29213, and APP S6 ( ).

Techniques: Concentration Assay, Bacteria

Journal: Antibiotics

Article Title: Halicin: A New Horizon in Antibacterial Therapy against Veterinary Pathogens

doi: 10.3390/antibiotics13060492

Figure Lengend Snippet: Antimicrobial kinetic curves of halicin against E. coli ATCC 25922 ( A ), S. aureus ATCC 29213 ( B ), and APP S6 ( C ).

Article Snippet: The time-killing curve results illustrated a concentration-dependent bactericidal effect of halicin against E. coli ATCC 25922, S. aureus ATCC 29213, and APP S6 ( ).

Techniques:

Journal: Antibiotics

Article Title: Halicin: A New Horizon in Antibacterial Therapy against Veterinary Pathogens

doi: 10.3390/antibiotics13060492

Figure Lengend Snippet: The post-antibiotic effects and post-antibiotic sub-minimum inhibitory concentration effects against E. coli ATCC 25922 ( A ), S. aureus ATCC 29213 ( B ), and APP S6 (C) for halicin.

Article Snippet: The time-killing curve results illustrated a concentration-dependent bactericidal effect of halicin against E. coli ATCC 25922, S. aureus ATCC 29213, and APP S6 ( ).

Techniques: Concentration Assay

Journal: Antibiotics

Article Title: Halicin: A New Horizon in Antibacterial Therapy against Veterinary Pathogens

doi: 10.3390/antibiotics13060492

Figure Lengend Snippet: Comparison of the post-antibiotic effects and post-antibiotic sub-minimum inhibitory concentration effects of antibacterial drugs against E. coli ATCC 25922, S. aureus ATCC 29213, and APP S6.

Article Snippet: The time-killing curve results illustrated a concentration-dependent bactericidal effect of halicin against E. coli ATCC 25922, S. aureus ATCC 29213, and APP S6 ( ).

Techniques: Comparison, Concentration Assay

Journal: Antibiotics

Article Title: Halicin: A New Horizon in Antibacterial Therapy against Veterinary Pathogens

doi: 10.3390/antibiotics13060492

Figure Lengend Snippet: Evolution of resistance to halicin and control drugs in E. coli ATCC 25922 ( A ), S. aureus ATCC 29213 ( B ), and APP S6 ( C ) after 40 d of passaging.

Article Snippet: The time-killing curve results illustrated a concentration-dependent bactericidal effect of halicin against E. coli ATCC 25922, S. aureus ATCC 29213, and APP S6 ( ).

Techniques: Control, Passaging

Journal: Antibiotics

Article Title: Halicin: A New Horizon in Antibacterial Therapy against Veterinary Pathogens

doi: 10.3390/antibiotics13060492

Figure Lengend Snippet: The minimum preventable concentrations and mutant selection windows for halicin and control drugs against E. coli ATCC 25922, S. aureus ATCC 29213, and APP S6.

Article Snippet: The time-killing curve results illustrated a concentration-dependent bactericidal effect of halicin against E. coli ATCC 25922, S. aureus ATCC 29213, and APP S6 ( ).

Techniques: Mutagenesis, Selection, Control