bacillus subtilis  (ATCC)

Journal: Frontiers in Neurology

Article Title: Correlation between electrode location and clinical efficacy of deep brain stimulation of the globus pallidus internus in isolated generalized dystonia

doi: 10.3389/fneur.2026.1779301

Figure Lengend Snippet: Predictors of motor outcomes after GPi-DBS. A simple linear regression model was constructed to assess candidate predictive factors for movement outcomes, including baseline variables (demographic and clinical). Significant negative correlations were observed between motor outcome and preoperative HAMA (E) , preoperative HAMD (F) , while Disease duration (A) , Age at surgery (B) , Age of onset (C) , Preoperative BFMDRS-M total score (D) , MMSE score ( G) and MOCAscore (H) showed no significant correlations.

Article Snippet: This study included patients with IGD who underwent bilateral GPi-DBS treatment in the Department of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, from January 2016 to December 2021, and had complete follow-up data.

Techniques: Construct

Journal: Frontiers in Neurology

Article Title: Correlation between electrode location and clinical efficacy of deep brain stimulation of the globus pallidus internus in isolated generalized dystonia

doi: 10.3389/fneur.2026.1779301

Figure Lengend Snippet: Predictors of motor outcomes after GPi-DBS. A simple linear regression model was constructed to assess candidate predictive factors for movement outcomes, including baseline variables (demographic and clinical). Significant negative correlations were observed between motor outcome and preoperative HAMA (E) , preoperative HAMD (F) , while Disease duration (A) , Age at surgery (B) , Age of onset (C) , Preoperative BFMDRS-M total score (D) , MMSE score ( G) and MOCAscore (H) showed no significant correlations.

Article Snippet: A total of 17 IGD patients who received bilateral GPi-DBS at Beijing Tiantan Hospital from January 2016 to December 2021 and had complete follow-up data were enrolled.

Techniques: Construct

Journal: npj Imaging

Article Title: Bridging preclinical and clinical fluorescence-guided surgery with advanced cancer vision goggles

doi: 10.1038/s44303-026-00170-x

Figure Lengend Snippet: Small animal fluorescence imaging systems ( a ) Pearl and ( b ) IVIS SpectrumCT equipped with enclosed, light-tight imaging chambers to minimize ambient light. c Advanced CVG platform for preclinical and clinical NIR cancer imaging. Cart-based clinical FGS systems ( d ) Quest Spectrum and ( e ) Stryker SPY-PHI equipped with a handheld camera/light tethered by power and network cords.

Article Snippet: The human tumor tissue selected for this analysis consisted of samples with saturated intensity pixels not exceeding 15%, which exhibited similar imaging characteristics between the CVG and Stryker SPY-PHI systems.

Techniques: Fluorescence, Imaging

Journal: npj Imaging

Article Title: Bridging preclinical and clinical fluorescence-guided surgery with advanced cancer vision goggles

doi: 10.1038/s44303-026-00170-x

Figure Lengend Snippet: a Representative visible-light image captured by CVG. b Pseudocolored NIR fluorescence overlay generated using a dynamic thresholding algorithm, overlaid on the visible image. The three boxed values represent fluorescence intensity thresholds for the top 10%, top 5%, and maximum intensity pixels. CVG images were acquired at a resolution of 480 × 640 (height × width) pixels from a fixed 50 cm working distance. c Visible image of the same tissue captured by the handheld Stryker SPY-PHI system (SPY-PHI). d NIR fluorescence (blue-to-red pseudocolor) overlaid on grayscale white-light image obtained by the Stryker SPY-PHI system in SPY-CSF mode. e Raw NIR fluorescence image from CVG. f , NIR fluorescence image obtained by the Stryker SPY-PHI system in SPY contrast mode. g Overlay of the top 15% fluorescence intensity pixels from the CVG NIR image (red) and the transformed Stryker SPY-PHI NIR image (green) in an RGB composite; yellow indicates overlapping regions. h Dice coefficient comparing the top 15% pixels from both systems: 0.84 ± 0.04 ( n = 6), with two outliers shown as brown dots (0.50 and 0.59). i Normalized intensity map (NIM) derived from the CVG NIR grayscale image, showing a mean of 19.84 ± 14.23 and a maximum of 54.93. j NIM from the transformed SPY-PHI image, with a mean of 2.76 ± 1.28 and a maximum of 4.77. Both NIMs were normalized by the mean intensity of the lowest 10% of pixels in the tissue sample. k Overlay of high-intensity NIM regions (NIM > 1.5) from CVG (red) and Stryker SPY-PHI (green) in RGB format, where yellow indicates overlap. l , Dice coefficient for NIM > 1.5 comparison: 0.91 ± 0.02 ( n = 6). Scale bars, 5 mm.

Article Snippet: The human tumor tissue selected for this analysis consisted of samples with saturated intensity pixels not exceeding 15%, which exhibited similar imaging characteristics between the CVG and Stryker SPY-PHI systems.

Techniques: Fluorescence, Generated, Transformation Assay, Derivative Assay, Comparison

Journal: npj Imaging

Article Title: Bridging preclinical and clinical fluorescence-guided surgery with advanced cancer vision goggles

doi: 10.1038/s44303-026-00170-x

Figure Lengend Snippet: Small animal fluorescence imaging systems ( a ) Pearl and ( b ) IVIS SpectrumCT equipped with enclosed, light-tight imaging chambers to minimize ambient light. c Advanced CVG platform for preclinical and clinical NIR cancer imaging. Cart-based clinical FGS systems ( d ) Quest Spectrum and ( e ) Stryker SPY-PHI equipped with a handheld camera/light tethered by power and network cords.

Article Snippet: Dice coefficient analysis revealed high correlation between CVG and Stryker SPY-PHI fluorescence localization for both the top 15% of fluorescence pixels (0.84 ± 0.04) and for pixels with NIM > 1.5 (0.91 ± 0.02) (Fig. ).

Techniques: Fluorescence, Imaging

Journal: npj Imaging

Article Title: Bridging preclinical and clinical fluorescence-guided surgery with advanced cancer vision goggles

doi: 10.1038/s44303-026-00170-x

Figure Lengend Snippet: a Representative visible-light image captured by CVG. b Pseudocolored NIR fluorescence overlay generated using a dynamic thresholding algorithm, overlaid on the visible image. The three boxed values represent fluorescence intensity thresholds for the top 10%, top 5%, and maximum intensity pixels. CVG images were acquired at a resolution of 480 × 640 (height × width) pixels from a fixed 50 cm working distance. c Visible image of the same tissue captured by the handheld Stryker SPY-PHI system (SPY-PHI). d NIR fluorescence (blue-to-red pseudocolor) overlaid on grayscale white-light image obtained by the Stryker SPY-PHI system in SPY-CSF mode. e Raw NIR fluorescence image from CVG. f , NIR fluorescence image obtained by the Stryker SPY-PHI system in SPY contrast mode. g Overlay of the top 15% fluorescence intensity pixels from the CVG NIR image (red) and the transformed Stryker SPY-PHI NIR image (green) in an RGB composite; yellow indicates overlapping regions. h Dice coefficient comparing the top 15% pixels from both systems: 0.84 ± 0.04 ( n = 6), with two outliers shown as brown dots (0.50 and 0.59). i Normalized intensity map (NIM) derived from the CVG NIR grayscale image, showing a mean of 19.84 ± 14.23 and a maximum of 54.93. j NIM from the transformed SPY-PHI image, with a mean of 2.76 ± 1.28 and a maximum of 4.77. Both NIMs were normalized by the mean intensity of the lowest 10% of pixels in the tissue sample. k Overlay of high-intensity NIM regions (NIM > 1.5) from CVG (red) and Stryker SPY-PHI (green) in RGB format, where yellow indicates overlap. l , Dice coefficient for NIM > 1.5 comparison: 0.91 ± 0.02 ( n = 6). Scale bars, 5 mm.

Article Snippet: Dice coefficient analysis revealed high correlation between CVG and Stryker SPY-PHI fluorescence localization for both the top 15% of fluorescence pixels (0.84 ± 0.04) and for pixels with NIM > 1.5 (0.91 ± 0.02) (Fig. ).

Techniques: Fluorescence, Generated, Transformation Assay, Derivative Assay, Comparison