fty720 (MedChemExpress)
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Structured Review
MedChemExpress
fty720
Fty720, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 87 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fty720/Fingolimod+hydrochloride/pmc12996997-359-0-11
Average 97 stars, based on 87 article reviews
Fty720, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 87 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fty720/Fingolimod+hydrochloride/pmc12996997-359-0-11
Average 97 stars, based on 87 article reviews
fty720 - by Bioz Stars,
2026-09
97/100 stars
Images
1) Product Images from "Chronic inflammation-responsive hydrogel restores myeloid-T cell crosstalk to reinvigorate antitumor immunity against metastatic colorectal cancer"
Article Title: Chronic inflammation-responsive hydrogel restores myeloid-T cell crosstalk to reinvigorate antitumor immunity against metastatic colorectal cancer
Journal: Bioactive Materials
doi: 10.1016/j.bioactmat.2026.03.012
Figure Legend Snippet: TRANS enhances tumoral T cell abundance and synergizes with immune checkpoint inhib itors. (A) UMAP visualization of lymphocytes in the TME following PBS or TRANS treatment. (B) UMAP visualization of lymphocyte clusters. (C) Proportional distribution of lymphocyte clusters. (D) Expression of cluster-specific marker genes. (E) Top 10 maker genes in CD8 + effector T cells (Teff). (F) Volcano plot of differentially expressed genes in CD8 + Teff between TRANS and PBS. (G) Dot plot showing upregulated pathways in IFN-γ + T cells (TRANS vs PBS), with dot size reflecting KEGG enrichment intensity. (H) Dot plot of ligand-receptor interactions between myeloid cells and T cells (TRANS vs PBS). Ligands (blue) and receptors (red) are labeled. (I) Experimental design of tumor therapy by TRANS combination with FTY720. (J) Tumor growth curve in mice treated with PBS, TRANS, and FTY720+TRANS; n = 5. (K – M) Tumor-infiltrating CD4 + and CD8 + T cells (K), Granzyme + CD8 + T or IFN-γ + CD8 + T cells counts (L), and Exhausted T cells (M) in TME; n = 5. (N) Scheme of tumor therapy by TRANS combined with immune checkpoint inhibitors (ICI). (O and P) Individual tumor changes (O) and Survival rate (Q) of tumor-bearing mice with different treatments; n = 5. (Q and R) Ex vivo IFN-γ expression (Q) and Quantification (R) in splenic CD8 + T cells with PMA/ionomycin stimulation; n = 3. (S) IFN-γ secretion by splenic T cells following αCD3/αCD28 stimulation; n = 3. Data are presented as mean ± SD, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. Significance was calculated using One-way ANOVA.
Techniques Used: Inhibition, Expressing, Marker, Labeling, Ex Vivo
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