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dss plus epptb  (MedChemExpress)


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    MedChemExpress dss plus epptb
    Fecal Tryp, PEA, and Tyr in UC and <t>DSS-colitis</t> mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with <t>EPPTB</t> (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.
    Dss Plus Epptb, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dss plus epptb/product/MedChemExpress
    Average 94 stars, based on 2 article reviews
    dss plus epptb - by Bioz Stars, 2026-02
    94/100 stars

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    1) Product Images from "The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition"

    Article Title: The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition

    Journal: Biochemistry and Biophysics Reports

    doi: 10.1016/j.bbrep.2025.102432

    Fecal Tryp, PEA, and Tyr in UC and DSS-colitis mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with EPPTB (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.
    Figure Legend Snippet: Fecal Tryp, PEA, and Tyr in UC and DSS-colitis mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with EPPTB (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.

    Techniques Used: Inhibition, Ex Vivo, Control



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    Image Search Results


    Fecal Tryp, PEA, and Tyr in UC and DSS-colitis mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with EPPTB (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.

    Journal: Biochemistry and Biophysics Reports

    Article Title: The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition

    doi: 10.1016/j.bbrep.2025.102432

    Figure Lengend Snippet: Fecal Tryp, PEA, and Tyr in UC and DSS-colitis mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with EPPTB (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.

    Article Snippet: Following one cycle of DSS administration, all mice developed consistent colitis and were randomly allocated into two groups (n = 6 per group): DSS alone, and DSS plus EPPTB (10 mg/kg; MedChemExpress, New Jersey, USA).

    Techniques: Inhibition, Ex Vivo, Control