Journal: The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Article Title: Role of TGF-β1/SMADs signalling pathway in resveratrol-induced reduction of extracellular matrix deposition by dexamethasone-treated human trabecular meshwork cells
doi: 10.4196/kjpp.2024.28.4.345
Figure Lengend Snippet: Effect of TR on the (A) COLIA1 gene (B) COLIA2 gene (C) COLI protein (D) COLIIIA1 gene (E) COLIII protein (F) COLIVA1 gene (G) COLIVA2 gene (H) COLIV protein (I) FN1 gene (J) Fibronectin protein (K) ACTA2 gene and (L) Alpha smooth muscle actin protein expressions by the DEXA-treated HTMCs after treatment for three and seven days. Bars represent mean ± SD (n = 3). *p < 0.05, ANOVA with Tukey’s post-hoc. TR, resveratrol; ECM, extracellular matrix; DEXA, dexamethasone; HTMC, human trabecular meshwork cell; DMEM, Dulbecco’s modified Eagle medium; DMSO, dimethyl sulfoxide.
Article Snippet: These proteins included COLI, total and active TGF-β1, SMAD4, SMAD7, PAI-1 and tPA (Finetest), COLIII, COLIV, FN (Elabscience Biotechnology Co.) and α-SMA (BioAssay Technology Laboratory).
Techniques: Modification