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lxr bs 10311r bioss  (Bioss)


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    Bioss lxr bs 10311r bioss
    Lxr Bs 10311r Bioss, supplied by Bioss, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lxr bs 10311r bioss/product/Bioss
    Average 94 stars, based on 2 article reviews
    lxr bs 10311r bioss - by Bioz Stars, 2026-02
    94/100 stars

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    rabbit anti lxrα  (Bioss)
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    DNLA suppresses <t>LXRα</t> and IDOL protein expression in HepG2 cells. (A) Protein expression of LXRα and IDOL in HepG2 cells was assessed by western blotting. Normalized intensity of (B) LXRα and (C) IDOL vs. GAPDH, presented as the mean ± SD of three independent experiments. * P<0.05, ** P<0.01 and **** P<0.0001. DNLA, Dendrobium nobile Lindl. alkaloids; LPS, lipopolysaccharides; LXRα, liver X receptor α; IDOL, inducible degrader of the low-density lipoprotein receptor.
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    DNLA suppresses LXRα and IDOL protein expression in HepG2 cells. (A) Protein expression of LXRα and IDOL in HepG2 cells was assessed by western blotting. Normalized intensity of (B) LXRα and (C) IDOL vs. GAPDH, presented as the mean ± SD of three independent experiments. * P<0.05, ** P<0.01 and **** P<0.0001. DNLA, Dendrobium nobile Lindl. alkaloids; LPS, lipopolysaccharides; LXRα, liver X receptor α; IDOL, inducible degrader of the low-density lipoprotein receptor.

    Journal: Experimental and Therapeutic Medicine

    Article Title: Dendrobium nobile Lindl. alkaloids improve lipid metabolism by increasing LDL uptake through regulation of the LXRα/IDOL/LDLR pathway and inhibition of PCSK9 expression in HepG2 cells

    doi: 10.3892/etm.2025.12796

    Figure Lengend Snippet: DNLA suppresses LXRα and IDOL protein expression in HepG2 cells. (A) Protein expression of LXRα and IDOL in HepG2 cells was assessed by western blotting. Normalized intensity of (B) LXRα and (C) IDOL vs. GAPDH, presented as the mean ± SD of three independent experiments. * P<0.05, ** P<0.01 and **** P<0.0001. DNLA, Dendrobium nobile Lindl. alkaloids; LPS, lipopolysaccharides; LXRα, liver X receptor α; IDOL, inducible degrader of the low-density lipoprotein receptor.

    Article Snippet: Subsequently, the membranes were blocked with 5% skimmed dry milk in Tris-buffer solution with 0.1% Tween-20 (TBST) at room temperature for 2 h before being incubated overnight at 4˚C with the following primary antibodies (1:1,000): Rabbit anti-LDLR (cat. no. ab30532; Abcam), rabbit anti-PCSK9 (cat. no. ab185194; Abcam), rabbit anti-IDOL (cat. no. bs-9674R; BIOSS), rabbit anti-SREBP2 (cat. no. ab30682; Abcam), rabbit anti-LXRα (cat. no. bs-10311R; BIOSS), rabbit anti-HNF1α (cat. no. 89670S; Cell Signaling Technology, Inc.), rabbit anti-3-hydroxy-3-methyl glutaryl-coenzyme A reductase (HMGCR; cat. no. ab242315; Abcam), rabbit anti-cytochrome P450 (CYP) 7A1 (cat. no. bs-21430R; BIOSS) and mouse anti-GAPDH (cat. no. 97166S; Cell Signaling Technology, Inc.).

    Techniques: Expressing, Western Blot

    T0901317, an LXRα agonist, reverses the decrease in IDOL and LXRα expression induced by DNLA and reduces the LDLR content in HepG2 cells. (A) Protein expression of LXRα, IDOL and LDLR in HepG2 cells assessed by western blotting. Normalized intensity of (B) LXRα, (C) IDOL and (D) LDLR vs. GAPDH, presented as the mean ± SD of three independent experiments. * P<0.05, ** P<0.01, *** P<0.001 and **** P<0.0001. DNLA, Dendrobium nobile Lindl. alkaloids; LPS, lipopolysaccharides; LXRα, liver X receptor α; IDOL, inducible degrader of the low-density lipoprotein receptor; LDLR, low-density lipoprotein receptor.

    Journal: Experimental and Therapeutic Medicine

    Article Title: Dendrobium nobile Lindl. alkaloids improve lipid metabolism by increasing LDL uptake through regulation of the LXRα/IDOL/LDLR pathway and inhibition of PCSK9 expression in HepG2 cells

    doi: 10.3892/etm.2025.12796

    Figure Lengend Snippet: T0901317, an LXRα agonist, reverses the decrease in IDOL and LXRα expression induced by DNLA and reduces the LDLR content in HepG2 cells. (A) Protein expression of LXRα, IDOL and LDLR in HepG2 cells assessed by western blotting. Normalized intensity of (B) LXRα, (C) IDOL and (D) LDLR vs. GAPDH, presented as the mean ± SD of three independent experiments. * P<0.05, ** P<0.01, *** P<0.001 and **** P<0.0001. DNLA, Dendrobium nobile Lindl. alkaloids; LPS, lipopolysaccharides; LXRα, liver X receptor α; IDOL, inducible degrader of the low-density lipoprotein receptor; LDLR, low-density lipoprotein receptor.

    Article Snippet: Subsequently, the membranes were blocked with 5% skimmed dry milk in Tris-buffer solution with 0.1% Tween-20 (TBST) at room temperature for 2 h before being incubated overnight at 4˚C with the following primary antibodies (1:1,000): Rabbit anti-LDLR (cat. no. ab30532; Abcam), rabbit anti-PCSK9 (cat. no. ab185194; Abcam), rabbit anti-IDOL (cat. no. bs-9674R; BIOSS), rabbit anti-SREBP2 (cat. no. ab30682; Abcam), rabbit anti-LXRα (cat. no. bs-10311R; BIOSS), rabbit anti-HNF1α (cat. no. 89670S; Cell Signaling Technology, Inc.), rabbit anti-3-hydroxy-3-methyl glutaryl-coenzyme A reductase (HMGCR; cat. no. ab242315; Abcam), rabbit anti-cytochrome P450 (CYP) 7A1 (cat. no. bs-21430R; BIOSS) and mouse anti-GAPDH (cat. no. 97166S; Cell Signaling Technology, Inc.).

    Techniques: Expressing, Western Blot