aom (MedChemExpress)
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MedChemExpress
aom
Aom, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 20 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/aom/Azoxymethane/pmc13134328-259-12-16
Average 94 stars, based on 20 article reviews
Aom, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 20 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/aom/Azoxymethane/pmc13134328-259-12-16
Average 94 stars, based on 20 article reviews
aom - by Bioz Stars,
2026-09
94/100 stars
Images
1) Product Images from "Atorvastatin promotes lipid catabolism in colorectal cancer via FDFT1‒mediated inhibition of the PI3K/AKT pathway"
Article Title: Atorvastatin promotes lipid catabolism in colorectal cancer via FDFT1‒mediated inhibition of the PI3K/AKT pathway
Journal: Cell Communication and Signaling : CCS
doi: 10.1186/s12964-026-02802-6
Figure Legend Snippet: ATST introduces ferroptosis‒like cell death in CRC A Protein expression levels of NRF2 and GPX4 B The expression of NRF2 in the cytoplasm and nucleus C mRNA expression level of NRF2, SLC7A11 and GPX4 D Changes in intracellular Fe 2+ content E Changes in intracellular GSH content F Changes in intracellular MDA content G TEM of colon tumours in AOM/DSS‒induced colon cancer mice. Scar bar :500 nm
Techniques Used: Expressing
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Injection:Article Title: The combination of Clostridium butyricum and Akkermansia muciniphila mitigates DSS-induced colitis and attenuates colitis-associated tumorigenesis by modulating gut microbiota and reducing CD8 + T cells in mice Article Snippet: .. After acclimation for 1 week, mice weighing (20 ± 2) g were selected for AOM/DSS-induced colon cancer modeling, the molding process is outlined follows. (i) Every 3 days, the experimental groups were administered 100 μL of bacterial-suspension solution (Combo group: mice were given 50 μL CB [OD = 1.2, 3.0 × 10 8 CFU/mL] and 50 μl AKK [OD 600 = 1.6, 3.0 × 109 CFU/mL]) by gavage, and the Combo + aPD-L1 group received six intraperitoneal injections of Anti-PD-L1 mAb (aPD-L1, RecombiMAb anti-mouse PD-L1 [B7-H1] [LALA-PG, MedImmune, RRID: AB_10949073, Cat# BE0101-50mg]) at different time points, while the other groups received six intraperitoneal injections of NS at the same time points. (ii) On day 1, the mice were weighed and noted, and Article Title: Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice. Article Snippet: Next, pseudo-germ-free CRC mice were modeled in this study using the following method: 0.2 g/L of ampicillin (A8180, Solarbio, Beijing, China), neomycin (N8090, Solarbio), metronidazole (M8060, Solarbio) and 0.1 g/L of vancomycin (S17059, Yuanye Bio, Shanghai, China) were added to the drinking water daily for a total of two weeks. .. Following the last dose of antibiotics, mice were subjected to an intraperitoneal injection of one dose of 10 mg/kg of Article Title: Atorvastatin promotes lipid catabolism in colorectal cancer via FDFT1‒mediated inhibition of the PI3K/AKT pathway Article Snippet: .. The MODEL and ATST groups of mice received an intraperitoneal injection of Article Title: Potential Benefits of Metformin Via Roseburia Intestinalis in High-fat Diet-fed Mice With Colorectal Adenomas. Article Snippet: It might also have an important role in the gastrointestinal tract, the gut microbial communities, and the tissue-resident immune cells [4, 5].. For instance, Met suppresses colonic tumorigenicity in APCMin/+ mice by modulation of the gut microbiota [6].. However, whether Met has the potential to halt the development of CRA and the mechanism involving gut microbiota awaits further exploration. Article Title: Escherichia coli promotes colorectal cancer metastasis by maintaining enhancer-promoter loops through releasing neutrophil extracellular traps Article Snippet: 3 d after the injection of MC38 cells or patient organoids, Anti-CD3 Antibody (OKT-3) (3 mg/kg, HY-P990864, MedChemExpress, NJ, USA), Anumigilimab (2 mg/kg, HY-P99440, MedChemExpress), Ca 2+ channel agonist 1 (4 mg/kg, HY-41076, MedChemExpress), Clodronate Liposomes (40337ES08, Yeasen, China), DMSO (HY-Y0320C, MedChemExpress), DNase I (10 mg/kg, 10104159001, Merck), GSK484 hydrochloride (4 mg/kg, HY-100514, MedChemExpress), GSK583 (4 mg/kg, HY-100339, MedChemExpress), InVivoMAb anti-mouse CD3ε (5 mg/kg, catalog number: BE0001-1, clone name: 145-2C11, Bio X Cell, PA, USA), InVivoMAb anti-mouse Ly6G (5 mg/kg, catalog number: BE0075, clone name: RB6-8C5, Bio X Cell), InVivoMAb rat IgG2a isotype control (5 mg/kg, catalog number: BE0251, clone name: RG7/1.30, Bio X Cell), JNK-IN-8 (3 mg/kg, HY-13319, MedChemExpress), JSH-23 (5 mg/kg, HY-13982, MedChemExpress), MLKL-IN-1 (5 mg/kg, HY-139878, MedChemExpress), NOD1/2 antagonist-1 (5 mg/kg, HY-146034, MedChemExpress), Paquinimod (5 mg/kg, HY-100442, MedChemExpress), PMA (5 mg/kg, P8139, Merck), p38 MAPK-IN-1 (5 mg/kg, HY-12839, MedChemExpress), SCH772984 (3 mg/kg, HY-50846, MedChemExpress), Sparstolonin B (5 mg/kg, HY-116213, MedChemExpress), or Stattic (5 mg/kg, HY-13818, MedChemExpress) were injected into the tail vein of mice once every three days for a total of five times. .. 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(i) Every 3 days, the experimental groups were administered 100 μL of bacterial-suspension solution (Combo group: mice were given 50 μL CB [OD = 1.2, 3.0 × 108 CFU/mL] and 50 μl AKK [OD600 = 1.6, 3.0 × 109 CFU/mL]) by gavage, and the Combo + aPD-L1 group received six intraperitoneal injections of Anti-PD-L1 mAb (aPD-L1, RecombiMAb anti-mouse PD-L1 [B7-H1] [LALA-PG, MedImmune, RRID: AB_10949073, Cat# BE0101-50mg]) at different time points, while the other groups received six intraperitoneal injections of NS at the same time points. (ii) On day 1, the mice were weighed and noted, and other:Article Title: Escherichia coli promotes colorectal cancer metastasis by maintaining enhancer-promoter loops through releasing neutrophil extracellular traps. Article Snippet: 3 d after the injection of MC38 cells or patient organoids, Anti-CD3 Antibody (OKT-3) (3 mg/kg, HY-P990864, MedChemExpress, NJ, USA), Anumigilimab (2 mg/kg, HY-P99440, MedChemExpress), Ca2+ channel agonist 1 (4 mg/kg, HY-41076, MedChemExpress), Clodronate Liposomes (40337ES08, Yeasen, China), DMSO (HY-Y0320C, MedChemExpress), DNase I (10 mg/kg, 10104159001, Merck), GSK484 hydrochloride (4 mg/kg, HY-100514, MedChemExpress), GSK583 (4 mg/kg, HY-100339, MedChemExpress), InVivoMAb anti-mouse CD3ε (5 mg/kg, catalog number: BE0001-1, clone name: 145-2C11, Bio X Cell, PA, USA), InVivoMAb anti-mouse Ly6G (5 mg/kg, catalog number: BE0075, clone name: RB6-8C5, Bio X Cell), InVivoMAb rat IgG2a isotype control (5 mg/kg, catalog number: BE0251, clone name: RG7/1.30, Bio X Cell), JNK-IN-8 (3 mg/kg, HY-13319, MedChemExpress), JSH23 (5 mg/kg, HY-13982, MedChemExpress), MLKL-IN-1 (5 mg/kg, HY-139878, MedChemExpress), NOD1/2 antagonist-1 (5 mg/kg, HY-146034, MedChemExpress), Paquinimod (5 mg/kg, HY-100442, MedChemExpress), PMA (5 mg/kg, P8139, Merck), |