aars1 (MedChemExpress)
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MedChemExpress
aars1
Aars1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/aars1/Alanyl-tRNA+synthetase%2C+Human/pm41713664-282-44-54
Average 93 stars, based on 2 article reviews
Aars1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/aars1/Alanyl-tRNA+synthetase%2C+Human/pm41713664-282-44-54
Average 93 stars, based on 2 article reviews
aars1 - by Bioz Stars,
2026-10
93/100 stars
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Related Articles
In Vitro:Article Title: Targeting AARS1-dependent lactylation improves neuronal process plasticity and mitigates cognitive deficits in sepsis-associated encephalopathy. Article Snippet: Sepsis-associated encephalopathy (SAE) is a frequent and severe neurological complication of systemic infection, strongly associated with long-term cognitive impairment.1 Despite its clinical significance, no targeted therapies are currently available.. In this study, we established a murine model of sepsis using cecal ligation and puncture (CLP) and identified a metabolic pathway in which lactate accumulation drives neuronal process injury through aberrant activation of the ATRIP–ATR signaling axis.. During sepsis, AARS1—the primary lactyltransferase responsible for lactylation in neuronal processes—catalyzes the lactylation of ATRIP at lysine 127 (K127), triggering ATRIP–ATR complex formation and pathway activation independent of DNA damage. |