aars1 Search Results


mirna 3´utr target expression clone for human aars1  (Genecopoeia)
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GeneCopoeia offers genome-wide human, mouse and rat microRNA (miRNA) 3′ UTR target clones in mammalian expression vectors. miRNA 3′ UTR target clones can be used for miRNA target identification and functional validation of predicted targets,
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aars1, mouse  (MedChemExpress)
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The AARS1 protein facilitates the two-step process of attaching alanine to tRNA(Ala): first, alanine is activated by ATP to form Ala-AMP, and then it is transferred to the acceptor end of tRNA(Ala). AARS1 also corrects
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aars1 induced lactylation  (MedChemExpress)
93
MedChemExpress aars1 induced lactylation
A Immunofluorescence assay results indicated that AARS1 overexpression promoted STAT1 nuclear translocation in HGECs and HK-2 cells. However, AARS1 5M did not have these effects (scale bar: 100 μm). B Western blotting assays indicated that AARS1 overexpression increased STAT1 phosphorylation in HGECs and HK-2 cells. However, AARS1 5M did not have these effects. C ChIP‒qPCR revealed that AARS1 overexpression enhanced the binding of STAT1 to the ELOVL5 promoter region in HGECs and HK-2 cells. However, AARS1 5M did not have these effects. D AARS1 lactylated STAT1 with lactate in vitro. E Co-IP assays indicated that <t>AARS1</t> <t>induced</t> STAT1 lactylation in HGECs and HK-2 cells. Moreover, AARS1 overexpression increased STAT1, H3K18la and ELOVL5 levels in HGECs and HK-2 cells. However, AARS1 5M did not have these effects. (*P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001).
Aars1 Induced Lactylation, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/aars1/Alanyl-tRNA+synthetase%2C+Human/pmc13036035-326-16-3
Average 93 stars, based on 1 article reviews
aars1 induced lactylation - by Bioz Stars, 2026-10
93/100 stars
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orf expression clone for aars1  (Genecopoeia)
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GeneCopoeia offers the largest collection of ORF cDNA clones, with genome-wide coverage for human and mouse. All ORF cDNAs can be readily expressed in combination with a variety of fusion tags (fluorescence, antibody, solubility, purification
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alars antibody / alanyl-trna synthetase / aars1  (NSJ Bioreagents)
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An aminoacyl-tRNA synthetase (AlaRS, aaRS or ARS), also called tRNA-ligase, is an enzyme that attaches the appropriate amino acid onto its corresponding tRNA. The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases,
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anti-alars/aars1 antibody picoband  (Boster Bio)
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Boster Bio Anti-AlaRS/AARS1 Antibody Picoband® catalog # A03935-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality,
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sgrna/cas9 all-in-one expression clones targeting aars1  (Genecopoeia)
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Transfect cells with our CRISPR plasmids with Cas9 and sgRNA for human, mouse, and rat. Search our database of more than 45,000 human, mouse, and rat genes for genome editing using CRISPR. sgRNA expression plasmids
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shrna clone set against human aars1  (Genecopoeia)
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OmicsLink™ shRNA clone collections include lentiviral and non-viral vector-based shRNA constructs against genome-wide human, mouse and rat genes. shRNA of varying lengths (19 to 29 bases) were designed using a proprietary algorithm to make shRNA
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promoter reporter clone for human aars1  (Genecopoeia)
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Using a secreted and robust Gaussia Luciferase (GLuc) as the reporter, GeneCopoeia GLuc-ON™ promoter clones are designed for promoter analysis by detecting the real-time activities of about 39,500 human, 28,700 mouse and 17,500 rat promoters
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Image Search Results


A Immunofluorescence assay results indicated that AARS1 overexpression promoted STAT1 nuclear translocation in HGECs and HK-2 cells. However, AARS1 5M did not have these effects (scale bar: 100 μm). B Western blotting assays indicated that AARS1 overexpression increased STAT1 phosphorylation in HGECs and HK-2 cells. However, AARS1 5M did not have these effects. C ChIP‒qPCR revealed that AARS1 overexpression enhanced the binding of STAT1 to the ELOVL5 promoter region in HGECs and HK-2 cells. However, AARS1 5M did not have these effects. D AARS1 lactylated STAT1 with lactate in vitro. E Co-IP assays indicated that AARS1 induced STAT1 lactylation in HGECs and HK-2 cells. Moreover, AARS1 overexpression increased STAT1, H3K18la and ELOVL5 levels in HGECs and HK-2 cells. However, AARS1 5M did not have these effects. (*P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001).

Journal: Cell Death and Differentiation

Article Title: AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy

doi: 10.1038/s41418-025-01587-4

Figure Lengend Snippet: A Immunofluorescence assay results indicated that AARS1 overexpression promoted STAT1 nuclear translocation in HGECs and HK-2 cells. However, AARS1 5M did not have these effects (scale bar: 100 μm). B Western blotting assays indicated that AARS1 overexpression increased STAT1 phosphorylation in HGECs and HK-2 cells. However, AARS1 5M did not have these effects. C ChIP‒qPCR revealed that AARS1 overexpression enhanced the binding of STAT1 to the ELOVL5 promoter region in HGECs and HK-2 cells. However, AARS1 5M did not have these effects. D AARS1 lactylated STAT1 with lactate in vitro. E Co-IP assays indicated that AARS1 induced STAT1 lactylation in HGECs and HK-2 cells. Moreover, AARS1 overexpression increased STAT1, H3K18la and ELOVL5 levels in HGECs and HK-2 cells. However, AARS1 5M did not have these effects. (*P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001).

Article Snippet: Furthermore, β-alanine (HY-N0230, MCE, China) was used to treat the cells in this study to inhibit AARS1-induced lactylation.

Techniques: Immunofluorescence, Over Expression, Translocation Assay, Western Blot, Phospho-proteomics, Binding Assay, In Vitro, Co-Immunoprecipitation Assay