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4t1 cat crl 2539 cell lines  (ATCC)


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    ATCC 4t1 cat crl 2539 cell lines
    a Measuring the longitudinal relaxation rates ( r 1 ) of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). b Measuring the transverse relaxation rates ( r 2 ) of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). c T 2 -weighted MRI of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). d Dynamic MRI after intravenous injection of RMn-NBs (10 mM × 0.2 mL) in CT26 tumor. The doses of Mn 2+ and RANa are 5.5 mg kg −1 and 30.5 mg kg −1 , respectively ( n = 3 mice). e Relative MRI signal intensities of tumor and kidney regions in the <t>4T1</t> tumor-bearing mice at various time points ( n = 3 mice). The dynamic concentrations of Mn 2+ accumulated within ( f ) tumor and ( g ) kidney in the 4T1 tumor-bearing mice determined by inductively coupled plasma optical emission spectrometer (ICP-OES), respectively ( n = 3 mice). h Pharmacokinetic profiles of free RANa and RMn-NBs in orthotopic 4T1 tumors. The dynamic concentrations of RANa accumulated within ( i ) tumor and ( j ) kidney of 4T1 tumor-bearing mice determined by HPLC, respectively ( n = 3 mice). All data are shown as mean ± SD. Source data are provided as a file.
    4t1 Cat Crl 2539 Cell Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/4t1 cat crl 2539 cell lines/product/ATCC
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    4t1 cat crl 2539 cell lines - by Bioz Stars, 2024-12
    86/100 stars

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    1) Product Images from "Two-dimensional coordination risedronate-manganese nanobelts as adjuvant for cancer radiotherapy and immunotherapy"

    Article Title: Two-dimensional coordination risedronate-manganese nanobelts as adjuvant for cancer radiotherapy and immunotherapy

    Journal: Nature Communications

    doi: 10.1038/s41467-024-53084-w

    a Measuring the longitudinal relaxation rates ( r 1 ) of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). b Measuring the transverse relaxation rates ( r 2 ) of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). c T 2 -weighted MRI of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). d Dynamic MRI after intravenous injection of RMn-NBs (10 mM × 0.2 mL) in CT26 tumor. The doses of Mn 2+ and RANa are 5.5 mg kg −1 and 30.5 mg kg −1 , respectively ( n = 3 mice). e Relative MRI signal intensities of tumor and kidney regions in the 4T1 tumor-bearing mice at various time points ( n = 3 mice). The dynamic concentrations of Mn 2+ accumulated within ( f ) tumor and ( g ) kidney in the 4T1 tumor-bearing mice determined by inductively coupled plasma optical emission spectrometer (ICP-OES), respectively ( n = 3 mice). h Pharmacokinetic profiles of free RANa and RMn-NBs in orthotopic 4T1 tumors. The dynamic concentrations of RANa accumulated within ( i ) tumor and ( j ) kidney of 4T1 tumor-bearing mice determined by HPLC, respectively ( n = 3 mice). All data are shown as mean ± SD. Source data are provided as a file.
    Figure Legend Snippet: a Measuring the longitudinal relaxation rates ( r 1 ) of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). b Measuring the transverse relaxation rates ( r 2 ) of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). c T 2 -weighted MRI of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). d Dynamic MRI after intravenous injection of RMn-NBs (10 mM × 0.2 mL) in CT26 tumor. The doses of Mn 2+ and RANa are 5.5 mg kg −1 and 30.5 mg kg −1 , respectively ( n = 3 mice). e Relative MRI signal intensities of tumor and kidney regions in the 4T1 tumor-bearing mice at various time points ( n = 3 mice). The dynamic concentrations of Mn 2+ accumulated within ( f ) tumor and ( g ) kidney in the 4T1 tumor-bearing mice determined by inductively coupled plasma optical emission spectrometer (ICP-OES), respectively ( n = 3 mice). h Pharmacokinetic profiles of free RANa and RMn-NBs in orthotopic 4T1 tumors. The dynamic concentrations of RANa accumulated within ( i ) tumor and ( j ) kidney of 4T1 tumor-bearing mice determined by HPLC, respectively ( n = 3 mice). All data are shown as mean ± SD. Source data are provided as a file.

    Techniques Used: Injection

    a Schematic illustration of in situ vaccination mediated by RMn-NB-sensitized RT. Created in BioRender. Luo, Z. (2024) BioRender.com/n85g329. b Tumor growth curves, ( c ) isolated tumor photographs, and ( d ) tumor weights of BALB/c mice immunized with Saline + RT and RMn-NBs + RT-treated CT26 tumor cells, respectively ( n = 6 mice). e Percentages of T EM in the spleen analyzed by FCM. The spleens in different groups are collected on day 30 ( n = 6 mice). f Tumor growth curves of 4T1 breast tumor-bearing mice treated with Saline, Saline + RT, RMn-NBs + RT, RMn-NBs + RT + αCD8a and RMn-NBs + RT + αPD-L1 ( n = 6 mice). The doses of Mn 2+ and RANa are 5.5 mg kg −1 and 30.5 mg kg −1 , respectively. X-ray irradiation is performed after intravenous injection of RMn-NBs (10 mM × 0.2 mL) for 6 h. Treatments are performed with 3 fractions (total 6 Gy) on days 0, 3, and 6. αCD8a (10 mg kg −1 ) and αPD-L1 (10 mg kg −1 ) are respectively administered via intraperitoneal injection after RT for 6 h, and treatments are performed on days 0, 3, and 6 ( n = 6 mice). g Weights of 4T1 breast tumor after various treatments ( n = 6 mice). h Survival curves of 4T1 breast tumor-bearing mice ( n = 6 mice). i Quantification of metastatic lesions in the lungs ( n = 6 mice). j Average size of each nodule in the lungs ( n = 6 mice). All data are shown as mean ± SD. Statistical analysis is performed using two-tailed Student’s t -test for comparing two groups, and one-way ANOVA analysis of variance for multiple groups. p > 0.05 represent nonsignificance, while p < 0.05 indicate statistical significance. Source data are provided as a file.
    Figure Legend Snippet: a Schematic illustration of in situ vaccination mediated by RMn-NB-sensitized RT. Created in BioRender. Luo, Z. (2024) BioRender.com/n85g329. b Tumor growth curves, ( c ) isolated tumor photographs, and ( d ) tumor weights of BALB/c mice immunized with Saline + RT and RMn-NBs + RT-treated CT26 tumor cells, respectively ( n = 6 mice). e Percentages of T EM in the spleen analyzed by FCM. The spleens in different groups are collected on day 30 ( n = 6 mice). f Tumor growth curves of 4T1 breast tumor-bearing mice treated with Saline, Saline + RT, RMn-NBs + RT, RMn-NBs + RT + αCD8a and RMn-NBs + RT + αPD-L1 ( n = 6 mice). The doses of Mn 2+ and RANa are 5.5 mg kg −1 and 30.5 mg kg −1 , respectively. X-ray irradiation is performed after intravenous injection of RMn-NBs (10 mM × 0.2 mL) for 6 h. Treatments are performed with 3 fractions (total 6 Gy) on days 0, 3, and 6. αCD8a (10 mg kg −1 ) and αPD-L1 (10 mg kg −1 ) are respectively administered via intraperitoneal injection after RT for 6 h, and treatments are performed on days 0, 3, and 6 ( n = 6 mice). g Weights of 4T1 breast tumor after various treatments ( n = 6 mice). h Survival curves of 4T1 breast tumor-bearing mice ( n = 6 mice). i Quantification of metastatic lesions in the lungs ( n = 6 mice). j Average size of each nodule in the lungs ( n = 6 mice). All data are shown as mean ± SD. Statistical analysis is performed using two-tailed Student’s t -test for comparing two groups, and one-way ANOVA analysis of variance for multiple groups. p > 0.05 represent nonsignificance, while p < 0.05 indicate statistical significance. Source data are provided as a file.

    Techniques Used: In Situ, Isolation, Saline, Irradiation, Injection, Two Tailed Test



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    4t1 cat crl 2539 cell lines  (ATCC)
    86
    ATCC 4t1 cat crl 2539 cell lines
    a Measuring the longitudinal relaxation rates ( r 1 ) of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). b Measuring the transverse relaxation rates ( r 2 ) of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). c T 2 -weighted MRI of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). d Dynamic MRI after intravenous injection of RMn-NBs (10 mM × 0.2 mL) in CT26 tumor. The doses of Mn 2+ and RANa are 5.5 mg kg −1 and 30.5 mg kg −1 , respectively ( n = 3 mice). e Relative MRI signal intensities of tumor and kidney regions in the <t>4T1</t> tumor-bearing mice at various time points ( n = 3 mice). The dynamic concentrations of Mn 2+ accumulated within ( f ) tumor and ( g ) kidney in the 4T1 tumor-bearing mice determined by inductively coupled plasma optical emission spectrometer (ICP-OES), respectively ( n = 3 mice). h Pharmacokinetic profiles of free RANa and RMn-NBs in orthotopic 4T1 tumors. The dynamic concentrations of RANa accumulated within ( i ) tumor and ( j ) kidney of 4T1 tumor-bearing mice determined by HPLC, respectively ( n = 3 mice). All data are shown as mean ± SD. Source data are provided as a file.
    4t1 Cat Crl 2539 Cell Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/4t1 cat crl 2539 cell lines/product/ATCC
    Average 86 stars, based on 1 article reviews
    Price from $9.99 to $1999.99
    4t1 cat crl 2539 cell lines - by Bioz Stars, 2024-12
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    a Measuring the longitudinal relaxation rates ( r 1 ) of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). b Measuring the transverse relaxation rates ( r 2 ) of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). c T 2 -weighted MRI of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). d Dynamic MRI after intravenous injection of RMn-NBs (10 mM × 0.2 mL) in CT26 tumor. The doses of Mn 2+ and RANa are 5.5 mg kg −1 and 30.5 mg kg −1 , respectively ( n = 3 mice). e Relative MRI signal intensities of tumor and kidney regions in the 4T1 tumor-bearing mice at various time points ( n = 3 mice). The dynamic concentrations of Mn 2+ accumulated within ( f ) tumor and ( g ) kidney in the 4T1 tumor-bearing mice determined by inductively coupled plasma optical emission spectrometer (ICP-OES), respectively ( n = 3 mice). h Pharmacokinetic profiles of free RANa and RMn-NBs in orthotopic 4T1 tumors. The dynamic concentrations of RANa accumulated within ( i ) tumor and ( j ) kidney of 4T1 tumor-bearing mice determined by HPLC, respectively ( n = 3 mice). All data are shown as mean ± SD. Source data are provided as a file.

    Journal: Nature Communications

    Article Title: Two-dimensional coordination risedronate-manganese nanobelts as adjuvant for cancer radiotherapy and immunotherapy

    doi: 10.1038/s41467-024-53084-w

    Figure Lengend Snippet: a Measuring the longitudinal relaxation rates ( r 1 ) of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). b Measuring the transverse relaxation rates ( r 2 ) of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). c T 2 -weighted MRI of RMn-NBs and commercial Fe 3 O 4 contrast agent ( n = 3 independent samples). d Dynamic MRI after intravenous injection of RMn-NBs (10 mM × 0.2 mL) in CT26 tumor. The doses of Mn 2+ and RANa are 5.5 mg kg −1 and 30.5 mg kg −1 , respectively ( n = 3 mice). e Relative MRI signal intensities of tumor and kidney regions in the 4T1 tumor-bearing mice at various time points ( n = 3 mice). The dynamic concentrations of Mn 2+ accumulated within ( f ) tumor and ( g ) kidney in the 4T1 tumor-bearing mice determined by inductively coupled plasma optical emission spectrometer (ICP-OES), respectively ( n = 3 mice). h Pharmacokinetic profiles of free RANa and RMn-NBs in orthotopic 4T1 tumors. The dynamic concentrations of RANa accumulated within ( i ) tumor and ( j ) kidney of 4T1 tumor-bearing mice determined by HPLC, respectively ( n = 3 mice). All data are shown as mean ± SD. Source data are provided as a file.

    Article Snippet: The mouse 3T3 (Cat# CRL-1658), CT26 (Cat# CRL-2638), RAW264.7 (Cat# SC-6005), B16F10-OVA (Cat# CRL-6323), and 4T1 (Cat# CRL-2539) cell lines are purchased and authenticated by the American Type Culture Collection (ATCC).

    Techniques: Injection

    a Schematic illustration of in situ vaccination mediated by RMn-NB-sensitized RT. Created in BioRender. Luo, Z. (2024) BioRender.com/n85g329. b Tumor growth curves, ( c ) isolated tumor photographs, and ( d ) tumor weights of BALB/c mice immunized with Saline + RT and RMn-NBs + RT-treated CT26 tumor cells, respectively ( n = 6 mice). e Percentages of T EM in the spleen analyzed by FCM. The spleens in different groups are collected on day 30 ( n = 6 mice). f Tumor growth curves of 4T1 breast tumor-bearing mice treated with Saline, Saline + RT, RMn-NBs + RT, RMn-NBs + RT + αCD8a and RMn-NBs + RT + αPD-L1 ( n = 6 mice). The doses of Mn 2+ and RANa are 5.5 mg kg −1 and 30.5 mg kg −1 , respectively. X-ray irradiation is performed after intravenous injection of RMn-NBs (10 mM × 0.2 mL) for 6 h. Treatments are performed with 3 fractions (total 6 Gy) on days 0, 3, and 6. αCD8a (10 mg kg −1 ) and αPD-L1 (10 mg kg −1 ) are respectively administered via intraperitoneal injection after RT for 6 h, and treatments are performed on days 0, 3, and 6 ( n = 6 mice). g Weights of 4T1 breast tumor after various treatments ( n = 6 mice). h Survival curves of 4T1 breast tumor-bearing mice ( n = 6 mice). i Quantification of metastatic lesions in the lungs ( n = 6 mice). j Average size of each nodule in the lungs ( n = 6 mice). All data are shown as mean ± SD. Statistical analysis is performed using two-tailed Student’s t -test for comparing two groups, and one-way ANOVA analysis of variance for multiple groups. p > 0.05 represent nonsignificance, while p < 0.05 indicate statistical significance. Source data are provided as a file.

    Journal: Nature Communications

    Article Title: Two-dimensional coordination risedronate-manganese nanobelts as adjuvant for cancer radiotherapy and immunotherapy

    doi: 10.1038/s41467-024-53084-w

    Figure Lengend Snippet: a Schematic illustration of in situ vaccination mediated by RMn-NB-sensitized RT. Created in BioRender. Luo, Z. (2024) BioRender.com/n85g329. b Tumor growth curves, ( c ) isolated tumor photographs, and ( d ) tumor weights of BALB/c mice immunized with Saline + RT and RMn-NBs + RT-treated CT26 tumor cells, respectively ( n = 6 mice). e Percentages of T EM in the spleen analyzed by FCM. The spleens in different groups are collected on day 30 ( n = 6 mice). f Tumor growth curves of 4T1 breast tumor-bearing mice treated with Saline, Saline + RT, RMn-NBs + RT, RMn-NBs + RT + αCD8a and RMn-NBs + RT + αPD-L1 ( n = 6 mice). The doses of Mn 2+ and RANa are 5.5 mg kg −1 and 30.5 mg kg −1 , respectively. X-ray irradiation is performed after intravenous injection of RMn-NBs (10 mM × 0.2 mL) for 6 h. Treatments are performed with 3 fractions (total 6 Gy) on days 0, 3, and 6. αCD8a (10 mg kg −1 ) and αPD-L1 (10 mg kg −1 ) are respectively administered via intraperitoneal injection after RT for 6 h, and treatments are performed on days 0, 3, and 6 ( n = 6 mice). g Weights of 4T1 breast tumor after various treatments ( n = 6 mice). h Survival curves of 4T1 breast tumor-bearing mice ( n = 6 mice). i Quantification of metastatic lesions in the lungs ( n = 6 mice). j Average size of each nodule in the lungs ( n = 6 mice). All data are shown as mean ± SD. Statistical analysis is performed using two-tailed Student’s t -test for comparing two groups, and one-way ANOVA analysis of variance for multiple groups. p > 0.05 represent nonsignificance, while p < 0.05 indicate statistical significance. Source data are provided as a file.

    Article Snippet: The mouse 3T3 (Cat# CRL-1658), CT26 (Cat# CRL-2638), RAW264.7 (Cat# SC-6005), B16F10-OVA (Cat# CRL-6323), and 4T1 (Cat# CRL-2539) cell lines are purchased and authenticated by the American Type Culture Collection (ATCC).

    Techniques: In Situ, Isolation, Saline, Irradiation, Injection, Two Tailed Test