iwp 2 (ReproCELL)

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Structured Review

ReproCELL iwp 2
Iwp 2, supplied by ReproCELL, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/04-0034/Stemolecule+Wnt+Inhibitor+IWP-2/bio_rxiv__2024__11__26__624368-274-30-31
Average 93 stars, based on 1 article reviews

iwp 2 - by Bioz Stars, 2026-09

93/100 stars

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Cell Culture:

Article Title: iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage.
Article Snippet: Endodermal cells were first washed with XFM– and then cultured for 24 h in XFM– supplemented with 1 μM A8301 (Stemgent, 04-0014) and 250 nM of LDN193189. .. The following day, cells were washed in XFM– and cultured in XFM– supplemented with 1 μM A8301 and 1 μM IWP2 (Stemgent, 04-0034). .. From day 6 to day 16, we switched to XFM+, which contained the same components as XFM– except that the B-27 supplement without insulin was replaced with a B-27 supplement with insulin (Thermo Fisher Scientific, 17504044).

Article Title: iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage
Article Snippet: Endodermal cells were first washed with XFM– and then cultured for 24 h in XFM– supplemented with 1 μM A8301 (Stemgent, 04-0014) and 250 nM of LDN193189. .. The following day, cells were washed in XFM– and cultured in XFM– supplemented with 1 μM A8301 and 1 μM IWP2 (Stemgent, 04-0034). .. From day 6 to day 16, we switched to XFM+, which contained the same components as XFM– except that the B-27 supplement without insulin was replaced with a B-27 supplement with insulin (Thermo Fisher Scientific, 17504044).

other:

Article Title: Chemotherapy-Free Targeted Anti-BCR-ABL+ Acute Lymphoblastic Leukemia Therapy May Benefit the Heart
Article Snippet: Precisely 24 h later, the medium was replaced by CDM3 supplemented with a 5 mM inhibitor of Wnt production 2 (IWP2) (ReproCell, Betsville, MD, USA); 48 h later, the medium was replaced with pure CDM3; fresh CDM3 medium was added every 2–3 days thereafter.

Article Title: Cortical assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects
Article Snippet: At 18-24hours after plating, organoids were washed 1x with PBS and treated with 100nM LDN193189 (Stemgent #04-0074) and 10uM SB431542 (R&D #1614) and either 5uM XAV939 for dFB or 4uM IWP-2 (Stemgent #04-0034) for vFB in Essential 6 Media (Thermo #A1516401).

Protein-Protein interactions:

Article Title: In vitro production of medial ganglionic eminence precursor cells
Article Snippet: FIG. 24, C: B27+5F differentiation protocol with LDN193189 (0.1 μM, Catalog #04-0019 (Stemgent)) and IWIR1e (3 μM, Cayman Chemical Catalog #13659) as inhibitors of BMP and WNT signaling pathways, respectively, induced differentiation of hESCs into MGE precursor cells that co-express NKX2.1GFP (top) and FOXG1 (bottom). .. FIG. 24, D: B27+5F differentiation protocol with LDN193189 (0.1 μM, Catalog #04-0019 (Stemgent)) and IWP2 (5 μM, Stemgent Catalog #04-0034) as inhibitors of BMP and WNT signaling pathways, respectively, induced differentiation of hESCs into MGE precursor cells that co-express NKX2.1GFP (top) and LHX6 (bottom). .. FIG. 24, E: B27+5F differentiation protocol with Dorsamorphin (1 μM, Sigma Catalog #P5499) and (CKI)-7 (1 μM, Sigma Catalog #D0742) as inhibitors of BMP and WNT signaling pathways, respectively, induced differentiation of hESCs into MGE precursor cells that co-express NKX2.1GFP and NKX2.1.

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iwp 2 (ReproCELL)

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