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Structured Review

ReproCELL iwp 2
Iwp 2, supplied by ReproCELL, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/04-0034/Stemolecule+Wnt+Inhibitor+IWP-2/bio_rxiv__2024__11__26__624368-274-30-31
Average 93 stars, based on 1 article reviews
iwp 2 - by Bioz Stars, 2026-09
93/100 stars

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Article Title: Chemotherapy-Free Targeted Anti-BCR-ABL+ Acute Lymphoblastic Leukemia Therapy May Benefit the Heart
Article Snippet: Precisely 24 h later, the medium was replaced by CDM3 supplemented with a 5 mM inhibitor of Wnt production 2 (IWP2) (ReproCell, Betsville, MD, USA); 48 h later, the medium was replaced with pure CDM3; fresh CDM3 medium was added every 2–3 days thereafter.

Article Title: Cortical assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects
Article Snippet: At 18-24hours after plating, organoids were washed 1x with PBS and treated with 100nM LDN193189 (Stemgent #04-0074) and 10uM SB431542 (R&D #1614) and either 5uM XAV939 for dFB or 4uM IWP-2 (Stemgent #04-0034) for vFB in Essential 6 Media (Thermo #A1516401).

Article Title: WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids
Article Snippet: Small molecules were used at the following concentrations and were replaced every 24 hr: 10 mM SB431542 (Stemgent), 1 mM IWP-2 (Stemgent), and 1 mM endo-IWR-1 (Tocris).

Cell Culture:

Article Title: Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant
Article Snippet: .. foregut endoderm induction (days 3–5), the cells were cultured in SFD medium supplemented with 1.5 μM dorsomorphin dihydrochloride (FUJIFILM Wako Pure Chemical, Cat# 047-33763) and 10 μM SB431542 (FUJIFILM Wako Pure Chemical, Cat# 037-24293) for 24 h and then in SFD medium supplemented with 10 μM SB431542 and 1 μM IWP2 (REPROCELL) for another 24 h. For the induction of lung progenitors (days 5–12), the resulting anterior foregut endoderm was cultured with SFD medium supplemented with 3 μM CHIR99021 (FUJIFILM Wako Pure Chemical, Cat# 032-23104), 10 ng/mL human FGF10 (PeproTech, Cat# 100-26), 10 ng/mL human FGF7 (PeproTech, Cat# 100-19), 10 ng/mL human BMP4 (PeproTech, Cat# 120-05ET), 20 ng/mL human EGF (PeproTech, Cat# AF100-15), and all-trans retinoic acid (ATRA, Sigma-Aldrich, Cat# R2625) for 7 days. ..



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