taurine antagonist (Tocris)

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Tocris taurine antagonist
Taurine Antagonist, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 30 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/0209/Taurine/pmc12328231-429-0-24
Average 93 stars, based on 30 article reviews

taurine antagonist - by Bioz Stars, 2026-09

93/100 stars

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Article Title: Retinal Organoids from an AIPL1 CRISPR/Cas9 Knockout Cell Line Successfully Recapitulate the Molecular Features of LCA4 Disease.
Article Snippet: NRVs were manually excised using 21G needles/scalpel blades and grown in lowbinding 96-well plates (96-well Nunc Sphera Round Bottom Plates, Thermo Fisher Scientific) in retinal differentiation media (DMEM/F12 nutrient mix (3:1 ratio; Gibco), 10% foetal bovine serum (FBS; Gibco), 2% B27 supplement (without vitamin A; Gibco), 100 μM taurine (Tocris, Abingdon, UK), 2 mM GlutaMAX (Gibco, Loughborough, UK) and 100 U/mL penicillin/streptomycin (Gibco, Loughborough, UK)), with media changes every 2 days.

Article Title: Identification and pharmacological modification of resistance mechanisms to protoporphyrin-mediated photodynamic therapy in human cutaneous squamous cell carcinoma cell lines.
Article Snippet: Background: Photodynamic therapy (PDT) is clinically approved to treat neoplastic skin diseases such as precursors of cutaneous squamous cell carcinoma (cSCC).. In PDT, 5-aminolevulinic acid (5-ALA) drives the selective formation of the endogenous photosensitizer protoporphyrin IX (PpIX).. Although 5-ALA PDT is clinically highly effective, resistance might occur due to decreased accumulation of PpIX in certain tumors.

Article Title: Feline Adipose Derived Multipotent Stromal Cell Transdifferentiation Into Functional Insulin Producing Cell Clusters
Article Snippet: DMEM/F-12, 1.5% BSA, 1.5 × ITS, 3 mM taurine, 100 nM glucagon-like peptide 1 (GLP-1, Tocris Bioscience, Ellisville, MO, United States), 1 mM nicotinamide (ACROS Organics), 1 × non-essential amino acids (NEAA, Gibco), 10 nM pentagastrin (Tocris Bioscience), 1% N-2 supplement, 1% B-27 supplement, 50 ng/ml HGF, 20 ng/ml bFGF, 5 μg/ml laminin, 20 ng/ml betacellulin (R&D Systems), 10 nM extendin-4 (Tocris Bioscience).

Article Title: Retinal Organoids from an AIPL1 CRISPR/Cas9 Knockout Cell Line Successfully Recapitulate the Molecular Features of LCA4 Disease
Article Snippet: NRVs were manually excised using 21G needles/scalpel blades and grown in low-binding 96-well plates (96-well Nunc Sphera Round Bottom Plates, Thermo Fisher Scientific) in retinal differentiation media (DMEM/F12 nutrient mix (3:1 ratio; Gibco), 10% foetal bovine serum (FBS; Gibco), 2% B27 supplement (without vitamin A; Gibco), 100 μM taurine (Tocris, Abingdon, UK), 2 mM GlutaMAX (Gibco, Loughborough, UK) and 100 U/mL penicillin/streptomycin (Gibco, Loughborough, UK)), with media changes every 2 days.

Cell Culture:

Article Title: Effective AAV-mediated gene replacement therapy in retinal organoids modeling AIPL1-associated LCA4
Article Snippet: Directed differentiation of iPSCs into 3D ROs was carried out as previously described., In brief, differentiation began with iPSCs at 90%–95% confluency, which were cultured in Essential 6 media (Gibco) for 2 days then Neural Induction Media (Advanced DMEM/F12 (1:1), 1% non-essential amino acids, 1% N2 Supplement, 1% GlutaMAX, 1% Antibiotic-Antimycotic (all Gibco)) until development of neuroretinal vesicles (NRVs), typically between day 28 and 42. .. NRVs were manually excised then cultured further in Retinal Differentiation Media (DMEM/F12 nutrient mix (3:1 ratio; Gibco), 10% fetal bovine serum (Gibco), 2% B27 supplement (without vitamin A; Gibco), 100 μM taurine (Tocris, Abingdon, UK), 2 mM GlutaMAX (Gibco), and 100 U/mL penicillin/streptomycin (Gibco)), with media changes every 2 days. ..

Synthesized:

Article Title: Taurine from tumour niche drives glycolysis to promote leukaemogenesis
Article Snippet: .. Taurine antagonist or TAG (synthesized by Enamine; 92% pure), GES (G827500, Toronto Research Chemicals), taurine (T8691, Sigma-Aldrich), mTOR activator (MHY1485, Sigma-Aldrich) and Venetoclax (ABT-199, Tocris Bioscience) were used as described. ..

Article Title: Temporal Single Cell Analysis of Leukemia Microenvironment Identifies Taurine-Taurine Transporter Axis as a Key Regulator of Myeloid Leukemia
Article Snippet: .. Taurine antagonist or TAG (synthesized by Enamine Inc.; 92% pure), mTOR activator (MHY1485; Sigma-Aldrich) and Venetoclax (ABT-199; Tocris Bioscience) were used as described. .. Seahorse XF Glycolysis Stress Test Kit (Agilent Technologies, 103020-100) and Seahorse XF cell mito stress test kit (Agilent Technologies, 103015-100) were used to measure glycolytic flux (ECAR) and oxygen consumption (OCR) respectively.

Recombinant:

Article Title: Functional feline pancreatic cells from adipose tissue
Article Snippet: .. TABLE 1 Composition of induction medium for differentiation Medium Composition Adipogenic Minimum essential medium alpha (α-MEM), 10% rabbit serum, medium 10% FBS, 10 nM dexamethasone, 5 μg/ml insulin, 50 μM 5,8,11,14-eicosatetraynoic acid (ETYA, Cayman, Ann Arbor, MI), 100 μM indomethacin Osteogenic DMEM, 10% FBS, 100 nM dexamethasone, 0.25 mM L-ascorbic preinduction acid medium Osteogenic Osteogenic preinduction medium supplemented with 10 mM β- induction glycerophosphate medium β-cell induction Stage 1: medium SFM 1 (2 days): DMEM, 17.5 mM glucose, 1% BSA (bovine serum albumin), 1 × insulin-transferrin-selenium (ITS, Gibco BRL, Gaithersburg, MD), 4 nM activin A (R&D Systems Inc., Minneapolis), 1 mM sodium butyrate, 50 μM 2-mercapethanol, 1% N-2 supplement (R&D Systems Inc.), 1% B-27 supplement (Gibco), 5 μg/ml laminin (Corning), 50 ng/ml recombinant human hepatocyte growth factor (HGF, EMD Millipore, Temecula, CA), 20 ng/ml basic fibroblast growth factor (bFGF, Gibco); Stage 2: SFM 2 (6 days): DMEM, 17.5 mM glucose, 1% BSA, 1 × ITS, 0.3 mM taurine (ACROS Organics, Morris Plains, NJ), 5 μg/ml laminin, 20 ng/ml bFGF, 1% N-2 supplement, 1% B-27 supplement, 50 ng/ml HGF; Stage 3 SFM 3 (4 days): DMEM, 17.5 mM glucose, 1.5% BSA, 1.5 × ITS, 3 mM taurine, 100 nM glucagon-like peptide 1 (GLP-1, TOCRIS bioscience, Ellisville, MO), 1 mM nicotinamide (ACROS Organics), 1 × non-essential amino acids (NEAA, Gibco), 10 nM pentagastrin (TOCRIS bioscience), 1% N-2 supplement, 1% B-27 supplement, 50 ng/ml HGF, 20 ng/ml bFGF, 5 μg/ml laminin, 10 ng/ml betacellulin (R&D Systems) .. Following the induction process, cells were incubated with dithizone (DTZ, Fisher Scientific, Fairlawn, N.J.) solution (10 μl DTZ working solution (1 mg/ml in dimethyl sulfoxide (Fisher Scientific)) in 1 ml of the culture medium) for 30 min at 37° C. Cells were washed in PBS after incubation and imaged with light microscope.

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