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ribozyme-based inverse genomics platform identification drug target genes  (Immusol Inc)

 
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    Immusol Inc ribozyme-based inverse genomics platform identification drug target genes
    Ribozyme Based Inverse Genomics Platform Identification Drug Target Genes, supplied by Immusol Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/zebrafish+microarray+platform/ribozyme+based+inverse+genomics+platform+identification+drug+target+genes/pm15014515-142-29-31
    Average 90 stars, based on 1 article reviews
    ribozyme-based inverse genomics platform identification drug target genes - by Bioz Stars, 2026-11
    90/100 stars

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    Related Articles

    Software:

    Article Title: Drug target identification: a question of biology.
    Article Snippet: Aclara BioSciences LabCard microfluidics ‘lab-on-a-chip’ systems for biochemical and cellular analysis, Mountain View, California www.aclara.com including multiplexed gene-expression analysis Affymetrix GeneChip microarray systems, including human whole-genome DNA microarray; Santa Clara, California www.affymetrix.com microarray scanners and readers Agilent Workstation for RNA, DNA or protein analysis; human whole-genome DNA microarray; Palo Alto, California www.agilent.com instruments for genomics and proteomics Althea Technologies PCR-based high-throughput gene-expression profiling San Diego, California www.altheatech.com Capital Genomix GeneSystem 320 differential gene-expression profiling; custom antibodies; Chantilly,Virginia www.capitalgenomix.com microarray services Celera Discovery System web-based informatics tools for accessing the Celera annotated Rockville, Maryland www.celera.com genomes databases; bioinformatics services; DNA sequencing; target validation Chromagen Fluorescence based products, kits and services for gene expression and protein San Diego, California www.chromagen.com detection and assay Curagen GeneScape portal for genome analysis tools; proteomics research for drug target discovery; Branford, Connecticut www.curagen.com proteome interaction map for Drosophila GeneFormatics Genomics-based drug target discovery San Diego, California www.geneformatics.com Genomic Solutions Automated instrumentation for genomics and proteomics, software, consumables Ann Arbor, Michigan www.genomicsolutions.com and services.

    Sequencing:

    Article Title: Drug target identification: a question of biology.
    Article Snippet: Aclara BioSciences LabCard microfluidics ‘lab-on-a-chip’ systems for biochemical and cellular analysis, Mountain View, California www.aclara.com including multiplexed gene-expression analysis Affymetrix GeneChip microarray systems, including human whole-genome DNA microarray; Santa Clara, California www.affymetrix.com microarray scanners and readers Agilent Workstation for RNA, DNA or protein analysis; human whole-genome DNA microarray; Palo Alto, California www.agilent.com instruments for genomics and proteomics Althea Technologies PCR-based high-throughput gene-expression profiling San Diego, California www.altheatech.com Capital Genomix GeneSystem 320 differential gene-expression profiling; custom antibodies; Chantilly,Virginia www.capitalgenomix.com microarray services Celera Discovery System web-based informatics tools for accessing the Celera annotated Rockville, Maryland www.celera.com genomes databases; bioinformatics services; DNA sequencing; target validation Chromagen Fluorescence based products, kits and services for gene expression and protein San Diego, California www.chromagen.com detection and assay Curagen GeneScape portal for genome analysis tools; proteomics research for drug target discovery; Branford, Connecticut www.curagen.com proteome interaction map for Drosophila GeneFormatics Genomics-based drug target discovery San Diego, California www.geneformatics.com Genomic Solutions Automated instrumentation for genomics and proteomics, software, consumables Ann Arbor, Michigan www.genomicsolutions.com and services.

    Microarray:

    Article Title: Drug target identification: a question of biology.
    Article Snippet: Aclara BioSciences LabCard microfluidics ‘lab-on-a-chip’ systems for biochemical and cellular analysis, Mountain View, California www.aclara.com including multiplexed gene-expression analysis Affymetrix GeneChip microarray systems, including human whole-genome DNA microarray; Santa Clara, California www.affymetrix.com microarray scanners and readers Agilent Workstation for RNA, DNA or protein analysis; human whole-genome DNA microarray; Palo Alto, California www.agilent.com instruments for genomics and proteomics Althea Technologies PCR-based high-throughput gene-expression profiling San Diego, California www.altheatech.com Capital Genomix GeneSystem 320 differential gene-expression profiling; custom antibodies; Chantilly,Virginia www.capitalgenomix.com microarray services Celera Discovery System web-based informatics tools for accessing the Celera annotated Rockville, Maryland www.celera.com genomes databases; bioinformatics services; DNA sequencing; target validation Chromagen Fluorescence based products, kits and services for gene expression and protein San Diego, California www.chromagen.com detection and assay Curagen GeneScape portal for genome analysis tools; proteomics research for drug target discovery; Branford, Connecticut www.curagen.com proteome interaction map for Drosophila GeneFormatics Genomics-based drug target discovery San Diego, California www.geneformatics.com Genomic Solutions Automated instrumentation for genomics and proteomics, software, consumables Ann Arbor, Michigan www.genomicsolutions.com and services.

    Oligonucleotide Synthesis:

    Article Title: Drug target identification: a question of biology.
    Article Snippet: Aclara BioSciences LabCard microfluidics ‘lab-on-a-chip’ systems for biochemical and cellular analysis, Mountain View, California www.aclara.com including multiplexed gene-expression analysis Affymetrix GeneChip microarray systems, including human whole-genome DNA microarray; Santa Clara, California www.affymetrix.com microarray scanners and readers Agilent Workstation for RNA, DNA or protein analysis; human whole-genome DNA microarray; Palo Alto, California www.agilent.com instruments for genomics and proteomics Althea Technologies PCR-based high-throughput gene-expression profiling San Diego, California www.altheatech.com Capital Genomix GeneSystem 320 differential gene-expression profiling; custom antibodies; Chantilly,Virginia www.capitalgenomix.com microarray services Celera Discovery System web-based informatics tools for accessing the Celera annotated Rockville, Maryland www.celera.com genomes databases; bioinformatics services; DNA sequencing; target validation Chromagen Fluorescence based products, kits and services for gene expression and protein San Diego, California www.chromagen.com detection and assay Curagen GeneScape portal for genome analysis tools; proteomics research for drug target discovery; Branford, Connecticut www.curagen.com proteome interaction map for Drosophila GeneFormatics Genomics-based drug target discovery San Diego, California www.geneformatics.com Genomic Solutions Automated instrumentation for genomics and proteomics, software, consumables Ann Arbor, Michigan www.genomicsolutions.com and services.

    Expressing:

    Article Title: Drug target identification: a question of biology.
    Article Snippet: Aclara BioSciences LabCard microfluidics ‘lab-on-a-chip’ systems for biochemical and cellular analysis, Mountain View, California www.aclara.com including multiplexed gene-expression analysis Affymetrix GeneChip microarray systems, including human whole-genome DNA microarray; Santa Clara, California www.affymetrix.com microarray scanners and readers Agilent Workstation for RNA, DNA or protein analysis; human whole-genome DNA microarray; Palo Alto, California www.agilent.com instruments for genomics and proteomics Althea Technologies PCR-based high-throughput gene-expression profiling San Diego, California www.altheatech.com Capital Genomix GeneSystem 320 differential gene-expression profiling; custom antibodies; Chantilly,Virginia www.capitalgenomix.com microarray services Celera Discovery System web-based informatics tools for accessing the Celera annotated Rockville, Maryland www.celera.com genomes databases; bioinformatics services; DNA sequencing; target validation Chromagen Fluorescence based products, kits and services for gene expression and protein San Diego, California www.chromagen.com detection and assay Curagen GeneScape portal for genome analysis tools; proteomics research for drug target discovery; Branford, Connecticut www.curagen.com proteome interaction map for Drosophila GeneFormatics Genomics-based drug target discovery San Diego, California www.geneformatics.com Genomic Solutions Automated instrumentation for genomics and proteomics, software, consumables Ann Arbor, Michigan www.genomicsolutions.com and services.



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    Image Search Results


    Of 12261 potential unique genes, the mRNA expression of 1313 were found to be statistically significantly changed at 24 hpf, with 583 downregulated (grey) and 730 upregulated (black). 836 genes were changed with statistical significance at 36 hpf, of which 243 were downregulated and 593 were upregulated. (n=3 pools of 25 embryos used for microarray analysis, P≤0.05, Students t -test with Benjamini-Hochberg false-discovery rate correction).

    Journal: PLoS ONE

    Article Title: The Transcriptomics of Glucocorticoid Receptor Signaling in Developing Zebrafish

    doi: 10.1371/journal.pone.0080726

    Figure Lengend Snippet: Of 12261 potential unique genes, the mRNA expression of 1313 were found to be statistically significantly changed at 24 hpf, with 583 downregulated (grey) and 730 upregulated (black). 836 genes were changed with statistical significance at 36 hpf, of which 243 were downregulated and 593 were upregulated. (n=3 pools of 25 embryos used for microarray analysis, P≤0.05, Students t -test with Benjamini-Hochberg false-discovery rate correction).

    Article Snippet: To better understand of the molecular mechanisms involved, we investigated changes in the developmental transcriptome prior to hatch, in response to morpholino oligonucleotide knockdown of GR using the Agilent zebrafish microarray platform.

    Techniques: Expressing, Microarray

    qPCR analysis was performed on 7 genes to confirm the transcript abundance seen with the microarray analysis. The selected genes were bmp7a (A), f5 (B) , ff1d (C), myom1a (D), pomca (E), star (F), mc1r (G). Data is presented as mean ± standard error of the mean (normalized to β-actin, SEM; n=5-7 pools of 25 embryos each); * denotes statistical significance ( t -test, p<0.05). (See for fold-changes and p-values).

    Journal: PLoS ONE

    Article Title: The Transcriptomics of Glucocorticoid Receptor Signaling in Developing Zebrafish

    doi: 10.1371/journal.pone.0080726

    Figure Lengend Snippet: qPCR analysis was performed on 7 genes to confirm the transcript abundance seen with the microarray analysis. The selected genes were bmp7a (A), f5 (B) , ff1d (C), myom1a (D), pomca (E), star (F), mc1r (G). Data is presented as mean ± standard error of the mean (normalized to β-actin, SEM; n=5-7 pools of 25 embryos each); * denotes statistical significance ( t -test, p<0.05). (See for fold-changes and p-values).

    Article Snippet: To better understand of the molecular mechanisms involved, we investigated changes in the developmental transcriptome prior to hatch, in response to morpholino oligonucleotide knockdown of GR using the Agilent zebrafish microarray platform.

    Techniques: Microarray

    List of genes confirmed using microarray and qPCR with fold-changes and p-values.

    Journal: PLoS ONE

    Article Title: The Transcriptomics of Glucocorticoid Receptor Signaling in Developing Zebrafish

    doi: 10.1371/journal.pone.0080726

    Figure Lengend Snippet: List of genes confirmed using microarray and qPCR with fold-changes and p-values.

    Article Snippet: To better understand of the molecular mechanisms involved, we investigated changes in the developmental transcriptome prior to hatch, in response to morpholino oligonucleotide knockdown of GR using the Agilent zebrafish microarray platform.

    Techniques: Microarray