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way 262611  (MedChemExpress)


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    MedChemExpress way 262611
    DKK1 regulates HG-induced dysfunction in HLECs via Wnt/β-catenin signaling. ( A , B ) Wound healing of HLECs under NG and HG conditions with DMSO <t>or</t> <t>WAY-262611</t> supplement after 12 hours. Scale bar : 200 µm. ( C , D ) Flow cytometry revealed the cell cycle of HLECs under NG or HG conditions with DMSO or WAY-262611 supplement. ( E ) Proliferation of HLECs under NG or HG conditions with DMSO or WAY-262611 supplement. ( F , G ) Rat lenses were extracted and cultivated in 150-mM glucose or 150-mM mannitol media for 7 days. The addition of WAY-262611 to the HG-stressed lenses prevented the formation of cataracts ( n = 3 per group). Scale bar : 1000 µm. Data are representative of three independent experiments. The data are presented as mean ± SD ( n = 3). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, as compared with the control group.
    Way 262611, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/way 262611/product/MedChemExpress
    Average 94 stars, based on 14 article reviews
    way 262611 - by Bioz Stars, 2026-03
    94/100 stars

    Images

    1) Product Images from "METTL16 Inhibits Lens Epithelial Cells Function in Diabetic Cataract via m 6 A-Modified DKK1-Mediated Wnt/β-Catenin Signaling"

    Article Title: METTL16 Inhibits Lens Epithelial Cells Function in Diabetic Cataract via m 6 A-Modified DKK1-Mediated Wnt/β-Catenin Signaling

    Journal: Investigative Ophthalmology & Visual Science

    doi: 10.1167/iovs.67.1.1

    DKK1 regulates HG-induced dysfunction in HLECs via Wnt/β-catenin signaling. ( A , B ) Wound healing of HLECs under NG and HG conditions with DMSO or WAY-262611 supplement after 12 hours. Scale bar : 200 µm. ( C , D ) Flow cytometry revealed the cell cycle of HLECs under NG or HG conditions with DMSO or WAY-262611 supplement. ( E ) Proliferation of HLECs under NG or HG conditions with DMSO or WAY-262611 supplement. ( F , G ) Rat lenses were extracted and cultivated in 150-mM glucose or 150-mM mannitol media for 7 days. The addition of WAY-262611 to the HG-stressed lenses prevented the formation of cataracts ( n = 3 per group). Scale bar : 1000 µm. Data are representative of three independent experiments. The data are presented as mean ± SD ( n = 3). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, as compared with the control group.
    Figure Legend Snippet: DKK1 regulates HG-induced dysfunction in HLECs via Wnt/β-catenin signaling. ( A , B ) Wound healing of HLECs under NG and HG conditions with DMSO or WAY-262611 supplement after 12 hours. Scale bar : 200 µm. ( C , D ) Flow cytometry revealed the cell cycle of HLECs under NG or HG conditions with DMSO or WAY-262611 supplement. ( E ) Proliferation of HLECs under NG or HG conditions with DMSO or WAY-262611 supplement. ( F , G ) Rat lenses were extracted and cultivated in 150-mM glucose or 150-mM mannitol media for 7 days. The addition of WAY-262611 to the HG-stressed lenses prevented the formation of cataracts ( n = 3 per group). Scale bar : 1000 µm. Data are representative of three independent experiments. The data are presented as mean ± SD ( n = 3). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, as compared with the control group.

    Techniques Used: Flow Cytometry, Control



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    Image Search Results


    DKK1 regulates HG-induced dysfunction in HLECs via Wnt/β-catenin signaling. ( A , B ) Wound healing of HLECs under NG and HG conditions with DMSO or WAY-262611 supplement after 12 hours. Scale bar : 200 µm. ( C , D ) Flow cytometry revealed the cell cycle of HLECs under NG or HG conditions with DMSO or WAY-262611 supplement. ( E ) Proliferation of HLECs under NG or HG conditions with DMSO or WAY-262611 supplement. ( F , G ) Rat lenses were extracted and cultivated in 150-mM glucose or 150-mM mannitol media for 7 days. The addition of WAY-262611 to the HG-stressed lenses prevented the formation of cataracts ( n = 3 per group). Scale bar : 1000 µm. Data are representative of three independent experiments. The data are presented as mean ± SD ( n = 3). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, as compared with the control group.

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    Article Title: METTL16 Inhibits Lens Epithelial Cells Function in Diabetic Cataract via m 6 A-Modified DKK1-Mediated Wnt/β-Catenin Signaling

    doi: 10.1167/iovs.67.1.1

    Figure Lengend Snippet: DKK1 regulates HG-induced dysfunction in HLECs via Wnt/β-catenin signaling. ( A , B ) Wound healing of HLECs under NG and HG conditions with DMSO or WAY-262611 supplement after 12 hours. Scale bar : 200 µm. ( C , D ) Flow cytometry revealed the cell cycle of HLECs under NG or HG conditions with DMSO or WAY-262611 supplement. ( E ) Proliferation of HLECs under NG or HG conditions with DMSO or WAY-262611 supplement. ( F , G ) Rat lenses were extracted and cultivated in 150-mM glucose or 150-mM mannitol media for 7 days. The addition of WAY-262611 to the HG-stressed lenses prevented the formation of cataracts ( n = 3 per group). Scale bar : 1000 µm. Data are representative of three independent experiments. The data are presented as mean ± SD ( n = 3). * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, as compared with the control group.

    Article Snippet: WAY-262611 (MedChemExpress, Monmouth Junction, NJ, USA), a DKK1 inhibitor, was prepared as a stock solution in dimethyl sulfoxide (DMSO) at a concentration of 1 mM.

    Techniques: Flow Cytometry, Control