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panitumumab (vectibix)  (Amgen)

 
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    Structured Review

    Amgen panitumumab (vectibix)
    Binding of increasing concentrations of panitumumab-[ 197 Hg]Hg-AuNPs to U251-Luc cells in the absence (total binding; TB) or presence of an excess of panitumumab (non-specific binding; NSB). Specific binding (SB) was calculated by subtracting NSB from TB. Fitting the SB curve to a one-site receptor binding model, the estimated K D = 1.8 × 10 –9 mol/L and B max = 47.44 fmole, corresponding to 1.1 × 10 5 <t>EGFR/cell</t>
    Panitumumab (Vectibix), supplied by Amgen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/panitumumab (vectibix)/product/Amgen
    Average 90 stars, based on 1 article reviews
    panitumumab (vectibix) - by Bioz Stars, 2026-02
    90/100 stars

    Images

    1) Product Images from "Auger electron-emitting EGFR-targeted and non-targeted [ 197 Hg]Hg-gold nanoparticles for treatment of glioblastoma multiforme (GBM)"

    Article Title: Auger electron-emitting EGFR-targeted and non-targeted [ 197 Hg]Hg-gold nanoparticles for treatment of glioblastoma multiforme (GBM)

    Journal: EJNMMI Radiopharmacy and Chemistry

    doi: 10.1186/s41181-025-00367-2

    Binding of increasing concentrations of panitumumab-[ 197 Hg]Hg-AuNPs to U251-Luc cells in the absence (total binding; TB) or presence of an excess of panitumumab (non-specific binding; NSB). Specific binding (SB) was calculated by subtracting NSB from TB. Fitting the SB curve to a one-site receptor binding model, the estimated K D = 1.8 × 10 –9 mol/L and B max = 47.44 fmole, corresponding to 1.1 × 10 5 EGFR/cell
    Figure Legend Snippet: Binding of increasing concentrations of panitumumab-[ 197 Hg]Hg-AuNPs to U251-Luc cells in the absence (total binding; TB) or presence of an excess of panitumumab (non-specific binding; NSB). Specific binding (SB) was calculated by subtracting NSB from TB. Fitting the SB curve to a one-site receptor binding model, the estimated K D = 1.8 × 10 –9 mol/L and B max = 47.44 fmole, corresponding to 1.1 × 10 5 EGFR/cell

    Techniques Used: Binding Assay



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    vectibix  (Amgen)
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    Binding of increasing concentrations of panitumumab-[ 197 Hg]Hg-AuNPs to U251-Luc cells in the absence (total binding; TB) or presence of an excess of panitumumab (non-specific binding; NSB). Specific binding (SB) was calculated by subtracting NSB from TB. Fitting the SB curve to a one-site receptor binding model, the estimated K D = 1.8 × 10 –9 mol/L and B max = 47.44 fmole, corresponding to 1.1 × 10 5 <t>EGFR/cell</t>
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    Image Search Results


    Binding of increasing concentrations of panitumumab-[ 197 Hg]Hg-AuNPs to U251-Luc cells in the absence (total binding; TB) or presence of an excess of panitumumab (non-specific binding; NSB). Specific binding (SB) was calculated by subtracting NSB from TB. Fitting the SB curve to a one-site receptor binding model, the estimated K D = 1.8 × 10 –9 mol/L and B max = 47.44 fmole, corresponding to 1.1 × 10 5 EGFR/cell

    Journal: EJNMMI Radiopharmacy and Chemistry

    Article Title: Auger electron-emitting EGFR-targeted and non-targeted [ 197 Hg]Hg-gold nanoparticles for treatment of glioblastoma multiforme (GBM)

    doi: 10.1186/s41181-025-00367-2

    Figure Lengend Snippet: Binding of increasing concentrations of panitumumab-[ 197 Hg]Hg-AuNPs to U251-Luc cells in the absence (total binding; TB) or presence of an excess of panitumumab (non-specific binding; NSB). Specific binding (SB) was calculated by subtracting NSB from TB. Fitting the SB curve to a one-site receptor binding model, the estimated K D = 1.8 × 10 –9 mol/L and B max = 47.44 fmole, corresponding to 1.1 × 10 5 EGFR/cell

    Article Snippet: To maximize the potency of the AE emitted by 197 Hg, we further conjugated these [ 197 Hg]Hg-AuNPs to the anti-epidermal growth factor receptor (EGFR) monoclonal antibody, panitumumab (Vectibix®, Amgen) which binds and internalizes them into GBM cells.

    Techniques: Binding Assay