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Short-term (1 year) and long-term (3 years) dyskinesia outcomes, other motor outcomes, quality of life, neuropsychological outcomes, and cognitive functions of the included patients (n = 84) with Parkinson’s disease (PD) and levodopa-induced dyskinesia (LID) who underwent subthalamic nucleus deep brain stimulation (STN-DBS). ( A ) Dyskinesia outcomes such as UDysRS ( A-i ), time spent with LID (MDS-UPDRS-4.1), hours ( A-ii ), and functional impact of LID (MDS-UPDRS-4.2; A-iii ); ( B ) Other motor outcomes such as MDS-UPDRS-III (off-medicine; ( B-i )), MDS-UPDRS-III (on-medicine; ( B-ii )), MDS-UPDRS-II (daily living, ( B-iii )), MDS-UPDRS-IV (motor complications; ( B-iv) ), Hoehn & Yahr (off-medicine; ( B-v )), and LEDD, mg ( B-vi ); ( C ) Quality of life as PDQ-39; ( D ) Neuropsychological outcomes such as MDS-UPDRS-I (nonmotor experiences; ( D-i ), HAM-A ( D-ii ), and HAM-D ( D-iii ); and ( E ) Cognitive function as CMMS ( E-i ) and MoCA ( E-ii ). * P < 0.05 (one-way repeated-measures ANOVA, with post hoc pairwise comparisons adjusted by Bonferroni correction); ** P < 0.01 (one-way repeated-measures ANOVA, with post hoc pairwise comparisons adjusted by Bonferroni correction).

Journal: Clinical Interventions in Aging

Article Title: Long-Term Surgical Outcomes and Influential Factors of Subthalamic Nucleus Deep Brain Stimulation for Dyskinesia in Parkinson’s Disease: A 3-Year Longitudinal Cohort Study

doi: 10.2147/CIA.S600031

Figure Lengend Snippet: Short-term (1 year) and long-term (3 years) dyskinesia outcomes, other motor outcomes, quality of life, neuropsychological outcomes, and cognitive functions of the included patients (n = 84) with Parkinson’s disease (PD) and levodopa-induced dyskinesia (LID) who underwent subthalamic nucleus deep brain stimulation (STN-DBS). ( A ) Dyskinesia outcomes such as UDysRS ( A-i ), time spent with LID (MDS-UPDRS-4.1), hours ( A-ii ), and functional impact of LID (MDS-UPDRS-4.2; A-iii ); ( B ) Other motor outcomes such as MDS-UPDRS-III (off-medicine; ( B-i )), MDS-UPDRS-III (on-medicine; ( B-ii )), MDS-UPDRS-II (daily living, ( B-iii )), MDS-UPDRS-IV (motor complications; ( B-iv) ), Hoehn & Yahr (off-medicine; ( B-v )), and LEDD, mg ( B-vi ); ( C ) Quality of life as PDQ-39; ( D ) Neuropsychological outcomes such as MDS-UPDRS-I (nonmotor experiences; ( D-i ), HAM-A ( D-ii ), and HAM-D ( D-iii ); and ( E ) Cognitive function as CMMS ( E-i ) and MoCA ( E-ii ). * P < 0.05 (one-way repeated-measures ANOVA, with post hoc pairwise comparisons adjusted by Bonferroni correction); ** P < 0.01 (one-way repeated-measures ANOVA, with post hoc pairwise comparisons adjusted by Bonferroni correction).

Article Snippet: The flowchart details the selection process for a study on Parkinson's patients with levodopa-induced dyskinesia who received subthalamic nucleus deep brain stimulation at Beijing Tiantan Hospital.

Techniques: Functional Assay

Relative changes (%) from baseline to short (1 year) term, baseline to long (3 years) term, and short (1 year) term to long (3 years) term dyskinesia outcomes; other motor outcomes; quality of life; neuropsychological outcomes; and cognitive functions of the included patients (n = 84) with Parkinson’s disease (PD) and levodopa-induced dyskinesia (LID) who underwent subthalamic nucleus deep brain stimulation (STN-DBS). ( A ) Dyskinesia outcomes such as UDysRS ( A-i ), time spent with LID (MDS-UPDRS-4.1), hours ( A-ii ), and functional impact of LID (MDS-UPDRS-4.2; ( A-iii) ); ( B ) Other motor outcomes such as MDS-UPDRS-III (off-medicine; ( B-i )), MDS-UPDRS-III (on-medicine; ( B-ii )), MDS-UPDRS-II (daily living, ( B-iii )), MDS-UPDRS-IV (motor complications; ( B-iv )), Hoehn & Yahr (off-medicine; ( B-v )), and LEDD, mg ( B-vi ); ( C ) Quality of life as PDQ-39; ( D ) Neuropsychological outcomes such as MDS-UPDRS-I (nonmotor experiences; ( D-i )), HAM-A ( D-ii ), and HAM-D ( D-iii ); and ( E ) Cognitive function as CMMS ( E-i ) and MoCA ( E-ii ). * P < 0.05 (one-way repeated-measures ANOVA or Friedman test, as appropriate, with post hoc pairwise comparisons adjusted by Bonferroni correction); ** P < 0.01 (one-way repeated-measures ANOVA or Friedman test, as appropriate, with post hoc pairwise comparisons adjusted by Bonferroni correction).

Journal: Clinical Interventions in Aging

Article Title: Long-Term Surgical Outcomes and Influential Factors of Subthalamic Nucleus Deep Brain Stimulation for Dyskinesia in Parkinson’s Disease: A 3-Year Longitudinal Cohort Study

doi: 10.2147/CIA.S600031

Figure Lengend Snippet: Relative changes (%) from baseline to short (1 year) term, baseline to long (3 years) term, and short (1 year) term to long (3 years) term dyskinesia outcomes; other motor outcomes; quality of life; neuropsychological outcomes; and cognitive functions of the included patients (n = 84) with Parkinson’s disease (PD) and levodopa-induced dyskinesia (LID) who underwent subthalamic nucleus deep brain stimulation (STN-DBS). ( A ) Dyskinesia outcomes such as UDysRS ( A-i ), time spent with LID (MDS-UPDRS-4.1), hours ( A-ii ), and functional impact of LID (MDS-UPDRS-4.2; ( A-iii) ); ( B ) Other motor outcomes such as MDS-UPDRS-III (off-medicine; ( B-i )), MDS-UPDRS-III (on-medicine; ( B-ii )), MDS-UPDRS-II (daily living, ( B-iii )), MDS-UPDRS-IV (motor complications; ( B-iv )), Hoehn & Yahr (off-medicine; ( B-v )), and LEDD, mg ( B-vi ); ( C ) Quality of life as PDQ-39; ( D ) Neuropsychological outcomes such as MDS-UPDRS-I (nonmotor experiences; ( D-i )), HAM-A ( D-ii ), and HAM-D ( D-iii ); and ( E ) Cognitive function as CMMS ( E-i ) and MoCA ( E-ii ). * P < 0.05 (one-way repeated-measures ANOVA or Friedman test, as appropriate, with post hoc pairwise comparisons adjusted by Bonferroni correction); ** P < 0.01 (one-way repeated-measures ANOVA or Friedman test, as appropriate, with post hoc pairwise comparisons adjusted by Bonferroni correction).

Article Snippet: The flowchart details the selection process for a study on Parkinson's patients with levodopa-induced dyskinesia who received subthalamic nucleus deep brain stimulation at Beijing Tiantan Hospital.

Techniques: Functional Assay