Review



rn1734  (Tocris)


Bioz Verified Symbol Tocris is a verified supplier
Bioz Manufacturer Symbol Tocris manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 94
      Buy from Supplier

    Structured Review

    Tocris rn1734
    A. Setup for recording L4-evoked postsynaptic potential and spiking in an excitatory pyramidal neuron (PN) with an intracellular blocker of TRPV3 channels (Forsythoside B, 50 µM) (left) or <t>TRPV4</t> channels <t>(RN1734,</t> 10 µM) (right) at just-subthreshold V m at 30°C, 36°C, and 39°C in mouse S1 cortex. B. Percentages of cell types obtained from experiment in A. C. Evoked spikes in L2/3 PNs during temperature elevations to 30°C, 36°C, and 39°C with TRPV3 (Forsythoside B, 50 µM) or TRPV4 (RN1734, 10 µM) blockers. D. Correlation of PSP peak versus spike threshold (ST). r = Pearson correlation coefficient with Deming linear regression. E. Same as (C) for the L4-evoked late PSP peak. F. Same as (C) for input resistance. Each data point represents an individual cell in C, E and F. Data collected from 26 cells in 7 animals for TRPV3 blocker, 24 cells in 6 animals for TRPV4 blocker, and 37 cells from 14 animals for no block condition. Mean with standard error mean is indicated in C, E and F. Significance assessed by one- and two-way repeated measures ANOVA with Tukey’s or Sidak post-hoc test at α=0.05.
    Rn1734, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 69 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rn1734/product/Tocris
    Average 94 stars, based on 69 article reviews
    rn1734 - by Bioz Stars, 2026-02
    94/100 stars

    Images

    1) Product Images from "TRPV3 channel activity helps cortical neurons stay active during fever"

    Article Title: TRPV3 channel activity helps cortical neurons stay active during fever

    Journal: bioRxiv

    doi: 10.1101/2024.09.09.612112

    A. Setup for recording L4-evoked postsynaptic potential and spiking in an excitatory pyramidal neuron (PN) with an intracellular blocker of TRPV3 channels (Forsythoside B, 50 µM) (left) or TRPV4 channels (RN1734, 10 µM) (right) at just-subthreshold V m at 30°C, 36°C, and 39°C in mouse S1 cortex. B. Percentages of cell types obtained from experiment in A. C. Evoked spikes in L2/3 PNs during temperature elevations to 30°C, 36°C, and 39°C with TRPV3 (Forsythoside B, 50 µM) or TRPV4 (RN1734, 10 µM) blockers. D. Correlation of PSP peak versus spike threshold (ST). r = Pearson correlation coefficient with Deming linear regression. E. Same as (C) for the L4-evoked late PSP peak. F. Same as (C) for input resistance. Each data point represents an individual cell in C, E and F. Data collected from 26 cells in 7 animals for TRPV3 blocker, 24 cells in 6 animals for TRPV4 blocker, and 37 cells from 14 animals for no block condition. Mean with standard error mean is indicated in C, E and F. Significance assessed by one- and two-way repeated measures ANOVA with Tukey’s or Sidak post-hoc test at α=0.05.
    Figure Legend Snippet: A. Setup for recording L4-evoked postsynaptic potential and spiking in an excitatory pyramidal neuron (PN) with an intracellular blocker of TRPV3 channels (Forsythoside B, 50 µM) (left) or TRPV4 channels (RN1734, 10 µM) (right) at just-subthreshold V m at 30°C, 36°C, and 39°C in mouse S1 cortex. B. Percentages of cell types obtained from experiment in A. C. Evoked spikes in L2/3 PNs during temperature elevations to 30°C, 36°C, and 39°C with TRPV3 (Forsythoside B, 50 µM) or TRPV4 (RN1734, 10 µM) blockers. D. Correlation of PSP peak versus spike threshold (ST). r = Pearson correlation coefficient with Deming linear regression. E. Same as (C) for the L4-evoked late PSP peak. F. Same as (C) for input resistance. Each data point represents an individual cell in C, E and F. Data collected from 26 cells in 7 animals for TRPV3 blocker, 24 cells in 6 animals for TRPV4 blocker, and 37 cells from 14 animals for no block condition. Mean with standard error mean is indicated in C, E and F. Significance assessed by one- and two-way repeated measures ANOVA with Tukey’s or Sidak post-hoc test at α=0.05.

    Techniques Used: Blocking Assay



    Similar Products

    rn1734  (Tocris)
    94
    Tocris rn1734
    A. Setup for recording L4-evoked postsynaptic potential and spiking in an excitatory pyramidal neuron (PN) with an intracellular blocker of TRPV3 channels (Forsythoside B, 50 µM) (left) or <t>TRPV4</t> channels <t>(RN1734,</t> 10 µM) (right) at just-subthreshold V m at 30°C, 36°C, and 39°C in mouse S1 cortex. B. Percentages of cell types obtained from experiment in A. C. Evoked spikes in L2/3 PNs during temperature elevations to 30°C, 36°C, and 39°C with TRPV3 (Forsythoside B, 50 µM) or TRPV4 (RN1734, 10 µM) blockers. D. Correlation of PSP peak versus spike threshold (ST). r = Pearson correlation coefficient with Deming linear regression. E. Same as (C) for the L4-evoked late PSP peak. F. Same as (C) for input resistance. Each data point represents an individual cell in C, E and F. Data collected from 26 cells in 7 animals for TRPV3 blocker, 24 cells in 6 animals for TRPV4 blocker, and 37 cells from 14 animals for no block condition. Mean with standard error mean is indicated in C, E and F. Significance assessed by one- and two-way repeated measures ANOVA with Tukey’s or Sidak post-hoc test at α=0.05.
    Rn1734, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rn1734/product/Tocris
    Average 94 stars, based on 1 article reviews
    rn1734 - by Bioz Stars, 2026-02
    94/100 stars
    		  Buy from Supplier
    rn1734  (MedChemExpress)
    93
    MedChemExpress rn1734
    A. Setup for recording L4-evoked postsynaptic potential and spiking in an excitatory pyramidal neuron (PN) with an intracellular blocker of TRPV3 channels (Forsythoside B, 50 µM) (left) or <t>TRPV4</t> channels <t>(RN1734,</t> 10 µM) (right) at just-subthreshold V m at 30°C, 36°C, and 39°C in mouse S1 cortex. B. Percentages of cell types obtained from experiment in A. C. Evoked spikes in L2/3 PNs during temperature elevations to 30°C, 36°C, and 39°C with TRPV3 (Forsythoside B, 50 µM) or TRPV4 (RN1734, 10 µM) blockers. D. Correlation of PSP peak versus spike threshold (ST). r = Pearson correlation coefficient with Deming linear regression. E. Same as (C) for the L4-evoked late PSP peak. F. Same as (C) for input resistance. Each data point represents an individual cell in C, E and F. Data collected from 26 cells in 7 animals for TRPV3 blocker, 24 cells in 6 animals for TRPV4 blocker, and 37 cells from 14 animals for no block condition. Mean with standard error mean is indicated in C, E and F. Significance assessed by one- and two-way repeated measures ANOVA with Tukey’s or Sidak post-hoc test at α=0.05.
    Rn1734, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rn1734/product/MedChemExpress
    Average 93 stars, based on 1 article reviews
    rn1734 - by Bioz Stars, 2026-02
    93/100 stars
    		  Buy from Supplier
    rn1734  (Dawley Inc)
    90
    Dawley Inc rn1734
    A. Setup for recording L4-evoked postsynaptic potential and spiking in an excitatory pyramidal neuron (PN) with an intracellular blocker of TRPV3 channels (Forsythoside B, 50 µM) (left) or <t>TRPV4</t> channels <t>(RN1734,</t> 10 µM) (right) at just-subthreshold V m at 30°C, 36°C, and 39°C in mouse S1 cortex. B. Percentages of cell types obtained from experiment in A. C. Evoked spikes in L2/3 PNs during temperature elevations to 30°C, 36°C, and 39°C with TRPV3 (Forsythoside B, 50 µM) or TRPV4 (RN1734, 10 µM) blockers. D. Correlation of PSP peak versus spike threshold (ST). r = Pearson correlation coefficient with Deming linear regression. E. Same as (C) for the L4-evoked late PSP peak. F. Same as (C) for input resistance. Each data point represents an individual cell in C, E and F. Data collected from 26 cells in 7 animals for TRPV3 blocker, 24 cells in 6 animals for TRPV4 blocker, and 37 cells from 14 animals for no block condition. Mean with standard error mean is indicated in C, E and F. Significance assessed by one- and two-way repeated measures ANOVA with Tukey’s or Sidak post-hoc test at α=0.05.
    Rn1734, supplied by Dawley Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rn1734/product/Dawley Inc
    Average 90 stars, based on 1 article reviews
    rn1734 - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    rn-1734 rn1734  (Millipore)
    90
    Millipore rn-1734 rn1734
    A. Setup for recording L4-evoked postsynaptic potential and spiking in an excitatory pyramidal neuron (PN) with an intracellular blocker of TRPV3 channels (Forsythoside B, 50 µM) (left) or <t>TRPV4</t> channels <t>(RN1734,</t> 10 µM) (right) at just-subthreshold V m at 30°C, 36°C, and 39°C in mouse S1 cortex. B. Percentages of cell types obtained from experiment in A. C. Evoked spikes in L2/3 PNs during temperature elevations to 30°C, 36°C, and 39°C with TRPV3 (Forsythoside B, 50 µM) or TRPV4 (RN1734, 10 µM) blockers. D. Correlation of PSP peak versus spike threshold (ST). r = Pearson correlation coefficient with Deming linear regression. E. Same as (C) for the L4-evoked late PSP peak. F. Same as (C) for input resistance. Each data point represents an individual cell in C, E and F. Data collected from 26 cells in 7 animals for TRPV3 blocker, 24 cells in 6 animals for TRPV4 blocker, and 37 cells from 14 animals for no block condition. Mean with standard error mean is indicated in C, E and F. Significance assessed by one- and two-way repeated measures ANOVA with Tukey’s or Sidak post-hoc test at α=0.05.
    Rn 1734 Rn1734, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rn-1734 rn1734/product/Millipore
    Average 90 stars, based on 1 article reviews
    rn-1734 rn1734 - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    rn1734 (rn)  (Millipore)
    90
    Millipore rn1734 (rn)
    A. Setup for recording L4-evoked postsynaptic potential and spiking in an excitatory pyramidal neuron (PN) with an intracellular blocker of TRPV3 channels (Forsythoside B, 50 µM) (left) or <t>TRPV4</t> channels <t>(RN1734,</t> 10 µM) (right) at just-subthreshold V m at 30°C, 36°C, and 39°C in mouse S1 cortex. B. Percentages of cell types obtained from experiment in A. C. Evoked spikes in L2/3 PNs during temperature elevations to 30°C, 36°C, and 39°C with TRPV3 (Forsythoside B, 50 µM) or TRPV4 (RN1734, 10 µM) blockers. D. Correlation of PSP peak versus spike threshold (ST). r = Pearson correlation coefficient with Deming linear regression. E. Same as (C) for the L4-evoked late PSP peak. F. Same as (C) for input resistance. Each data point represents an individual cell in C, E and F. Data collected from 26 cells in 7 animals for TRPV3 blocker, 24 cells in 6 animals for TRPV4 blocker, and 37 cells from 14 animals for no block condition. Mean with standard error mean is indicated in C, E and F. Significance assessed by one- and two-way repeated measures ANOVA with Tukey’s or Sidak post-hoc test at α=0.05.
    Rn1734 (Rn), supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rn1734 (rn)/product/Millipore
    Average 90 stars, based on 1 article reviews
    rn1734 (rn) - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    A. Setup for recording L4-evoked postsynaptic potential and spiking in an excitatory pyramidal neuron (PN) with an intracellular blocker of TRPV3 channels (Forsythoside B, 50 µM) (left) or TRPV4 channels (RN1734, 10 µM) (right) at just-subthreshold V m at 30°C, 36°C, and 39°C in mouse S1 cortex. B. Percentages of cell types obtained from experiment in A. C. Evoked spikes in L2/3 PNs during temperature elevations to 30°C, 36°C, and 39°C with TRPV3 (Forsythoside B, 50 µM) or TRPV4 (RN1734, 10 µM) blockers. D. Correlation of PSP peak versus spike threshold (ST). r = Pearson correlation coefficient with Deming linear regression. E. Same as (C) for the L4-evoked late PSP peak. F. Same as (C) for input resistance. Each data point represents an individual cell in C, E and F. Data collected from 26 cells in 7 animals for TRPV3 blocker, 24 cells in 6 animals for TRPV4 blocker, and 37 cells from 14 animals for no block condition. Mean with standard error mean is indicated in C, E and F. Significance assessed by one- and two-way repeated measures ANOVA with Tukey’s or Sidak post-hoc test at α=0.05.

    Journal: bioRxiv

    Article Title: TRPV3 channel activity helps cortical neurons stay active during fever

    doi: 10.1101/2024.09.09.612112

    Figure Lengend Snippet: A. Setup for recording L4-evoked postsynaptic potential and spiking in an excitatory pyramidal neuron (PN) with an intracellular blocker of TRPV3 channels (Forsythoside B, 50 µM) (left) or TRPV4 channels (RN1734, 10 µM) (right) at just-subthreshold V m at 30°C, 36°C, and 39°C in mouse S1 cortex. B. Percentages of cell types obtained from experiment in A. C. Evoked spikes in L2/3 PNs during temperature elevations to 30°C, 36°C, and 39°C with TRPV3 (Forsythoside B, 50 µM) or TRPV4 (RN1734, 10 µM) blockers. D. Correlation of PSP peak versus spike threshold (ST). r = Pearson correlation coefficient with Deming linear regression. E. Same as (C) for the L4-evoked late PSP peak. F. Same as (C) for input resistance. Each data point represents an individual cell in C, E and F. Data collected from 26 cells in 7 animals for TRPV3 blocker, 24 cells in 6 animals for TRPV4 blocker, and 37 cells from 14 animals for no block condition. Mean with standard error mean is indicated in C, E and F. Significance assessed by one- and two-way repeated measures ANOVA with Tukey’s or Sidak post-hoc test at α=0.05.

    Article Snippet: Where applicable, forsythoside B (50 µM, TRPV3 blocker, Millipore Sigma Cat #: PHL83313) or RN1734 (10 µM, TRPV4 blocker , Tocris Bioscience Cat #: 3746/25) was added to the internal solution.

    Techniques: Blocking Assay