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Metabolite profiling in PXB-mouse blood and urine, human and mouse hepatocytes, and in human plasma and urine.

Journal: International Journal of Molecular Sciences

Article Title: Investigation of Biotransformation Pathways in a Chimeric Mouse with a Humanized Liver

doi: 10.3390/ijms26031141

Figure Lengend Snippet: Metabolite profiling in PXB-mouse blood and urine, human and mouse hepatocytes, and in human plasma and urine.

Article Snippet: Cerivastatin (IUPAC: (3R,5S,6E)-7-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid), glipizide (IUPAC: N-(4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl)-5-methylpyrazine-2-carboxamide)), repaglinide (IUPAC: (S)-2-ethoxy-4-(2-((3-methyl-1-(2-(piperidin-1-yl) phenyl)butyl)amino)-2-oxoethyl)benzoic acid) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD)), pitavastatin (IUPAC: (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid), telmisartan (IUPAC: 2-(4-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic acid), and tesaglitazar (IUPAC: (2S)-2-ethoxy-3-[4-(2-{4-[(methylsulfonyl)oxy]phenyl}ethoxy)phenyl]propanoic acid) was obtained from SigmaAldrich (Schnelldorf, Germany).

Techniques: Clinical Proteomics, Transformation Assay, Conjugation Assay

Human plasma metabolites detected in PXB-mouse blood, and in human and mouse hepatocytes.

Journal: International Journal of Molecular Sciences

Article Title: Investigation of Biotransformation Pathways in a Chimeric Mouse with a Humanized Liver

doi: 10.3390/ijms26031141

Figure Lengend Snippet: Human plasma metabolites detected in PXB-mouse blood, and in human and mouse hepatocytes.

Article Snippet: Cerivastatin (IUPAC: (3R,5S,6E)-7-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid), glipizide (IUPAC: N-(4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl)-5-methylpyrazine-2-carboxamide)), repaglinide (IUPAC: (S)-2-ethoxy-4-(2-((3-methyl-1-(2-(piperidin-1-yl) phenyl)butyl)amino)-2-oxoethyl)benzoic acid) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD)), pitavastatin (IUPAC: (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid), telmisartan (IUPAC: 2-(4-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic acid), and tesaglitazar (IUPAC: (2S)-2-ethoxy-3-[4-(2-{4-[(methylsulfonyl)oxy]phenyl}ethoxy)phenyl]propanoic acid) was obtained from SigmaAldrich (Schnelldorf, Germany).

Techniques: Clinical Proteomics

Human urine metabolites detected in PXB-mouse blood, and in human and mouse hepatocytes.

Journal: International Journal of Molecular Sciences

Article Title: Investigation of Biotransformation Pathways in a Chimeric Mouse with a Humanized Liver

doi: 10.3390/ijms26031141

Figure Lengend Snippet: Human urine metabolites detected in PXB-mouse blood, and in human and mouse hepatocytes.

Article Snippet: Cerivastatin (IUPAC: (3R,5S,6E)-7-[4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid), glipizide (IUPAC: N-(4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl)-5-methylpyrazine-2-carboxamide)), repaglinide (IUPAC: (S)-2-ethoxy-4-(2-((3-methyl-1-(2-(piperidin-1-yl) phenyl)butyl)amino)-2-oxoethyl)benzoic acid) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD)), pitavastatin (IUPAC: (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid), telmisartan (IUPAC: 2-(4-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic acid), and tesaglitazar (IUPAC: (2S)-2-ethoxy-3-[4-(2-{4-[(methylsulfonyl)oxy]phenyl}ethoxy)phenyl]propanoic acid) was obtained from SigmaAldrich (Schnelldorf, Germany).

Techniques: