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Image Search Results
Journal: Scientific Reports
Article Title: Inosine attenuates spontaneous activity in the rat neurogenic bladder through an A 2B pathway
doi: 10.1038/srep44416
Figure Lengend Snippet: ( A , B ) The attenuation of SA by inosine was reversed by the large conductance Ca 2+ -activated potassium channel blocker iberiotoxin (IBTX, 100 nM, n = 7). The SK3 channel blocker apamin (100 nM, n = 7) and the K ATP channel blocker repaglinide (10 μM, n = 8) did not prevent the attenuation of SA induced by inosine (**p < 0.01, **p < 0.001, Baseline versus Ino; *p < 0.05, Apamin versus Apamin + Ino, Regap versus Repag + Ino). ( C ) The attenuation of SA by the A 2B agonist BAY60-6583 (100 μM) was blocked by IBTX (100 nM, n = 5). Data are expressed as mean ± SEM, but with values normalised to drug alone, as opposed to baseline, as described in Methods.
Article Snippet: Reagents were purchased from suppliers as indicated: Inosine (Sigma-Aldrich, St. Louis, MO); CGS15943, MRS3777, PSB36, PSB603, ZM241385, PSB0777, NECA, BAY60-6583,
Techniques: