Journal: iScience
Article Title: Distinct transcriptomic signatures in pulmonary tissue resident and vascular resident-like T cells in nonhuman primates
doi: 10.1016/j.isci.2025.112745
Figure Lengend Snippet: Pathway enrichment analysis (PEA) suggests ivs+ CD8 + T cells have an enhanced ability to interact with endothelial cells (A) Tree plot illustrating significantly enriched pathways in lung ivs+ CD8 + T cells. Hierarchical clustering of enriched terms based on Jaccard’s similarity index (JC). (B and C) Gene-concept network plots depicting genes (blue dots) involved in enriched terms (red dots) associated with signaling events (B) and vascular interactions (C). (D) Reactome “cell surface interactions at the vascular cell wall” pathway associated genes upregulated or downregulated in lung ivs+ CD8 + T cells. For PEA an adj p value (FDR) ≤ 0.05 was used to determine significance. See also and .
Article Snippet: We performed PEA using the Reactome gene collection from The Broad Institute Molecular Signature Database (MSigDB), , which was filtered to contain only genes present in our dataset in order to avoid bias.
Techniques: