rapa (MedChemExpress)
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rapa
Rapa, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1252 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rapa/Rapamycin/pmc12963995-286-0-5
Average 99 stars, based on 1252 article reviews
Rapa, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1252 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rapa/Rapamycin/pmc12963995-286-0-5
Average 99 stars, based on 1252 article reviews
rapa - by Bioz Stars,
2026-09
99/100 stars
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Expressing:Article Title: FASN mediates crosstalk between autophagy and lipid metabolism via the AMPK-MTOR pathway in early age-related macular degeneration. Article Snippet: Age-related macular degeneration (AMD) involves sub-retinal pigment epithelium (sub-RPE) lipid deposition in the early stage, with dysregulated lipid metabolism and impaired macroautophagy/ autophagy implicated, yet the molecular mechanisms underlying their interaction remain unclear.. In this study, transcriptomic analysis of human macular tissues identified FASN (fatty acid synthase), a regulator of lipid metabolism and lysosomal function, as a significantly upregulated key hub gene in early AMD.. In apoe mice fed a high-fat diet (HFD), retina-RPE-choroid complexes revealed elevated FASN alongside autophagy suppression, lysosomal dysfunction, and lipid accumulation. Transfection:Article Title: FASN mediates crosstalk between autophagy and lipid metabolism via the AMPK-MTOR pathway in early age-related macular degeneration. Article Snippet: Age-related macular degeneration (AMD) involves sub-retinal pigment epithelium (sub-RPE) lipid deposition in the early stage, with dysregulated lipid metabolism and impaired macroautophagy/ autophagy implicated, yet the molecular mechanisms underlying their interaction remain unclear.. In this study, transcriptomic analysis of human macular tissues identified FASN (fatty acid synthase), a regulator of lipid metabolism and lysosomal function, as a significantly upregulated key hub gene in early AMD.. In apoe mice fed a high-fat diet (HFD), retina-RPE-choroid complexes revealed elevated FASN alongside autophagy suppression, lysosomal dysfunction, and lipid accumulation. Article Title: A compact and inducible dCas12f-based CRISPRa platform for programmable in vivo gene activation Article Snippet: To evaluate chemically controlled endogenous gene activation, 8 × 10 4 cells were plated in a 24-well plate and co-transfected with plasmids encoding the ChemHEAL system targeting the corresponding gene [pWH299 (P hCMV -2 × c-MYC NLS-dUn1Cas12f (D143R/T147R/K330R)−1 × c-MYC NLS-pA), pWH253 (P hCMV -PYL1-MCP-pA), pWH255 (P hCMV -ABI-p65-HSF1-pA), pWH260 (P hCMV -GNCR1-MCP-pA), pWH261 (P hCMV -NS3a-MCP-pA), pWH265 (P hCMV -NS3a-p65-HSF1-pA), pDQ601 (P hCMV -MCP-FKBP-pA), pDQ603 (P hCMV -p65-HSF1-FRB-pA), pDQ610 (P hCMV -DNCR2-p65-HSF1-pA), and sgRNAs targeting the corresponding gene]. .. Twenty-four hours after transfection, the culture medium was refreshed, and the cells were incubated with ABA (100 μM; Sigma-Aldrich, 90769), GZV (10 μM; Adooq Bioscience, A173303), DNV (10 μM; Adooq Bioscience, RG7227), or Construct:Article Title: FASN mediates crosstalk between autophagy and lipid metabolism via the AMPK-MTOR pathway in early age-related macular degeneration. Article Snippet: Age-related macular degeneration (AMD) involves sub-retinal pigment epithelium (sub-RPE) lipid deposition in the early stage, with dysregulated lipid metabolism and impaired macroautophagy/ autophagy implicated, yet the molecular mechanisms underlying their interaction remain unclear.. In this study, transcriptomic analysis of human macular tissues identified FASN (fatty acid synthase), a regulator of lipid metabolism and lysosomal function, as a significantly upregulated key hub gene in early AMD.. In apoe mice fed a high-fat diet (HFD), retina-RPE-choroid complexes revealed elevated FASN alongside autophagy suppression, lysosomal dysfunction, and lipid accumulation. Infection:Article Title: FASN mediates crosstalk between autophagy and lipid metabolism via the AMPK-MTOR pathway in early age-related macular degeneration. Article Snippet: Age-related macular degeneration (AMD) involves sub-retinal pigment epithelium (sub-RPE) lipid deposition in the early stage, with dysregulated lipid metabolism and impaired macroautophagy/ autophagy implicated, yet the molecular mechanisms underlying their interaction remain unclear.. In this study, transcriptomic analysis of human macular tissues identified FASN (fatty acid synthase), a regulator of lipid metabolism and lysosomal function, as a significantly upregulated key hub gene in early AMD.. In apoe mice fed a high-fat diet (HFD), retina-RPE-choroid complexes revealed elevated FASN alongside autophagy suppression, lysosomal dysfunction, and lipid accumulation. Control:Article Title: FASN mediates crosstalk between autophagy and lipid metabolism via the AMPK-MTOR pathway in early age-related macular degeneration. Article Snippet: Age-related macular degeneration (AMD) involves sub-retinal pigment epithelium (sub-RPE) lipid deposition in the early stage, with dysregulated lipid metabolism and impaired macroautophagy/ autophagy implicated, yet the molecular mechanisms underlying their interaction remain unclear.. In this study, transcriptomic analysis of human macular tissues identified FASN (fatty acid synthase), a regulator of lipid metabolism and lysosomal function, as a significantly upregulated key hub gene in early AMD.. In apoe mice fed a high-fat diet (HFD), retina-RPE-choroid complexes revealed elevated FASN alongside autophagy suppression, lysosomal dysfunction, and lipid accumulation. Incubation:Article Title: A compact and inducible dCas12f-based CRISPRa platform for programmable in vivo gene activation Article Snippet: To evaluate chemically controlled endogenous gene activation, 8 × 10 4 cells were plated in a 24-well plate and co-transfected with plasmids encoding the ChemHEAL system targeting the corresponding gene [pWH299 (P hCMV -2 × c-MYC NLS-dUn1Cas12f (D143R/T147R/K330R)−1 × c-MYC NLS-pA), pWH253 (P hCMV -PYL1-MCP-pA), pWH255 (P hCMV -ABI-p65-HSF1-pA), pWH260 (P hCMV -GNCR1-MCP-pA), pWH261 (P hCMV -NS3a-MCP-pA), pWH265 (P hCMV -NS3a-p65-HSF1-pA), pDQ601 (P hCMV -MCP-FKBP-pA), pDQ603 (P hCMV -p65-HSF1-FRB-pA), pDQ610 (P hCMV -DNCR2-p65-HSF1-pA), and sgRNAs targeting the corresponding gene]. .. Twenty-four hours after transfection, the culture medium was refreshed, and the cells were incubated with ABA (100 μM; Sigma-Aldrich, 90769), GZV (10 μM; Adooq Bioscience, A173303), DNV (10 μM; Adooq Bioscience, RG7227), or Article Title: The optineurin fatty acid-binding protein 3 axis: A novel regulator of autophagy and apoptosis in myocardial infarction. Article Snippet: Background: Autophagy and apoptosis co-regulate the fate of cardiomyocytes after myocardial infarction (MI).. OPTN is a well-characterized autophagy inducer, while FABP3 promotes apoptosis.. However, the functional interaction between the two in MI remained unclear. other:Article Title: A multimodal ROS logic-gated therapeutic platform disrupts the vicious cycle of senescence to promote aged bone defect repair Article Snippet: Article Title: OSBPL10 alleviates neuronal ferroptosis via lysosomal membrane repair in a PS-dependent manner after spinal cord injury Article Snippet: Cell Culture:Article Title: The optineurin fatty acid-binding protein 3 axis: A novel regulator of autophagy and apoptosis in myocardial infarction. Article Snippet: Background: Autophagy and apoptosis co-regulate the fate of cardiomyocytes after myocardial infarction (MI).. OPTN is a well-characterized autophagy inducer, while FABP3 promotes apoptosis.. However, the functional interaction between the two in MI remained unclear. Inhibition:Article Title: The optineurin fatty acid-binding protein 3 axis: A novel regulator of autophagy and apoptosis in myocardial infarction. Article Snippet: Background: Autophagy and apoptosis co-regulate the fate of cardiomyocytes after myocardial infarction (MI).. OPTN is a well-characterized autophagy inducer, while FABP3 promotes apoptosis.. However, the functional interaction between the two in MI remained unclear. Activation Assay:Article Title: The optineurin fatty acid-binding protein 3 axis: A novel regulator of autophagy and apoptosis in myocardial infarction. Article Snippet: Background: Autophagy and apoptosis co-regulate the fate of cardiomyocytes after myocardial infarction (MI).. OPTN is a well-characterized autophagy inducer, while FABP3 promotes apoptosis.. However, the functional interaction between the two in MI remained unclear. |