Journal: Infection and Drug Resistance
Article Title: Comparative in vitro Activity and Clinical Outcomes of Eravacycline, Tigecycline, and Omadacycline Against Carbapenem-Resistant Acinetobacter baumannii and Klebsiella pneumoniae
doi: 10.2147/IDR.S583973
Figure Lengend Snippet: Time-kill Curves for Eravacycline, Tigecycline, and Omadacycline against CRKP and CRAB. ( a ) Eravacycline susceptibility of CRKP and CRAB strains with diverse resistance phenotypes. ( b ) Comparison of eravacycline, tigecycline, and omadacycline against CRKP. ( c ) Comparison of the three tetracyclines against CRAB. K. pneumoniae ATCC BAA-1705 and A. baumannii ATCC 19606 served as positive growth controls for CRKP and CRAB, respectively. The time-kill assays were performed at concentrations corresponding to the MIC 90 values determined for the clinical isolates: 1/4/32 mg/L (ERV/TGC/OMC) for CRKP and 0.25/1/2 mg/L (ERV/TGC/OMC) for CRAB. Bactericidal activity was defined as a ≥ 3-log 10 CFU/mL reduction under the tested conditions (initial inoculum: 10 5 CFU/mL; temperature: 37°C).
Article Snippet: Reference strains included KPC-producing K. pneumoniae ATCC BAA-1705 and OXA-23-producing A. baumannii ATCC 19606.
Techniques: Comparison, Activity Assay