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pf1022a  (MedChemExpress)


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    Structured Review

    MedChemExpress pf1022a
    Stimulatory effect of BRV on the activity of the large-conductance Ca 2+ -activated K + (BK Ca ) channels in GH 3 cells. In this set of inside-out current recordings, the cells were immersed in a high-K + solution containing 1 µM Ca 2+ , where the holding potential was clamped at +60 mV. ( A ) Representative BK Ca -channel traces (blue color) obtained in the control (i.e., BRV was not present) (left side of the figure) and after the bath addition of 10 µM of BRV (right side of the figure). It should be noted that the upward deflection shows the channel opening event. The lower part (red color) of the figure shows the expanded records taken from the uppermost part of the figure; ( B ) Summary bar graph showing the open-state likelihood of the presence of BK Ca channels in the presence of BRV (10 µM), BRV (10 µM) plus TRAM39 (3 µM), BRV (10 µM) plus GAL-021 (3 µM), and BRV (10 µM) plus <t>PF1022A</t> (3 µM) (mean ± SEM; n = 7–8). The channel activity was measured when the membrane patch was maintained at +60 mV. * Significantly different from the control ( p < 0.05) and Ɨ significantly different from the 10 µM BRV-alone group ( p < 0.05).
    Pf1022a, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 90 stars, based on 4 article reviews
    pf1022a - by Bioz Stars, 2026-02
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    Images

    1) Product Images from "The Integrated Effects of Brivaracetam, a Selective Analog of Levetiracetam, on Ionic Currents and Neuronal Excitability"

    Article Title: The Integrated Effects of Brivaracetam, a Selective Analog of Levetiracetam, on Ionic Currents and Neuronal Excitability

    Journal: Biomedicines

    doi: 10.3390/biomedicines9040369

    Stimulatory effect of BRV on the activity of the large-conductance Ca 2+ -activated K + (BK Ca ) channels in GH 3 cells. In this set of inside-out current recordings, the cells were immersed in a high-K + solution containing 1 µM Ca 2+ , where the holding potential was clamped at +60 mV. ( A ) Representative BK Ca -channel traces (blue color) obtained in the control (i.e., BRV was not present) (left side of the figure) and after the bath addition of 10 µM of BRV (right side of the figure). It should be noted that the upward deflection shows the channel opening event. The lower part (red color) of the figure shows the expanded records taken from the uppermost part of the figure; ( B ) Summary bar graph showing the open-state likelihood of the presence of BK Ca channels in the presence of BRV (10 µM), BRV (10 µM) plus TRAM39 (3 µM), BRV (10 µM) plus GAL-021 (3 µM), and BRV (10 µM) plus PF1022A (3 µM) (mean ± SEM; n = 7–8). The channel activity was measured when the membrane patch was maintained at +60 mV. * Significantly different from the control ( p < 0.05) and Ɨ significantly different from the 10 µM BRV-alone group ( p < 0.05).
    Figure Legend Snippet: Stimulatory effect of BRV on the activity of the large-conductance Ca 2+ -activated K + (BK Ca ) channels in GH 3 cells. In this set of inside-out current recordings, the cells were immersed in a high-K + solution containing 1 µM Ca 2+ , where the holding potential was clamped at +60 mV. ( A ) Representative BK Ca -channel traces (blue color) obtained in the control (i.e., BRV was not present) (left side of the figure) and after the bath addition of 10 µM of BRV (right side of the figure). It should be noted that the upward deflection shows the channel opening event. The lower part (red color) of the figure shows the expanded records taken from the uppermost part of the figure; ( B ) Summary bar graph showing the open-state likelihood of the presence of BK Ca channels in the presence of BRV (10 µM), BRV (10 µM) plus TRAM39 (3 µM), BRV (10 µM) plus GAL-021 (3 µM), and BRV (10 µM) plus PF1022A (3 µM) (mean ± SEM; n = 7–8). The channel activity was measured when the membrane patch was maintained at +60 mV. * Significantly different from the control ( p < 0.05) and Ɨ significantly different from the 10 µM BRV-alone group ( p < 0.05).

    Techniques Used: Activity Assay, Control, Membrane



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    Image Search Results


    Stimulatory effect of BRV on the activity of the large-conductance Ca 2+ -activated K + (BK Ca ) channels in GH 3 cells. In this set of inside-out current recordings, the cells were immersed in a high-K + solution containing 1 µM Ca 2+ , where the holding potential was clamped at +60 mV. ( A ) Representative BK Ca -channel traces (blue color) obtained in the control (i.e., BRV was not present) (left side of the figure) and after the bath addition of 10 µM of BRV (right side of the figure). It should be noted that the upward deflection shows the channel opening event. The lower part (red color) of the figure shows the expanded records taken from the uppermost part of the figure; ( B ) Summary bar graph showing the open-state likelihood of the presence of BK Ca channels in the presence of BRV (10 µM), BRV (10 µM) plus TRAM39 (3 µM), BRV (10 µM) plus GAL-021 (3 µM), and BRV (10 µM) plus PF1022A (3 µM) (mean ± SEM; n = 7–8). The channel activity was measured when the membrane patch was maintained at +60 mV. * Significantly different from the control ( p < 0.05) and Ɨ significantly different from the 10 µM BRV-alone group ( p < 0.05).

    Journal: Biomedicines

    Article Title: The Integrated Effects of Brivaracetam, a Selective Analog of Levetiracetam, on Ionic Currents and Neuronal Excitability

    doi: 10.3390/biomedicines9040369

    Figure Lengend Snippet: Stimulatory effect of BRV on the activity of the large-conductance Ca 2+ -activated K + (BK Ca ) channels in GH 3 cells. In this set of inside-out current recordings, the cells were immersed in a high-K + solution containing 1 µM Ca 2+ , where the holding potential was clamped at +60 mV. ( A ) Representative BK Ca -channel traces (blue color) obtained in the control (i.e., BRV was not present) (left side of the figure) and after the bath addition of 10 µM of BRV (right side of the figure). It should be noted that the upward deflection shows the channel opening event. The lower part (red color) of the figure shows the expanded records taken from the uppermost part of the figure; ( B ) Summary bar graph showing the open-state likelihood of the presence of BK Ca channels in the presence of BRV (10 µM), BRV (10 µM) plus TRAM39 (3 µM), BRV (10 µM) plus GAL-021 (3 µM), and BRV (10 µM) plus PF1022A (3 µM) (mean ± SEM; n = 7–8). The channel activity was measured when the membrane patch was maintained at +60 mV. * Significantly different from the control ( p < 0.05) and Ɨ significantly different from the 10 µM BRV-alone group ( p < 0.05).

    Article Snippet: GAL-021 and PF1022A were acquired from MedChemExpress (Everything Biotech, New Taipei City, Taiwan); cilobradine was obtained from Cayman (Excel Biomedical, Taipei, Taiwan); 2-chloro-α, α-diphenylbenzeneacetonitrile (TRAM39) was obtained from Tocris (Union Biomed Inc., Taipei, Taiwan), and tefluthrhin, tetraethylammonium chloride and tetrodotoxin were obtained from Sigma-Aldrich (Merck Ltd., Taipei, Taiwan).

    Techniques: Activity Assay, Control, Membrane

    Chemical structures of the semisynthetic emodepside (A) and its precursor PF1022A (B) purified from Rosellinia spp. PF1022.

    Journal: PLoS Pathogens

    Article Title: Development of emodepside as a possible adulticidal treatment for human onchocerciasis—The fruit of a successful industrial–academic collaboration

    doi: 10.1371/journal.ppat.1009682

    Figure Lengend Snippet: Chemical structures of the semisynthetic emodepside (A) and its precursor PF1022A (B) purified from Rosellinia spp. PF1022.

    Article Snippet: A patent application was subsequently filed by Fujisawa Pharmaceutical for a bis-morpholino derivative of PF1022A, which was later named emodepside [ ].

    Techniques: Purification