p62 (Proteintech)
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Proteintech
p62
P62, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 2374 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/p62/P62%2FSQSTM1+Antibody/pm42882844-60-17-32
Average 96 stars, based on 2374 article reviews
P62, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 2374 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/p62/P62%2FSQSTM1+Antibody/pm42882844-60-17-32
Average 96 stars, based on 2374 article reviews
p62 - by Bioz Stars,
2026-11
96/100 stars
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Incubation:Article Title: TRPV4-mediated mechanotransduction governs surface topography-induced bone formation via macrophage-osteoclast axis Article Snippet: An inorganic tri‐calcium phosphate ceramic (TCP) with a submicron surface topography (TCP–S) gives rise to bone formation in ectopic sites, while its counterpart with micron surface topography (TCP–B) does not.. We hypothesized that mechanosensitive ion channels act as converters from physical cues (generated by surface topography) to biological responses (bone formation).. Compared to TCP–B, TCP-S activated integrin-mediated focal adhesion complexes, enhanced cytoskeletal tension, and subsequently triggered the Transient Receptor Potential Vanilloid 4 (TRPV4) channel, leading to Ca2+ influx of macrophages in vitro. Article Title: p38 MAPK-associated autophagic response restrains TLR4/MyD88 signaling in RT-treated macrophages. Article Snippet: 16 Ricin toxin (RT) is a highly potent plant-derived toxin that causes severe cellular 17 injury and inflammatory responses, yet effective therapeutic interventions remain 18 limited.. Autophagy is a conserved stress-response pathway that maintains 19 intracellular homeostasis and modulates innate immune signaling.. However, whether 20 autophagy contributes to macrophage adaptation during RT intoxication and how this 21 process is regulated remain incompletely understood. Article Title: A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques Article Snippet: .. To block nonspecific binding, membranes were incubated with 5% skim milk for 1 h. Thereafter, membranes were incubated overnight at 4 °C with primary antibodies against ABCA1, ABCG1, ACOX1, CPT1A, LC3 (ab192890, 1:2000, abcam), LAMP1 (84658-5-RR, 1:8000, Proteintech), PPARα (66826-1-Ig, 1:3000, Proteintech), PPARγ (66936-1-Ig, 1:10000, Proteintech), Article Title: Curculigoside A alleviates metabolic dysfunction-associated steatohepatitis by targeting Rab30 to improve lipid homeostasis. Article Snippet: Background: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by hepatocellular lipid overload, hepatic inflammation, and fibrotic remodeling.. Impaired lipid droplet clearance and fatty acid oxidation (FAO) contribute to MASH progression, yet the molecular regulators coordinating these processes remain insufficiently defined.. Purpose: This study aimed to investigate whether and how Rab30 regulates hepatic lipid homeostasis and to develop a Rab30-related pharmacological intervention strategy for MASH. Cell-Signaling:Article Title: TRPV4-mediated mechanotransduction governs surface topography-induced bone formation via macrophage-osteoclast axis Article Snippet: An inorganic tri‐calcium phosphate ceramic (TCP) with a submicron surface topography (TCP–S) gives rise to bone formation in ectopic sites, while its counterpart with micron surface topography (TCP–B) does not.. We hypothesized that mechanosensitive ion channels act as converters from physical cues (generated by surface topography) to biological responses (bone formation).. Compared to TCP–B, TCP-S activated integrin-mediated focal adhesion complexes, enhanced cytoskeletal tension, and subsequently triggered the Transient Receptor Potential Vanilloid 4 (TRPV4) channel, leading to Ca2+ influx of macrophages in vitro. Article Title: Curculigoside A alleviates metabolic dysfunction-associated steatohepatitis by targeting Rab30 to improve lipid homeostasis. Article Snippet: Background: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by hepatocellular lipid overload, hepatic inflammation, and fibrotic remodeling.. Impaired lipid droplet clearance and fatty acid oxidation (FAO) contribute to MASH progression, yet the molecular regulators coordinating these processes remain insufficiently defined.. Purpose: This study aimed to investigate whether and how Rab30 regulates hepatic lipid homeostasis and to develop a Rab30-related pharmacological intervention strategy for MASH. Article Title: The Novel Organic Arsenical PZ2 Exhibits Potent Anti-T-ALL Activity via ROS-Dependent Apoptosis and GABARAPL1 -Induced Autophagic Cell Death. Article Snippet: Fetal bovine serum (FBS; #10099-141C), RPMI-1640 medium (#21870076), trypsin (#25200056), and PBS (#10010023) were sourced from Gibco (Thermo Fisher Scientific, Waltham, MA, USA). .. Primary antibodies used in this study included: GABARAPL1 (#A23781) and CTSB (#A19005) from Abcam (Cambridge, MA, USA); Blocking Assay:Article Title: p38 MAPK-associated autophagic response restrains TLR4/MyD88 signaling in RT-treated macrophages. Article Snippet: 16 Ricin toxin (RT) is a highly potent plant-derived toxin that causes severe cellular 17 injury and inflammatory responses, yet effective therapeutic interventions remain 18 limited.. Autophagy is a conserved stress-response pathway that maintains 19 intracellular homeostasis and modulates innate immune signaling.. However, whether 20 autophagy contributes to macrophage adaptation during RT intoxication and how this 21 process is regulated remain incompletely understood. Article Title: A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques Article Snippet: .. To block nonspecific binding, membranes were incubated with 5% skim milk for 1 h. Thereafter, membranes were incubated overnight at 4 °C with primary antibodies against ABCA1, ABCG1, ACOX1, CPT1A, LC3 (ab192890, 1:2000, abcam), LAMP1 (84658-5-RR, 1:8000, Proteintech), PPARα (66826-1-Ig, 1:3000, Proteintech), PPARγ (66936-1-Ig, 1:10000, Proteintech), Nonspecific Binding:Article Title: A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques Article Snippet: .. To block nonspecific binding, membranes were incubated with 5% skim milk for 1 h. Thereafter, membranes were incubated overnight at 4 °C with primary antibodies against ABCA1, ABCG1, ACOX1, CPT1A, LC3 (ab192890, 1:2000, abcam), LAMP1 (84658-5-RR, 1:8000, Proteintech), PPARα (66826-1-Ig, 1:3000, Proteintech), PPARγ (66936-1-Ig, 1:10000, Proteintech), Western Blot:Article Title: Curculigoside A alleviates metabolic dysfunction-associated steatohepatitis by targeting Rab30 to improve lipid homeostasis. Article Snippet: Background: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by hepatocellular lipid overload, hepatic inflammation, and fibrotic remodeling.. Impaired lipid droplet clearance and fatty acid oxidation (FAO) contribute to MASH progression, yet the molecular regulators coordinating these processes remain insufficiently defined.. Purpose: This study aimed to investigate whether and how Rab30 regulates hepatic lipid homeostasis and to develop a Rab30-related pharmacological intervention strategy for MASH. |
