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selective dor antagonist  (Santa Cruz Biotechnology)
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<t>DOR</t> activation inhibited inflammatory cytokines release in APP/PS1 mouse and Aβ1-42 oligomer exposed BV2 cell line. C: the control BV2 cells; A: Aβ1-42 oligomer exposed BV2 cells; U: UFP-512; <t>N:</t> <t>naltrindole;</t> D: DAMGO; X: naltrexone. ( A ) Evaluation of the inflammatory events in the cortex and hippocampus region of WT mice and APP/PS1 mice. n = 4. Cortex: TNF-α: * p = 0.0218 vs. WT. IL-1β: * p = 0.0203 vs. WT. Hippocampus: TNF-α: * p = 0.0286 vs. WT. IL-1β: ** p = 0.0080 vs. WT. Unpaired t test was used to analyze the statistical significance. ( B , C )Effects of DOR and MOR on inflammatory cytokines in the cortex and hippocampus of APP/PS1 mice. n = 3. Cortex: TNF-α: *** p = 0.0004, ** p = 0.0068 or 0.0050 vs. WT; Δ p = 0.0477 vs. AD. IL-1β: *** p = 0.0005 vs. WT; Δ p = 0.0149 vs. AD. Hippocampus: TNF-α: **** p < 0.0001, * p = 0.0133 vs. WT; Δ p = 0.0288 vs. AD. IL-1β: **** p < 0.0001, * p = 0.0291 or 0.0217 vs. WT; Δ p = 0.0467 vs. AD. Unpaired t test was used to analyze the statistical significance. ( D ) Aβ1-42 oligomer induced changes in proinflammatory cytokines in BV2 cell line. n = 3. TNF-α: * p = 0.0329, ** p = 0.0039, *** p = 0.0005 vs. C. IL-1β: **** p < 0.0001 vs. C. One-way ANOVA was used to analyze statistical significance. ( E , F ) Effects of DOR and MOR on TNF-α and IL-1β in Aβ1-42 exposed BV2 cells. n = 3. TNF-α: (E): **** p < 0.0001, *** p = 0.0006 vs. C. ΔΔ p = 0.0061 vs. A. (F): *** p = 0.0001 or 0.0004, ** p = 0.0012 vs. C. IL-1β: (E): **** p < 0.0001, ** p = 0.0013 vs. C. ΔΔ p = 0.0071 vs. A. (F): *** p = 0.0004, ** p = 0.0011 or 0.0051 vs. C. One-way ANOVA was used to analyze the statistical significance
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naltrindole hydrochloride  (Santa Cruz Biotechnology)
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DOR activation inhibited inflammatory cytokines release in APP/PS1 mouse and Aβ1-42 oligomer exposed BV2 cell line. C: the control BV2 cells; A: Aβ1-42 oligomer exposed BV2 cells; U: UFP-512; N: <t>naltrindole;</t> D: DAMGO; X: naltrexone. ( A ) Evaluation of the inflammatory events in the cortex and hippocampus region of WT mice and APP/PS1 mice. n = 4. Cortex: TNF-α: * p = 0.0218 vs. WT. IL-1β: * p = 0.0203 vs. WT. Hippocampus: TNF-α: * p = 0.0286 vs. WT. IL-1β: ** p = 0.0080 vs. WT. Unpaired t test was used to analyze the statistical significance. ( B , C )Effects of DOR and MOR on inflammatory cytokines in the cortex and hippocampus of APP/PS1 mice. n = 3. Cortex: TNF-α: *** p = 0.0004, ** p = 0.0068 or 0.0050 vs. WT; Δ p = 0.0477 vs. AD. IL-1β: *** p = 0.0005 vs. WT; Δ p = 0.0149 vs. AD. Hippocampus: TNF-α: **** p < 0.0001, * p = 0.0133 vs. WT; Δ p = 0.0288 vs. AD. IL-1β: **** p < 0.0001, * p = 0.0291 or 0.0217 vs. WT; Δ p = 0.0467 vs. AD. Unpaired t test was used to analyze the statistical significance. ( D ) Aβ1-42 oligomer induced changes in proinflammatory cytokines in BV2 cell line. n = 3. TNF-α: * p = 0.0329, ** p = 0.0039, *** p = 0.0005 vs. C. IL-1β: **** p < 0.0001 vs. C. One-way ANOVA was used to analyze statistical significance. ( E , F ) Effects of DOR and MOR on TNF-α and IL-1β in Aβ1-42 exposed BV2 cells. n = 3. TNF-α: (E): **** p < 0.0001, *** p = 0.0006 vs. C. ΔΔ p = 0.0061 vs. A. (F): *** p = 0.0001 or 0.0004, ** p = 0.0012 vs. C. IL-1β: (E): **** p < 0.0001, ** p = 0.0013 vs. C. ΔΔ p = 0.0071 vs. A. (F): *** p = 0.0004, ** p = 0.0011 or 0.0051 vs. C. One-way ANOVA was used to analyze the statistical significance
Naltrindole Hydrochloride, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/naltrindole hydrochloride/product/Santa Cruz Biotechnology
Average 94 stars, based on 1 article reviews
naltrindole hydrochloride - by Bioz Stars, 2026-02
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naltrindole  (Merck KGaA)
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Merck KGaA naltrindole
DOR activation inhibited inflammatory cytokines release in APP/PS1 mouse and Aβ1-42 oligomer exposed BV2 cell line. C: the control BV2 cells; A: Aβ1-42 oligomer exposed BV2 cells; U: UFP-512; N: <t>naltrindole;</t> D: DAMGO; X: naltrexone. ( A ) Evaluation of the inflammatory events in the cortex and hippocampus region of WT mice and APP/PS1 mice. n = 4. Cortex: TNF-α: * p = 0.0218 vs. WT. IL-1β: * p = 0.0203 vs. WT. Hippocampus: TNF-α: * p = 0.0286 vs. WT. IL-1β: ** p = 0.0080 vs. WT. Unpaired t test was used to analyze the statistical significance. ( B , C )Effects of DOR and MOR on inflammatory cytokines in the cortex and hippocampus of APP/PS1 mice. n = 3. Cortex: TNF-α: *** p = 0.0004, ** p = 0.0068 or 0.0050 vs. WT; Δ p = 0.0477 vs. AD. IL-1β: *** p = 0.0005 vs. WT; Δ p = 0.0149 vs. AD. Hippocampus: TNF-α: **** p < 0.0001, * p = 0.0133 vs. WT; Δ p = 0.0288 vs. AD. IL-1β: **** p < 0.0001, * p = 0.0291 or 0.0217 vs. WT; Δ p = 0.0467 vs. AD. Unpaired t test was used to analyze the statistical significance. ( D ) Aβ1-42 oligomer induced changes in proinflammatory cytokines in BV2 cell line. n = 3. TNF-α: * p = 0.0329, ** p = 0.0039, *** p = 0.0005 vs. C. IL-1β: **** p < 0.0001 vs. C. One-way ANOVA was used to analyze statistical significance. ( E , F ) Effects of DOR and MOR on TNF-α and IL-1β in Aβ1-42 exposed BV2 cells. n = 3. TNF-α: (E): **** p < 0.0001, *** p = 0.0006 vs. C. ΔΔ p = 0.0061 vs. A. (F): *** p = 0.0001 or 0.0004, ** p = 0.0012 vs. C. IL-1β: (E): **** p < 0.0001, ** p = 0.0013 vs. C. ΔΔ p = 0.0071 vs. A. (F): *** p = 0.0004, ** p = 0.0011 or 0.0051 vs. C. One-way ANOVA was used to analyze the statistical significance
Naltrindole, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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Image Search Results


Journal: Cell reports

Article Title: Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity

doi: 10.1016/j.celrep.2025.115293

Figure Lengend Snippet:

Article Snippet: Naltrindole , Tocris , 0740.

Techniques: Virus, Recombinant, Software

DOR activation inhibited inflammatory cytokines release in APP/PS1 mouse and Aβ1-42 oligomer exposed BV2 cell line. C: the control BV2 cells; A: Aβ1-42 oligomer exposed BV2 cells; U: UFP-512; N: naltrindole; D: DAMGO; X: naltrexone. ( A ) Evaluation of the inflammatory events in the cortex and hippocampus region of WT mice and APP/PS1 mice. n = 4. Cortex: TNF-α: * p = 0.0218 vs. WT. IL-1β: * p = 0.0203 vs. WT. Hippocampus: TNF-α: * p = 0.0286 vs. WT. IL-1β: ** p = 0.0080 vs. WT. Unpaired t test was used to analyze the statistical significance. ( B , C )Effects of DOR and MOR on inflammatory cytokines in the cortex and hippocampus of APP/PS1 mice. n = 3. Cortex: TNF-α: *** p = 0.0004, ** p = 0.0068 or 0.0050 vs. WT; Δ p = 0.0477 vs. AD. IL-1β: *** p = 0.0005 vs. WT; Δ p = 0.0149 vs. AD. Hippocampus: TNF-α: **** p < 0.0001, * p = 0.0133 vs. WT; Δ p = 0.0288 vs. AD. IL-1β: **** p < 0.0001, * p = 0.0291 or 0.0217 vs. WT; Δ p = 0.0467 vs. AD. Unpaired t test was used to analyze the statistical significance. ( D ) Aβ1-42 oligomer induced changes in proinflammatory cytokines in BV2 cell line. n = 3. TNF-α: * p = 0.0329, ** p = 0.0039, *** p = 0.0005 vs. C. IL-1β: **** p < 0.0001 vs. C. One-way ANOVA was used to analyze statistical significance. ( E , F ) Effects of DOR and MOR on TNF-α and IL-1β in Aβ1-42 exposed BV2 cells. n = 3. TNF-α: (E): **** p < 0.0001, *** p = 0.0006 vs. C. ΔΔ p = 0.0061 vs. A. (F): *** p = 0.0001 or 0.0004, ** p = 0.0012 vs. C. IL-1β: (E): **** p < 0.0001, ** p = 0.0013 vs. C. ΔΔ p = 0.0071 vs. A. (F): *** p = 0.0004, ** p = 0.0011 or 0.0051 vs. C. One-way ANOVA was used to analyze the statistical significance

Journal: Alzheimer's Research & Therapy

Article Title: Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer’s disease by regulating microglia homeostasis and inhibiting HMGB1 pathway

doi: 10.1186/s13195-025-01682-1

Figure Lengend Snippet: DOR activation inhibited inflammatory cytokines release in APP/PS1 mouse and Aβ1-42 oligomer exposed BV2 cell line. C: the control BV2 cells; A: Aβ1-42 oligomer exposed BV2 cells; U: UFP-512; N: naltrindole; D: DAMGO; X: naltrexone. ( A ) Evaluation of the inflammatory events in the cortex and hippocampus region of WT mice and APP/PS1 mice. n = 4. Cortex: TNF-α: * p = 0.0218 vs. WT. IL-1β: * p = 0.0203 vs. WT. Hippocampus: TNF-α: * p = 0.0286 vs. WT. IL-1β: ** p = 0.0080 vs. WT. Unpaired t test was used to analyze the statistical significance. ( B , C )Effects of DOR and MOR on inflammatory cytokines in the cortex and hippocampus of APP/PS1 mice. n = 3. Cortex: TNF-α: *** p = 0.0004, ** p = 0.0068 or 0.0050 vs. WT; Δ p = 0.0477 vs. AD. IL-1β: *** p = 0.0005 vs. WT; Δ p = 0.0149 vs. AD. Hippocampus: TNF-α: **** p < 0.0001, * p = 0.0133 vs. WT; Δ p = 0.0288 vs. AD. IL-1β: **** p < 0.0001, * p = 0.0291 or 0.0217 vs. WT; Δ p = 0.0467 vs. AD. Unpaired t test was used to analyze the statistical significance. ( D ) Aβ1-42 oligomer induced changes in proinflammatory cytokines in BV2 cell line. n = 3. TNF-α: * p = 0.0329, ** p = 0.0039, *** p = 0.0005 vs. C. IL-1β: **** p < 0.0001 vs. C. One-way ANOVA was used to analyze statistical significance. ( E , F ) Effects of DOR and MOR on TNF-α and IL-1β in Aβ1-42 exposed BV2 cells. n = 3. TNF-α: (E): **** p < 0.0001, *** p = 0.0006 vs. C. ΔΔ p = 0.0061 vs. A. (F): *** p = 0.0001 or 0.0004, ** p = 0.0012 vs. C. IL-1β: (E): **** p < 0.0001, ** p = 0.0013 vs. C. ΔΔ p = 0.0071 vs. A. (F): *** p = 0.0004, ** p = 0.0011 or 0.0051 vs. C. One-way ANOVA was used to analyze the statistical significance

Article Snippet: Naltrindole hydrochloride, a selective DOR antagonist, was purchased from Santa Cruz (Cat: sc-202236, USA).

Techniques: Activation Assay, Control

DOR activation inhibited inflammatory cytokines release in APP/PS1 mouse and Aβ1-42 oligomer exposed BV2 cell line. C: the control BV2 cells; A: Aβ1-42 oligomer exposed BV2 cells; U: UFP-512; N: naltrindole; D: DAMGO; X: naltrexone. ( A ) Evaluation of the inflammatory events in the cortex and hippocampus region of WT mice and APP/PS1 mice. n = 4. Cortex: TNF-α: * p = 0.0218 vs. WT. IL-1β: * p = 0.0203 vs. WT. Hippocampus: TNF-α: * p = 0.0286 vs. WT. IL-1β: ** p = 0.0080 vs. WT. Unpaired t test was used to analyze the statistical significance. ( B , C )Effects of DOR and MOR on inflammatory cytokines in the cortex and hippocampus of APP/PS1 mice. n = 3. Cortex: TNF-α: *** p = 0.0004, ** p = 0.0068 or 0.0050 vs. WT; Δ p = 0.0477 vs. AD. IL-1β: *** p = 0.0005 vs. WT; Δ p = 0.0149 vs. AD. Hippocampus: TNF-α: **** p < 0.0001, * p = 0.0133 vs. WT; Δ p = 0.0288 vs. AD. IL-1β: **** p < 0.0001, * p = 0.0291 or 0.0217 vs. WT; Δ p = 0.0467 vs. AD. Unpaired t test was used to analyze the statistical significance. ( D ) Aβ1-42 oligomer induced changes in proinflammatory cytokines in BV2 cell line. n = 3. TNF-α: * p = 0.0329, ** p = 0.0039, *** p = 0.0005 vs. C. IL-1β: **** p < 0.0001 vs. C. One-way ANOVA was used to analyze statistical significance. ( E , F ) Effects of DOR and MOR on TNF-α and IL-1β in Aβ1-42 exposed BV2 cells. n = 3. TNF-α: (E): **** p < 0.0001, *** p = 0.0006 vs. C. ΔΔ p = 0.0061 vs. A. (F): *** p = 0.0001 or 0.0004, ** p = 0.0012 vs. C. IL-1β: (E): **** p < 0.0001, ** p = 0.0013 vs. C. ΔΔ p = 0.0071 vs. A. (F): *** p = 0.0004, ** p = 0.0011 or 0.0051 vs. C. One-way ANOVA was used to analyze the statistical significance

Journal: Alzheimer's Research & Therapy

Article Title: Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer’s disease by regulating microglia homeostasis and inhibiting HMGB1 pathway

doi: 10.1186/s13195-025-01682-1

Figure Lengend Snippet: DOR activation inhibited inflammatory cytokines release in APP/PS1 mouse and Aβ1-42 oligomer exposed BV2 cell line. C: the control BV2 cells; A: Aβ1-42 oligomer exposed BV2 cells; U: UFP-512; N: naltrindole; D: DAMGO; X: naltrexone. ( A ) Evaluation of the inflammatory events in the cortex and hippocampus region of WT mice and APP/PS1 mice. n = 4. Cortex: TNF-α: * p = 0.0218 vs. WT. IL-1β: * p = 0.0203 vs. WT. Hippocampus: TNF-α: * p = 0.0286 vs. WT. IL-1β: ** p = 0.0080 vs. WT. Unpaired t test was used to analyze the statistical significance. ( B , C )Effects of DOR and MOR on inflammatory cytokines in the cortex and hippocampus of APP/PS1 mice. n = 3. Cortex: TNF-α: *** p = 0.0004, ** p = 0.0068 or 0.0050 vs. WT; Δ p = 0.0477 vs. AD. IL-1β: *** p = 0.0005 vs. WT; Δ p = 0.0149 vs. AD. Hippocampus: TNF-α: **** p < 0.0001, * p = 0.0133 vs. WT; Δ p = 0.0288 vs. AD. IL-1β: **** p < 0.0001, * p = 0.0291 or 0.0217 vs. WT; Δ p = 0.0467 vs. AD. Unpaired t test was used to analyze the statistical significance. ( D ) Aβ1-42 oligomer induced changes in proinflammatory cytokines in BV2 cell line. n = 3. TNF-α: * p = 0.0329, ** p = 0.0039, *** p = 0.0005 vs. C. IL-1β: **** p < 0.0001 vs. C. One-way ANOVA was used to analyze statistical significance. ( E , F ) Effects of DOR and MOR on TNF-α and IL-1β in Aβ1-42 exposed BV2 cells. n = 3. TNF-α: (E): **** p < 0.0001, *** p = 0.0006 vs. C. ΔΔ p = 0.0061 vs. A. (F): *** p = 0.0001 or 0.0004, ** p = 0.0012 vs. C. IL-1β: (E): **** p < 0.0001, ** p = 0.0013 vs. C. ΔΔ p = 0.0071 vs. A. (F): *** p = 0.0004, ** p = 0.0011 or 0.0051 vs. C. One-way ANOVA was used to analyze the statistical significance

Article Snippet: Naltrindole hydrochloride, a selective DOR antagonist, was purchased from Santa Cruz (Cat: sc-202236, USA).

Techniques: Activation Assay, Control