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  • 94
    Millipore naltrindole
    Opioid receptor selectivity of selected TPI-2213 series compounds. Bars = 8 mice each. TPI-2213 compounds administered i.p. at ED 90 dose (or higher) in MOR KO mice (striped bars) or wild-type mice with or without pretreatment with nor-BNI (10 mg/kg, i.p., – 24 h; criss crossed or <t>naltrindole</t> (20 mg/kg, i.p., −20 min, dotted bars). 2213-54 was tested in KOR KO mice instead of wild-type mice pretreated with nor-BNI. Antinociception was measured 30 min after administration of the TPI-2213 compound. * = Significantly different from baseline latency. † = Significantly less than matching 2213 compound alone, p
    Naltrindole, supplied by Millipore, used in various techniques. Bioz Stars score: 94/100, based on 155 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    94
    Tocris naltrindole
    Dose‐ and time‐dependent antiallodynic effect of intraperitoneal cebranopadol after IP pretreatment with vehicle (A), J‐113397 (4.64 mg/kg, (B)), naloxone (1 mg/kg, (C)), <t>naltrindole</t> (10 mg/kg, (D)), and nor‐ BNI (10 mg/kg, (E)). Dose‐response curves of cebranopadol after pretreatment with vehicle or antagonists 20 minutes after agonist administration (F). * P
    Naltrindole, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 111 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/naltrindole/product/Tocris
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    88
    PerkinElmer h naltrindole
    Effect of RTX treatment on the δ-opioid receptor binding in the dorsal spinal cord. Comparison of specific [ 3 <t>H]-naltrindole</t> binding to rat dorsal spinal cord membranes from rats treated with vehicle or RTX (n = 4 replicates in each group).
    H Naltrindole, supplied by PerkinElmer, used in various techniques. Bioz Stars score: 88/100, based on 29 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    88
    Cedarlane naltrindole hydrochloride nti
    Effect of RTX treatment on the δ-opioid receptor binding in the dorsal spinal cord. Comparison of specific [ 3 <t>H]-naltrindole</t> binding to rat dorsal spinal cord membranes from rats treated with vehicle or RTX (n = 4 replicates in each group).
    Naltrindole Hydrochloride Nti, supplied by Cedarlane, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    90
    Sinopharm naltrindole
    Effect of RTX treatment on the δ-opioid receptor binding in the dorsal spinal cord. Comparison of specific [ 3 <t>H]-naltrindole</t> binding to rat dorsal spinal cord membranes from rats treated with vehicle or RTX (n = 4 replicates in each group).
    Naltrindole, supplied by Sinopharm, used in various techniques. Bioz Stars score: 90/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Abcam naltrindole
    Effect of RTX treatment on the δ-opioid receptor binding in the dorsal spinal cord. Comparison of specific [ 3 <t>H]-naltrindole</t> binding to rat dorsal spinal cord membranes from rats treated with vehicle or RTX (n = 4 replicates in each group).
    Naltrindole, supplied by Abcam, used in various techniques. Bioz Stars score: 90/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Opioid receptor selectivity of selected TPI-2213 series compounds. Bars = 8 mice each. TPI-2213 compounds administered i.p. at ED 90 dose (or higher) in MOR KO mice (striped bars) or wild-type mice with or without pretreatment with nor-BNI (10 mg/kg, i.p., – 24 h; criss crossed or naltrindole (20 mg/kg, i.p., −20 min, dotted bars). 2213-54 was tested in KOR KO mice instead of wild-type mice pretreated with nor-BNI. Antinociception was measured 30 min after administration of the TPI-2213 compound. * = Significantly different from baseline latency. † = Significantly less than matching 2213 compound alone, p

    Journal: ACS Combinatorial Science

    Article Title: Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines

    doi: 10.1021/acscombsci.5b00126

    Figure Lengend Snippet: Opioid receptor selectivity of selected TPI-2213 series compounds. Bars = 8 mice each. TPI-2213 compounds administered i.p. at ED 90 dose (or higher) in MOR KO mice (striped bars) or wild-type mice with or without pretreatment with nor-BNI (10 mg/kg, i.p., – 24 h; criss crossed or naltrindole (20 mg/kg, i.p., −20 min, dotted bars). 2213-54 was tested in KOR KO mice instead of wild-type mice pretreated with nor-BNI. Antinociception was measured 30 min after administration of the TPI-2213 compound. * = Significantly different from baseline latency. † = Significantly less than matching 2213 compound alone, p

    Article Snippet: Morphine sulfate, naloxone, nor-binaltorphimine (nor-BNI), and naltrindole were purchased from Sigma-Aldrich (St. Louis, MO) and dissolved in 0.9% sterile saline.

    Techniques: Mouse Assay

    Agonist-induced internalization of cell surface µ-opioid receptors (µOR) detected by [ 3 H]-DAMGO in intact HEK 293T cells co-expressing µ- and δ-receptors (δOR), and treated with 100 nM naltrindole or 1 µM CTOP (A), or only expressing µ-receptors (B). Cells co-expressing µ- and δ-receptors were pretreated with 100 nM naltrindole or 1 µM CTOP for 30 min at 37°C, rinsed, then treated with 10 µM agonist for 1 h at 37°C (A). Cells expressing only µ-receptors were treated with 10 µM agonist for 1 h at 37°C (B). Data shown represent drug-induced loss of cell surface receptors as a percentage of cell surface receptors in vehicle-treated control cells, and are expressed as mean ± SEM for n = 3–5 experiments performed in triplicate. Nd = not determined. Statistical significance in (A) was determined using an unpaired Student's t -test [* P

    Journal: British Journal of Pharmacology

    Article Title: Agonists at the ?-opioid receptor modify the binding of u-receptor agonists to the u-? receptor hetero-oligomer

    doi: 10.1111/j.1476-5381.2010.00944.x

    Figure Lengend Snippet: Agonist-induced internalization of cell surface µ-opioid receptors (µOR) detected by [ 3 H]-DAMGO in intact HEK 293T cells co-expressing µ- and δ-receptors (δOR), and treated with 100 nM naltrindole or 1 µM CTOP (A), or only expressing µ-receptors (B). Cells co-expressing µ- and δ-receptors were pretreated with 100 nM naltrindole or 1 µM CTOP for 30 min at 37°C, rinsed, then treated with 10 µM agonist for 1 h at 37°C (A). Cells expressing only µ-receptors were treated with 10 µM agonist for 1 h at 37°C (B). Data shown represent drug-induced loss of cell surface receptors as a percentage of cell surface receptors in vehicle-treated control cells, and are expressed as mean ± SEM for n = 3–5 experiments performed in triplicate. Nd = not determined. Statistical significance in (A) was determined using an unpaired Student's t -test [* P

    Article Snippet: Deltorphin II, DAMGO, DPDPE, naltrindole hydrochloride, SNC80, Leu-enkephalin, Met-enkephalin, endomorphin-1 and naloxone hydrochloride were purchased from Sigma.

    Techniques: Expressing

    Opioid receptor antagonist and agonist modulation MOR- or DOR-specific ligand binding in NK cells. Shown are representative saturation curves ( A, C, E, and G ) and the B max ( B, D, F, and H ) of MOR-specific ligand [ 3 H]DAMGO or DOR-specific ligand [ 3 H]naltrindole.

    Journal: The Journal of Biological Chemistry

    Article Title: Opiate Antagonist Prevents ?- and ?-Opiate Receptor Dimerization to Facilitate Ability of Agonist to Control Ethanol-altered Natural Killer Cell Functions and Mammary Tumor Growth *

    doi: 10.1074/jbc.M112.347583

    Figure Lengend Snippet: Opioid receptor antagonist and agonist modulation MOR- or DOR-specific ligand binding in NK cells. Shown are representative saturation curves ( A, C, E, and G ) and the B max ( B, D, F, and H ) of MOR-specific ligand [ 3 H]DAMGO or DOR-specific ligand [ 3 H]naltrindole.

    Article Snippet: Unlabeled naltrindole (50 μ m ; Sigma) and DAMGO (50 μ m ; Sigma) were used to assess nonspecific binding.

    Techniques: Ligand Binding Assay

    Effects of i.c.v. administration of β-FNA (10 nmol), nor-BNI (10 nmol) and naltrindole (10 nmol) on the EM-1 (7.5 nmol i.c.v.) (A) or EM-2 (7.5 nmol i.c.v.) (B) induced central antinociception in mouse tail-flick test. Data are expressed as differences in AUC between endomorphins (7.5 nmol) and endomorphins co-injected with β-FNA, nor-BNI or NTI during 0–30 min. Each value represents mean ± S.E.M. (n = 7–12 mice/group). ***p

    Journal: PLoS ONE

    Article Title: Opposite Effects of Neuropeptide FF on Central Antinociception Induced by Endomorphin-1 and Endomorphin-2 in Mice

    doi: 10.1371/journal.pone.0103773

    Figure Lengend Snippet: Effects of i.c.v. administration of β-FNA (10 nmol), nor-BNI (10 nmol) and naltrindole (10 nmol) on the EM-1 (7.5 nmol i.c.v.) (A) or EM-2 (7.5 nmol i.c.v.) (B) induced central antinociception in mouse tail-flick test. Data are expressed as differences in AUC between endomorphins (7.5 nmol) and endomorphins co-injected with β-FNA, nor-BNI or NTI during 0–30 min. Each value represents mean ± S.E.M. (n = 7–12 mice/group). ***p

    Article Snippet: In addition, the µ-opioid receptor selective agonist DAMGO ([D-Ala2 , N-MePhe4 , Gly-ol]-enkephalin), κ-opioid receptor selective agonist U69593 ([5a,7a,8b]-(+)-N -methyl-N -[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl] benzeneacetamide) and µ-, κ- and δ-opioid receptors selective antagonists beta-funaltrexamine (β-FNA), nor-binaltorphimine (nor-BNI) and naltrindole (NTI) respectively, were purchased from Sigma Chemical Company (USA).

    Techniques: Tail Flick Test, Injection, Mouse Assay

    Naltrindole blocks the effect of vE on p38 and PKC in DRG exposed to hyperglycemia in vitro

    Journal: The Journal of Neuroscience

    Article Title: Continuous delta opioid receptor activation reduces neuronal voltage gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy

    doi: 10.1523/JNEUROSCI.5530-07.2008

    Figure Lengend Snippet: Naltrindole blocks the effect of vE on p38 and PKC in DRG exposed to hyperglycemia in vitro

    Article Snippet: For the naltrindole experiments, 10 pM naltrindole (Sigma, St. Louis, MO) was added 1 hr before exposure to high glucose and another 10 pM was added for 1 hr before termination of the experiment (because of the continuous production of PE by the vector).

    Techniques: In Vitro

    Dose‐ and time‐dependent antiallodynic effect of intraperitoneal cebranopadol after IP pretreatment with vehicle (A), J‐113397 (4.64 mg/kg, (B)), naloxone (1 mg/kg, (C)), naltrindole (10 mg/kg, (D)), and nor‐ BNI (10 mg/kg, (E)). Dose‐response curves of cebranopadol after pretreatment with vehicle or antagonists 20 minutes after agonist administration (F). * P

    Journal: Pharmacology Research & Perspectives

    Article Title: Synergistic interaction between the agonism of cebranopadol at nociceptin/orphanin FQ and classical opioid receptors in the rat spinal nerve ligation model. Synergistic interaction between the agonism of cebranopadol at nociceptin/orphanin FQ and classical opioid receptors in the rat spinal nerve ligation model

    doi: 10.1002/prp2.444

    Figure Lengend Snippet: Dose‐ and time‐dependent antiallodynic effect of intraperitoneal cebranopadol after IP pretreatment with vehicle (A), J‐113397 (4.64 mg/kg, (B)), naloxone (1 mg/kg, (C)), naltrindole (10 mg/kg, (D)), and nor‐ BNI (10 mg/kg, (E)). Dose‐response curves of cebranopadol after pretreatment with vehicle or antagonists 20 minutes after agonist administration (F). * P

    Article Snippet: 2.5 Drugs and chemicals The following drugs were used: cebranopadol hemi‐citrate (Grünenthal GmbH, Aachen, Germany), J‐113397 (CAS no.: 2177461‐40‐0; Grünenthal GmbH, Aachen, Germany), sodium pentobarbital (CAS no.: 57‐33‐0; Narcoren® ), naloxone HCl (CAS no.: 51481‐60‐8; Sigma‐Aldrich Chemie GmbH, Taufkirchen, Germany), naltrindole (CAS no.: 111469‐81‐9; Tocris, Bristol, UK), and nor‐BNI dihydrochloride (CAS no.: 105618‐26‐6; Biotrend, Cologne, Germany).

    Techniques:

    Dose‐ and time‐dependent antiallodynic effect of intraperitoneal cebranopadol after IP pretreatment with a triple combination of opioid receptor antagonists (naloxone 1 mg/kg, naltrindole 10 mg/kg, and nor‐ BNI 10 mg/kg, (A)) and the corresponding vehicle control (B). Dose‐response curves of cebranopadol after pretreatment with vehicle or antagonists 20 minutes after agonist administration (C). * P

    Journal: Pharmacology Research & Perspectives

    Article Title: Synergistic interaction between the agonism of cebranopadol at nociceptin/orphanin FQ and classical opioid receptors in the rat spinal nerve ligation model. Synergistic interaction between the agonism of cebranopadol at nociceptin/orphanin FQ and classical opioid receptors in the rat spinal nerve ligation model

    doi: 10.1002/prp2.444

    Figure Lengend Snippet: Dose‐ and time‐dependent antiallodynic effect of intraperitoneal cebranopadol after IP pretreatment with a triple combination of opioid receptor antagonists (naloxone 1 mg/kg, naltrindole 10 mg/kg, and nor‐ BNI 10 mg/kg, (A)) and the corresponding vehicle control (B). Dose‐response curves of cebranopadol after pretreatment with vehicle or antagonists 20 minutes after agonist administration (C). * P

    Article Snippet: 2.5 Drugs and chemicals The following drugs were used: cebranopadol hemi‐citrate (Grünenthal GmbH, Aachen, Germany), J‐113397 (CAS no.: 2177461‐40‐0; Grünenthal GmbH, Aachen, Germany), sodium pentobarbital (CAS no.: 57‐33‐0; Narcoren® ), naloxone HCl (CAS no.: 51481‐60‐8; Sigma‐Aldrich Chemie GmbH, Taufkirchen, Germany), naltrindole (CAS no.: 111469‐81‐9; Tocris, Bristol, UK), and nor‐BNI dihydrochloride (CAS no.: 105618‐26‐6; Biotrend, Cologne, Germany).

    Techniques:

    The influence of opioid antagonists: β-FNA (5 nmol, i.c.v., 24 h before test), naltrindole (5 nmol, i.c.v., 5 min before test), and nor-BNI (10 nmol, i.c.v., 1 h before test) on DEL-6 (20 nmol, i.c.v.) induced antinociception in the tail-immersion

    Journal: Peptides

    Article Title: Antinociceptive effects of two deltorphins analogs in the tail-immersion test in rats

    doi: 10.1016/j.peptides.2012.11.008

    Figure Lengend Snippet: The influence of opioid antagonists: β-FNA (5 nmol, i.c.v., 24 h before test), naltrindole (5 nmol, i.c.v., 5 min before test), and nor-BNI (10 nmol, i.c.v., 1 h before test) on DEL-6 (20 nmol, i.c.v.) induced antinociception in the tail-immersion

    Article Snippet: Naltrindole hydrochloride (NTI, 5 nmol), β-funaltrexamine hydrochloride (β-FNA, 5 nmol) and nor-binaltorphimine hydrochloride (nor-BNI, 10 nmol) were purchased from Tocris Cookson Ltd. (Bristol, UK).

    Techniques:

    The influence of opioid antagonists: β-FNA (5 nmol, i.c.v., 24 h before test), naltrindole (5 nmol, i.c.v., 5 min before test), and nor-BNI (10 nmol, i.c.v., 1 h before test) on DK-4 (20 nmol, i.c.v.) induced antinociception in the tail-immersion

    Journal: Peptides

    Article Title: Antinociceptive effects of two deltorphins analogs in the tail-immersion test in rats

    doi: 10.1016/j.peptides.2012.11.008

    Figure Lengend Snippet: The influence of opioid antagonists: β-FNA (5 nmol, i.c.v., 24 h before test), naltrindole (5 nmol, i.c.v., 5 min before test), and nor-BNI (10 nmol, i.c.v., 1 h before test) on DK-4 (20 nmol, i.c.v.) induced antinociception in the tail-immersion

    Article Snippet: Naltrindole hydrochloride (NTI, 5 nmol), β-funaltrexamine hydrochloride (β-FNA, 5 nmol) and nor-binaltorphimine hydrochloride (nor-BNI, 10 nmol) were purchased from Tocris Cookson Ltd. (Bristol, UK).

    Techniques:

    Two distinct binding sites are observed for the ligands morphine and M6S at the delta–opioid receptor (delta-OR). (A) - The delta–OR protein (PDB 4N6H) is shown as a wheat cartoon. The dashed circle indicates the location of the ligand binding site (LBS) on the delta–OR occupied by naltrindole in the crystal structure. Distribution of the top 10 docked poses of morphine ( magenta ), M6S ( cyan ) and the non-selective antagonist naltrexone ( yellow ) between the LBS and the allosteric site (see text) are shown. As can be clearly seen, a majority of the docked poses of morphine bind at the allosteric site, while only one pose binds at the LBS. In contrast, for M6S, a majority of poses (8 out of 10) including the top-scoring pose, are bound at the LBS on the receptor. The top 10 docked poses for naltrexone are distributed equally between the two sites. (B) - Atomic contacts of naltrindole, morphine and M6S at the LBS of the delta–OR. The antagonist naltrindole ( yellow ) is bound at the LBS in the co-crystal structure with the delta–OR, and makes polar contacts with two delta–OR residues, Asp128 and Tyr129. These contacts and many of the van der Waals’ contacts of other delta–OR residues are common between naltrindole, and morphine ( magenta ). The lone docked pose of morphine (FF score −1090 kcal/mol) shown here makes fewer van der Waals’ contacts with delta–OR residues as compared to naltrindole at the LBS. In contrast, the top-scoring docked pose of M6S ( cyan ) shown here (FF score −1118 kcal/mol) makes an ionic interaction through its sulfate group to the side-chain of Lys214 of the delta–OR, as well as van der Waals’ contacts with other residues common with morphine.

    Journal: Pharmacological research

    Article Title: Antinociceptive effects of the 6-O-sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors

    doi: 10.1016/j.phrs.2016.09.012

    Figure Lengend Snippet: Two distinct binding sites are observed for the ligands morphine and M6S at the delta–opioid receptor (delta-OR). (A) - The delta–OR protein (PDB 4N6H) is shown as a wheat cartoon. The dashed circle indicates the location of the ligand binding site (LBS) on the delta–OR occupied by naltrindole in the crystal structure. Distribution of the top 10 docked poses of morphine ( magenta ), M6S ( cyan ) and the non-selective antagonist naltrexone ( yellow ) between the LBS and the allosteric site (see text) are shown. As can be clearly seen, a majority of the docked poses of morphine bind at the allosteric site, while only one pose binds at the LBS. In contrast, for M6S, a majority of poses (8 out of 10) including the top-scoring pose, are bound at the LBS on the receptor. The top 10 docked poses for naltrexone are distributed equally between the two sites. (B) - Atomic contacts of naltrindole, morphine and M6S at the LBS of the delta–OR. The antagonist naltrindole ( yellow ) is bound at the LBS in the co-crystal structure with the delta–OR, and makes polar contacts with two delta–OR residues, Asp128 and Tyr129. These contacts and many of the van der Waals’ contacts of other delta–OR residues are common between naltrindole, and morphine ( magenta ). The lone docked pose of morphine (FF score −1090 kcal/mol) shown here makes fewer van der Waals’ contacts with delta–OR residues as compared to naltrindole at the LBS. In contrast, the top-scoring docked pose of M6S ( cyan ) shown here (FF score −1118 kcal/mol) makes an ionic interaction through its sulfate group to the side-chain of Lys214 of the delta–OR, as well as van der Waals’ contacts with other residues common with morphine.

    Article Snippet: The delta-OR selective antagonist naltrindole hydrochloride (NLD) was purchased from Tocris Biosciences (Minneapolis, MN).

    Techniques: Binding Assay, Ligand Binding Assay

    Comparison of tolerance and cross-tolerance profiles for M6S and morphine and the effect of the delta-specific antagonist naltrindole on both drugs. (A) - The effect of M6S (3 mg/kg) on TWL in the presence of opioid receptor antagonists (non-subtype-specific, NTX; kappa-OR-specific, Nor-BNI; and delta-OR-specific, NLD) relative to that without OR blockade. Asterisks – difference from other two groups at p

    Journal: Pharmacological research

    Article Title: Antinociceptive effects of the 6-O-sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors

    doi: 10.1016/j.phrs.2016.09.012

    Figure Lengend Snippet: Comparison of tolerance and cross-tolerance profiles for M6S and morphine and the effect of the delta-specific antagonist naltrindole on both drugs. (A) - The effect of M6S (3 mg/kg) on TWL in the presence of opioid receptor antagonists (non-subtype-specific, NTX; kappa-OR-specific, Nor-BNI; and delta-OR-specific, NLD) relative to that without OR blockade. Asterisks – difference from other two groups at p

    Article Snippet: The delta-OR selective antagonist naltrindole hydrochloride (NLD) was purchased from Tocris Biosciences (Minneapolis, MN).

    Techniques:

    Pavlovian inhibitory training produces δ-opioid receptor accumulation on the membrane of NAc-S CINs. (A) Two groups of δ-opioid receptor-eGFP ki mice were given instrumental followed by Pavlovian conditioning. The Pavlovian conditioning

    Journal: British Journal of Pharmacology

    Article Title: δ-Opioid receptors in the accumbens shell mediate the influence of both excitatory and inhibitory predictions on choice

    doi: 10.1111/bph.12731

    Figure Lengend Snippet: Pavlovian inhibitory training produces δ-opioid receptor accumulation on the membrane of NAc-S CINs. (A) Two groups of δ-opioid receptor-eGFP ki mice were given instrumental followed by Pavlovian conditioning. The Pavlovian conditioning

    Article Snippet: The δ-opioid receptor antagonist naltrindole hydrochloride (Tocris Bioscience, Ellisville, MO, USA) was dissolved in 0.9% (w/v) saline containing 5% DMSO to obtain a final concentration of 5 μg·μL−1 .

    Techniques: Mouse Assay

    The influence of inhibitory stimuli on choice between actions requires δ-opioid receptor activation in the NAc-S. (A) During Pavlovian training, rats learned that two stimuli predicted distinct outcomes when they were presented alone, but that

    Journal: British Journal of Pharmacology

    Article Title: δ-Opioid receptors in the accumbens shell mediate the influence of both excitatory and inhibitory predictions on choice

    doi: 10.1111/bph.12731

    Figure Lengend Snippet: The influence of inhibitory stimuli on choice between actions requires δ-opioid receptor activation in the NAc-S. (A) During Pavlovian training, rats learned that two stimuli predicted distinct outcomes when they were presented alone, but that

    Article Snippet: The δ-opioid receptor antagonist naltrindole hydrochloride (Tocris Bioscience, Ellisville, MO, USA) was dissolved in 0.9% (w/v) saline containing 5% DMSO to obtain a final concentration of 5 μg·μL−1 .

    Techniques: Activation Assay

    Exercise pressor reflex and δ-opioid receptors.

    Journal: American Journal of Physiology - Heart and Circulatory Physiology

    Article Title: Peripheral δ-opioid receptors attenuate the exercise pressor reflex

    doi: 10.1152/ajpheart.00116.2013

    Figure Lengend Snippet: Exercise pressor reflex and δ-opioid receptors.

    Article Snippet: In four rats whose left femoral artery had been ligated for 72 h, the highly selective δ-opioid receptor antagonist naltrindole (100 μg, Tocris) was injected with DPDPE (1.0 μg) into the arterial supply of the left hindlimb via the femoral arterial catheter.

    Techniques:

    A : Western blot illustrating results with anti-δ-opioid receptor and anti-actin in DRG tissue isolated from three rats with freely perfused (FP) and ligated (LIG) femoral arteries. Each lane was loaded with ∼25 μg of protein corresponding

    Journal: American Journal of Physiology - Heart and Circulatory Physiology

    Article Title: Peripheral δ-opioid receptors attenuate the exercise pressor reflex

    doi: 10.1152/ajpheart.00116.2013

    Figure Lengend Snippet: A : Western blot illustrating results with anti-δ-opioid receptor and anti-actin in DRG tissue isolated from three rats with freely perfused (FP) and ligated (LIG) femoral arteries. Each lane was loaded with ∼25 μg of protein corresponding

    Article Snippet: In four rats whose left femoral artery had been ligated for 72 h, the highly selective δ-opioid receptor antagonist naltrindole (100 μg, Tocris) was injected with DPDPE (1.0 μg) into the arterial supply of the left hindlimb via the femoral arterial catheter.

    Techniques: Western Blot, Isolation

    Effect of RTX treatment on the δ-opioid receptor binding in the dorsal spinal cord. Comparison of specific [ 3 H]-naltrindole binding to rat dorsal spinal cord membranes from rats treated with vehicle or RTX (n = 4 replicates in each group).

    Journal: Neuropharmacology

    Article Title: Removing TRPV1-expressing Primary Afferent Neurons Potentiates the Spinal Analgesic Effect of ?-Opioid Agonists on Mechano-Nociception

    doi: 10.1016/j.neuropharm.2008.05.011

    Figure Lengend Snippet: Effect of RTX treatment on the δ-opioid receptor binding in the dorsal spinal cord. Comparison of specific [ 3 H]-naltrindole binding to rat dorsal spinal cord membranes from rats treated with vehicle or RTX (n = 4 replicates in each group).

    Article Snippet: Saturation radioligand binding experiments were performed using 200-µl aliquots of tissues and increasing concentrations of [3 H]-naltrindole (35 Ci/mmol, PerkinElmer Life Sciences, Inc., Boston, MA) from 10 to 1,200 pM.

    Techniques: Binding Assay