mrk560 (Tocris)

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Tocris mrk560
Mrk560, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 108 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mrk560/MRK+560/pmc11063690-102-14-15
Average 92 stars, based on 108 article reviews

mrk560 - by Bioz Stars, 2026-09

92/100 stars

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Cleavage Assay:

Article Title: Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells
Article Snippet: .. For GSI assay, PF-3084014, RO4929079, MK-0752, Semagacestat (all purchased from MedChem Express, Monmouth Junction, NJ), BMS-906024 (Maplewood, NJ), MRK560 (Tocris, Minneapolis, MN), BMS299897, DAPT, and {"type":"entrez-nucleotide","attrs":{"text":"LY411575","term_id":"1257853995","term_text":"LY411575"}} LY411575 (Sigma) were tested at the range of 1 p m to 10 μ m . Cell free γ-secretase cleavage assay CHAPSO-solubilized CHO cell, HEK cell membrane, and recombinant γ-secretase substrates rNOTCH1sub, rNOTCH2sub, rNOTCH3sub, rNOTCH4sub, rCD44sub, and rVEGFR1sub were prepared as described in a previous report ( 16 ). .. 25 μg/ml of each substrate was incubated with the membrane (100 μg/ml total protein) in sodium citrate buffer (150 m m , pH 6.5, Roche Complete protease inhibitor added) for 2 h at 37 °C.

Membrane:

Recombinant:

other:

Article Title: Development of a central nervous system axonal myelination assay for high throughput screening
Article Snippet: N -[ N -(3,5-Difluorophenacetyl)- l -alanyl]- S -phenylglycine t-butyl ester (DAPT), LY411,575, and BMS 708163 were from Selleckchem, MRK560 was purchased from Tocris.

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