keap1 (Proteintech)
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Proteintech
keap1
Keap1, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 2075 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/keap1/NRF2%2C+NFE2L2+Antibody/pmc12963995-423-12-17
Average 96 stars, based on 2075 article reviews
Keap1, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 2075 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/keap1/NRF2%2C+NFE2L2+Antibody/pmc12963995-423-12-17
Average 96 stars, based on 2075 article reviews
keap1 - by Bioz Stars,
2026-09
96/100 stars
Images
1) Product Images from "A multimodal ROS logic-gated therapeutic platform disrupts the vicious cycle of senescence to promote aged bone defect repair"
Article Title: A multimodal ROS logic-gated therapeutic platform disrupts the vicious cycle of senescence to promote aged bone defect repair
Journal: Bioactive Materials
doi: 10.1016/j.bioactmat.2026.02.002
Figure Legend Snippet: Transcriptomic and molecular analysis of the potential pathways involved in MMBOx-mediated BMSCs rejuvenation. (A) Circular heatmap showing differentially expressed genes (DEGs) associated with cell senescence, inflammation, and osteogenesis in senescent BMSCs treated with MMBOx@GPP compared to GPP. (B) Gene Ontology (GO) enrichment analysis of upregulated DEGs. (C) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of upregulated DEGs. (D) Gene Set Enrichment Analysis (GSEA) plots of the glutathione metabolic process (ES: enrichment score; NES: normalized enrichment score; FDR: false discovery rate). (E) Heatmap of DEGs enriched in aging-related GO terms. (F) Western blot analysis of Keap1, Nrf2, Nqo1, Gclc, and GAPDH protein expression in BMSCs. (G) Quantitative analysis of protein band intensities ( n = 3). (H) Representative flow cytometry plots of ThiolTracker™ fluorescence staining indicating intracellular glutathione levels. (I) Quantification of intracellular GSH/GSSG ratio in BMSCs ( n = 3). (J) Schematic diagram illustrating the proposed mechanism by which MMBOx attenuates BMSCs senescence via Nrf2 pathway activation and glutathione metabolism enhancement. Data are expressed as mean ± SD; ∗ P < 0.05, ∗∗∗ P < 0.001.
Techniques Used: Western Blot, Expressing, Flow Cytometry, Fluorescence, Staining, Activation Assay
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