iwp2 (Tocris)

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Tocris iwp2
Iwp2, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 591 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/iwp2/IWP+2/pm41963354-273-39-40
Average 96 stars, based on 591 article reviews

iwp2 - by Bioz Stars, 2026-09

96/100 stars

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Cell Culture:

Article Title: Distinct radial glia subtypes regulate midbrain dopaminergic neuron development
Article Snippet: .. For ligand testing, cells were cultured in maturation media(cit) supplemented with WNT5A (100 ng ml −1 ; R&D, 645-WN-010), IWP2 (10 μM; Tocris, 3533), Valsartan (10 μM; Sigma-Aldrich, SML0142), AngII (100 nM; Sigma-Aldrich, A9525), BMP1 (100 ng ml −1 ; R&D, 1927-ZN-010), FGF7 (100 ng ml −1 ; R&D, 251-KG), NBL1 (100 ng ml −1 ; R&D, 755-DA-050), DKK3 (100 ng ml −1 ; R&D, 1118-DK-050) or CGP-42112A (300 nM; Sigma-Aldrich, C160) between days 22 and 35. ..

Article Title: Distinct radial glia subtypes regulate midbrain dopaminergic neuron development.
Article Snippet: .. For ligand testing, cells were cultured in maturation media(cit) supplemented with WNT5A (100 ng ml−1; R&D, 645-WN-010), IWP2 (10 μM; Tocris, 3533), Valsartan (10 μM; Sigma-Aldrich, SML0142), AngII (100 nM; Sigma-Aldrich, A9525), BMP1 (100 ng ml−1; R&D, 1927-ZN-010), FGF7 (100 ng ml−1; R&D, 251-KG), NBL1 (100 ng ml−1; R&D, 755-DA-050), DKK3 (100 ng ml−1; R&D, 1118-DK-050) or CGP-42112A (300 nM; Sigma-Aldrich, C160) between days 22 and 35. ..

other:

Article Title: Protocol for combining BMP, MEK, WNT inhibition and iNGN2 to enable rapid neuronal differentiation and regional patterning from hiPSCs
Article Snippet: IWP2 , Tocris , 3533.

Injection:

Article Title: Reciprocal inhibition of Wnt signaling pathways pattern the interconnection of epithelial tubules in the regenerating zebrafish kidney
Article Snippet: Fish weighed between 0.25 g and 1.0 g. Gentamicin (Sigma Aldrich) diluted in PBS was injected at 80 mg/kg. .. Drug treatments were performed by keeping fish in either 5 μM (IWR1 and IWP2) or 10 μM (PP2 and PP3) or 100 μM (Y-27632) (Tocris) or DMSO (Sigma) dissolved in system water starting at 7 dpi until harvesting kidneys at 8 dpi, except for EHT1864, which was injected intraperitoneally at a dose of 50 mg/kg. ..

Incubation:

Article Title: Unveiling alternate pathways for SARS-CoV-2 infection via extracellular vesicle-mediated transfer of ACE2 and TMPRSS2.
Article Snippet: For induction of anterior foregut endoderm, embryonic bodies were dissociated into single cells using 0.05% Trypsin/EDTA (Thermo Fisher Scientific, 25300120) and plated onto fibronectin-coated six-well tissue culture plates (80,000–105,000 cells/cm2). .. Cells were incubated in SFD medium supplemented with 100 ng/mL human NOGGIN (R&D Systems, 6057-NG/CF) and 10 μM SB431542 (Tocris Bioscience, 1614) for 24 hours followed by switching to SFD media supplemented with 10 μM SB431542 and 1 μM IWP2 (Tocris Bioscience, 3533) for additional 24 hours. .. For induction of early-stage lung progenitor cells (after day 8), at the end of anterior foregut endoderm induction, cells were switched to CFKBRA medium, which consists of SFD media supplemented with 3 μM CHIR99021 (CHIR; Tocris Bioscience, 4423), 10 ng/mL human fibroblast growth factor 10 (FGF10; R&D Systems, 345-FG), 10 ng/mL human keratinocyte growth factor (KGF; R&D Systems, 251-KG/CF), 10 ng/mL human BMP4 and 50 nM all-trans retinoic acid (ATRA; Tocris Bioscience, 0695) for 48 hours to promote the formation of three-dimensional cell clumps.

Concentration Assay:

Article Title: Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications.
Article Snippet: .. 48 h thereafter, IWP2 (Tocris, 3533) was added at a final concentration of 5 μM in fresh RB media. ..

Article Title: Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications
Article Snippet: .. 48 h thereafter, IWP2 (Tocris, 3533) was added at a final concentration of 5 μM in fresh RB media. ..

Review