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Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory <t>Il13</t> and Il4 mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).
Gene Exp Il13 Mm00434204 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory <t>Il13</t> and Il4 mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).
Gene Exp Il13 Rn00587615 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory <t>Il13</t> and Il4 mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).
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Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory <t>Il13</t> and Il4 mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).
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Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory <t>Il13</t> and Il4 mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).
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https://www.bioz.com/result/cyno il13/product/Sino Biological
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Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory <t>Il13</t> and Il4 mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).
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https://www.bioz.com/result/hil 13/product/Sino Biological
Average 94 stars, based on 1 article reviews
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Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory Il13 and Il4 mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).

Journal: bioRxiv

Article Title: Lactate treatment improves brain biochemistry and cognitive function in transgenic Alzheimer’s and wild-type mice

doi: 10.64898/2026.01.28.702254

Figure Lengend Snippet: Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory Il13 and Il4 mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).

Article Snippet: Genes of interest, including Bdnf (Mm01334042_m1), Hcar1 (Mm00558586_s1), Igf1 (Mm00439560_m1), Il1b (Mm00434228_m1), Il4 (Mm00445259_m1), Il13 (Mm00434204_m1), Slc16a7 (Mct2) (Mm00441442_m1), Vegfa (Mm00437306_m1), were assessed.

Techniques: Gene Expression, Quantitative RT-PCR, Standard Deviation