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Image Search Results
Journal: Journal of pharmacological sciences
Article Title: Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation.
doi: 10.1016/j.jphs.2016.11.005
Figure Lengend Snippet: Fig. 1. Upregulation of interleukin-13 receptor a1 (IL-13Ra1) in accumulating macrophages. Mice were subjected to partial sciatic nerve (SCN) ligation (PSL) or sham surgery, and the SCN was collected. The time course of IL-13 (A) and IL-13Ra1 (B) mRNA expression in the injured SCN after PSL was evaluated by RT-qPCR. Data are presented as the mean ± SEM of 5e6 mice. ***P < 0.001 vs sham control. (C) Localization of IL-13Ra1 protein on accumulating F4/80þ macrophages in the injured SCN on day 7 after PSL was visualized by immunohistochemistry. Representative micrographs in longitudinal sections are shown. Scale bars ¼ 20 mm.
Article Snippet: Sections were blocked with 4% bovine serum albumin for 2 h and incubated at 4 C overnight with primary
Techniques: Ligation, Expressing, Quantitative RT-PCR, Control, Immunohistochemistry
Journal: The American Journal of Pathology
Article Title: M2 Polarized Macrophages and Giant Cells Contribute to Myofibrosis in Neuromuscular Sarcoidosis
doi: 10.1016/j.ajpath.2010.11.065
Figure Lengend Snippet: Log10 Relative Quantification (RQ) values of mRNA calibrated against expression of the respective molecules in normal muscle specimens. A: Both of the experimental groups show expression of the common IL-4R, IL-4 is expressed significantly higher in the muscle sarcoidosis group, and IL-13 is exclusively expressed in that group. B: Markers of alternative activation are expressed at a significantly higher level. C: Furthermore, expression of DAP12 is also higher in the muscle sarcoidosis group. *P < 0.05, **P < 0.01, ***P < 0.001.
Article Snippet: The assay identification numbers are as follows: IL-4, Hs00929862_m1; IL-4 receptor (IL-4R), Hs00166237_m1; IL-13,
Techniques: Expressing, Activation Assay