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ovarian cancer igrov1 6 21 non small cell lung cancer nci h23  (ATCC)


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    ATCC ovarian cancer igrov1 6 21 non small cell lung cancer nci h23
    Ovarian Cancer Igrov1 6 21 Non Small Cell Lung Cancer Nci H23, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 936 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/igrov1/NCI-H23/pm23899273__jo401171q_si_001-68-84-120
    Average 96 stars, based on 936 article reviews
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    Related Articles

    Activity Assay:

    Article Title: Design and synthesis of new 2,5-disubstituted-1,3,4-oxadiazole analogues as anticancer agents
    Article Snippet: In continuance of our search for new anticancer agents, we report herein the design, synthesis, and anticancer evaluation of oxadiazole analogues.. Two series (4a-h and 4i-q) of new oxadiazole analogues were designed based on heterocyclic (1,3,4-oxadiazole)-linked aryl core of IMC038525 (tubulin polymerization inhibitor), NSC 776715, and NSC 776715 and synthesized.. All the compounds were fully characterized by infrared, nuclear magnetic resonance spectroscopy, and mass spectral data and the purity of compounds was checked by elemental analysis (C, H, and N analysis).

    Concentration Assay:

    Article Title: Design and synthesis of new 2,5-disubstituted-1,3,4-oxadiazole analogues as anticancer agents
    Article Snippet: In continuance of our search for new anticancer agents, we report herein the design, synthesis, and anticancer evaluation of oxadiazole analogues.. Two series (4a-h and 4i-q) of new oxadiazole analogues were designed based on heterocyclic (1,3,4-oxadiazole)-linked aryl core of IMC038525 (tubulin polymerization inhibitor), NSC 776715, and NSC 776715 and synthesized.. All the compounds were fully characterized by infrared, nuclear magnetic resonance spectroscopy, and mass spectral data and the purity of compounds was checked by elemental analysis (C, H, and N analysis).

    Inhibition:

    Article Title: Design and synthesis of new 2,5-disubstituted-1,3,4-oxadiazole analogues as anticancer agents
    Article Snippet: In continuance of our search for new anticancer agents, we report herein the design, synthesis, and anticancer evaluation of oxadiazole analogues.. Two series (4a-h and 4i-q) of new oxadiazole analogues were designed based on heterocyclic (1,3,4-oxadiazole)-linked aryl core of IMC038525 (tubulin polymerization inhibitor), NSC 776715, and NSC 776715 and synthesized.. All the compounds were fully characterized by infrared, nuclear magnetic resonance spectroscopy, and mass spectral data and the purity of compounds was checked by elemental analysis (C, H, and N analysis).

    Article Title: Synthesis and Anticancer Evaluation of Some Novel Thiophene, Thieno[3,2‐ d ]pyrimidine, Thieno[3,2‐ b ]pyridine, and Thieno[3,2‐ e ][1,4]oxazepine Derivatives Containing Benzothiazole Moiety
    Article Snippet: In an attempt to establish novel candidate with promising anticancer activity, two derivatives of (benzo[d] thiazol-2-yl)thiophene backbone 1 and 14 were synthesized, and they further reacted with various chemical reagents to afford the corresponding substituted thiophene derivatives 6, 8, 10, 15, 17, and 20, thieno[3,2-d] pyrimidine derivatives 2–5, 7, 9, 16, 21, 23, and 24, thieno[3,2-b]pyridine derivatives 11–13, and thieno[3,2e][1,4]oxazepine derivative 18.. Structures of prepared compounds were affirmed via spectral and elemental data.. Among the obtained compounds, seven derivatives 2, 3, 4, 5, 11, 12, and 13 were chosen by National Cancer Institute, USA.

    Multiple Displacement Amplification:

    Article Title: Design and synthesis of new 2,5-disubstituted-1,3,4-oxadiazole analogues as anticancer agents
    Article Snippet: In continuance of our search for new anticancer agents, we report herein the design, synthesis, and anticancer evaluation of oxadiazole analogues.. Two series (4a-h and 4i-q) of new oxadiazole analogues were designed based on heterocyclic (1,3,4-oxadiazole)-linked aryl core of IMC038525 (tubulin polymerization inhibitor), NSC 776715, and NSC 776715 and synthesized.. All the compounds were fully characterized by infrared, nuclear magnetic resonance spectroscopy, and mass spectral data and the purity of compounds was checked by elemental analysis (C, H, and N analysis).

    Article Title: A profile of 8-oxo-dGTPase activities in the NCI-60 human cancer panel: Meta-analytic insight into the regulation and role of MTH1 (NUDT1) gene expression in carcinogenesis.
    Article Snippet: .. For this purpose all available MTH1 z-scores (12 in most cases) for the 59 cell lines have been averaged, giving the following integrated MTH1 expression z-scores: CCRF-CEM: 2.9893, HL-60(TB): 0.8178, K-562: -0.7434, MOLT-4: -0.2775, RPMI-8226: -0.1419, SR: 0.2248, A549/ATCC: 0.2715, EKVX: 0.2858, HOP-62: -0.6308, HOP-92: -0.1013, NCI-H226: -0.6528, NCI-H23: 1.9629, NCI-H322M: 1.4084, NCI-H460: 0.0792, NCI-H522: -0.2483, COLO205: 0.6650, HCC-2998: -0.0060, HCT-116: -0.7296, HCT-15: -0.9233, HT29: -0.3817, KM12: -0.3473, SW-620: -0.2189, SF-268: 0.5170, SF-295: 0.8383, SF-539: 0.5031, SNB-19: 0.8208, SNB-75: -0.4071, U251: 2.2282, LOXIMVI: -0.1532, MALME-3M: 0.4383, M14: -0.2538, MDA-MB-435: -0.5973, SK-MEL-2: 0.1932, SK-MEL-28: 0.2586, SK-MEL-5: 0.9284, UACC-257: -0.1012, UACC-62: -0.1453, IGROV1: -0.2279, OVCAR-3: -0.7268, OVCAR-4: -0.6395, OVCAR-5: -0.4953, OVCAR-8: -0.7403, NCI/ADR-RES: -0.5704, SK-OV-3: -1.0567, 786-0: -0.1274, A498: 0.2676, ACHN: -0.1841, CAKI-1: -0.7590, RXF393: 0.5003, SN12C: -0.0680, TK-10: -0.8080, UO-31: -0.5808, PC-3: -0.7493, DU-145: -0.5330, MCF7: 0.6019, MDA-MB-231/ATCC: -0.5648, HS578T: -0.3195, BT-549: -0.1946, T-47D: -0.2739. .. As Figure 6 makes clear, the individual MTH1 profiles are highly correlated with the integrated one and the calculated Pearson correlation coefficients are much higher than their respective MPCC values (Agilent: r = 0.926, p = 8.5e-26; Genelogic U95: r = 0.903, p = 1.3e-22; Novartis U95: r = 0.869, p = 4.6e-19; U133 Plus 2.0: r = 0.867, p = 6.8e-19; HuEx 1.0 ST exon 4: r = 0.842, p = 1.3e-16; Genelogic U133: r = 0.789, p = 1.1e-13; Applied Genomics: r = 0.777, p = 1.9e-12; Chiron U133: r = 0.729, p = 9.0e-11; 8-oxo-dGTPase activity: r = 0.725, p = 8.4e-11; IDIS: r = 0.636; p = 8.3e-8; Millennium: r = 0.630, p = 9.1e-8; BI Hu6800: r = 0.617, p = 2.0e-7).

    other:


    Article Title: Protein Paucimannosylation Is an Enriched N-Glycosylation Signature of Human Cancers.
    Article Snippet: IGROV1 (ATCC TCP- 1021) iii.

    Article Title: Trends in oligomannosylation and α1,2-mannosidase expression in human cancers
    Article Snippet: IGROV1 (ATCC TCP-1021) iii.

    Expressing:

    Article Title: A profile of 8-oxo-dGTPase activities in the NCI-60 human cancer panel: Meta-analytic insight into the regulation and role of MTH1 (NUDT1) gene expression in carcinogenesis.
    Article Snippet: .. For this purpose all available MTH1 z-scores (12 in most cases) for the 59 cell lines have been averaged, giving the following integrated MTH1 expression z-scores: CCRF-CEM: 2.9893, HL-60(TB): 0.8178, K-562: -0.7434, MOLT-4: -0.2775, RPMI-8226: -0.1419, SR: 0.2248, A549/ATCC: 0.2715, EKVX: 0.2858, HOP-62: -0.6308, HOP-92: -0.1013, NCI-H226: -0.6528, NCI-H23: 1.9629, NCI-H322M: 1.4084, NCI-H460: 0.0792, NCI-H522: -0.2483, COLO205: 0.6650, HCC-2998: -0.0060, HCT-116: -0.7296, HCT-15: -0.9233, HT29: -0.3817, KM12: -0.3473, SW-620: -0.2189, SF-268: 0.5170, SF-295: 0.8383, SF-539: 0.5031, SNB-19: 0.8208, SNB-75: -0.4071, U251: 2.2282, LOXIMVI: -0.1532, MALME-3M: 0.4383, M14: -0.2538, MDA-MB-435: -0.5973, SK-MEL-2: 0.1932, SK-MEL-28: 0.2586, SK-MEL-5: 0.9284, UACC-257: -0.1012, UACC-62: -0.1453, IGROV1: -0.2279, OVCAR-3: -0.7268, OVCAR-4: -0.6395, OVCAR-5: -0.4953, OVCAR-8: -0.7403, NCI/ADR-RES: -0.5704, SK-OV-3: -1.0567, 786-0: -0.1274, A498: 0.2676, ACHN: -0.1841, CAKI-1: -0.7590, RXF393: 0.5003, SN12C: -0.0680, TK-10: -0.8080, UO-31: -0.5808, PC-3: -0.7493, DU-145: -0.5330, MCF7: 0.6019, MDA-MB-231/ATCC: -0.5648, HS578T: -0.3195, BT-549: -0.1946, T-47D: -0.2739. .. As Figure 6 makes clear, the individual MTH1 profiles are highly correlated with the integrated one and the calculated Pearson correlation coefficients are much higher than their respective MPCC values (Agilent: r = 0.926, p = 8.5e-26; Genelogic U95: r = 0.903, p = 1.3e-22; Novartis U95: r = 0.869, p = 4.6e-19; U133 Plus 2.0: r = 0.867, p = 6.8e-19; HuEx 1.0 ST exon 4: r = 0.842, p = 1.3e-16; Genelogic U133: r = 0.789, p = 1.1e-13; Applied Genomics: r = 0.777, p = 1.9e-12; Chiron U133: r = 0.729, p = 9.0e-11; 8-oxo-dGTPase activity: r = 0.725, p = 8.4e-11; IDIS: r = 0.636; p = 8.3e-8; Millennium: r = 0.630, p = 9.1e-8; BI Hu6800: r = 0.617, p = 2.0e-7).



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    Image Search Results


    In vitro growth inhibition% (GI%) of NCI 60 cancer cell line panel after treatment with 10 μM of the oxindole–benzothiazoles 9a – c and 9e-r

    Journal: BMC Chemistry

    Article Title: Oxindole–benzothiazole hybrids as CDK2 inhibitors and anticancer agents: design, synthesis and biological evaluation

    doi: 10.1186/s13065-024-01277-1

    Figure Lengend Snippet: In vitro growth inhibition% (GI%) of NCI 60 cancer cell line panel after treatment with 10 μM of the oxindole–benzothiazoles 9a – c and 9e-r

    Article Snippet: A549/ATCC , 30.9 , IGROV1 , 2.22.

    Techniques: In Vitro, Inhibition

    GI 50 (µM) of oxindole – benzothiazole hybrid 9o on NCI cancer cell lines

    Journal: BMC Chemistry

    Article Title: Oxindole–benzothiazole hybrids as CDK2 inhibitors and anticancer agents: design, synthesis and biological evaluation

    doi: 10.1186/s13065-024-01277-1

    Figure Lengend Snippet: GI 50 (µM) of oxindole – benzothiazole hybrid 9o on NCI cancer cell lines

    Article Snippet: A549/ATCC , 30.9 , IGROV1 , 2.22.

    Techniques: