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extruder set without holder/heating block  (Avanti Polar)
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Avanti Polar extruder set without holder/heating block
Extruder Set Without Holder/Heating Block, supplied by Avanti Polar, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/heat/Extruder+Set+Without+Holder%2FHeating+Block/custom%40610023-1ea%4042461224
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extruder set without holder/heating block - by Bioz Stars, 2026-10
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heat shock response activator hsf1a  (MedChemExpress)
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MedChemExpress heat shock response activator hsf1a
Pharmacological modulation of Hsp70 alters cell viability and reveals divergent MAPK1 transcriptional responses in SACC-83 and SACC-LM cells. (A) Cell viability of SACC-83 and SACC-LM cells treated with VER155008 at 0, 10, 20, and 40 μM, as determined by CCK-8 assay. (B) Positive cell ratio of SACC-83 and SACC-LM cells treated with <t>HSF1A</t> at 0, 200, 500, 1000, and 1500 nM, as determined by CCK-8 assay. (C) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-83 cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (D) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-LM cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (E) Representative Western blot images showing Hsp70 protein expression in SACC-83 cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (F) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-83 cells following VER155008 (left) and HSF1A (right) treatment. (G) Representative Western blot images showing Hsp70 protein expression in SACC-LM cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (H) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-LM cells following VER155008 (left) and HSF1A (right) treatment. Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
Heat Shock Response Activator Hsf1a, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 99 stars, based on 1 article reviews
heat shock response activator hsf1a - by Bioz Stars, 2026-10
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heat shock proteins  (Millipore)
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Millipore heat shock proteins
Pharmacological modulation of Hsp70 alters cell viability and reveals divergent MAPK1 transcriptional responses in SACC-83 and SACC-LM cells. (A) Cell viability of SACC-83 and SACC-LM cells treated with VER155008 at 0, 10, 20, and 40 μM, as determined by CCK-8 assay. (B) Positive cell ratio of SACC-83 and SACC-LM cells treated with <t>HSF1A</t> at 0, 200, 500, 1000, and 1500 nM, as determined by CCK-8 assay. (C) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-83 cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (D) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-LM cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (E) Representative Western blot images showing Hsp70 protein expression in SACC-83 cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (F) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-83 cells following VER155008 (left) and HSF1A (right) treatment. (G) Representative Western blot images showing Hsp70 protein expression in SACC-LM cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (H) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-LM cells following VER155008 (left) and HSF1A (right) treatment. Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
Heat Shock Proteins, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/heat/anti+hsp90/nct00704626-3-9-12
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heat shock proteins - by Bioz Stars, 2026-10
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heat labile udg enzyme  (New England Biolabs)
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New England Biolabs heat labile udg enzyme
Pharmacological modulation of Hsp70 alters cell viability and reveals divergent MAPK1 transcriptional responses in SACC-83 and SACC-LM cells. (A) Cell viability of SACC-83 and SACC-LM cells treated with VER155008 at 0, 10, 20, and 40 μM, as determined by CCK-8 assay. (B) Positive cell ratio of SACC-83 and SACC-LM cells treated with <t>HSF1A</t> at 0, 200, 500, 1000, and 1500 nM, as determined by CCK-8 assay. (C) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-83 cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (D) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-LM cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (E) Representative Western blot images showing Hsp70 protein expression in SACC-83 cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (F) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-83 cells following VER155008 (left) and HSF1A (right) treatment. (G) Representative Western blot images showing Hsp70 protein expression in SACC-LM cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (H) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-LM cells following VER155008 (left) and HSF1A (right) treatment. Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
Heat Labile Udg Enzyme, supplied by New England Biolabs, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 99 stars, based on 1 article reviews
heat labile udg enzyme - by Bioz Stars, 2026-10
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temperature controlled heating  (Warner Instruments)
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Warner Instruments temperature controlled heating
Pharmacological modulation of Hsp70 alters cell viability and reveals divergent MAPK1 transcriptional responses in SACC-83 and SACC-LM cells. (A) Cell viability of SACC-83 and SACC-LM cells treated with VER155008 at 0, 10, 20, and 40 μM, as determined by CCK-8 assay. (B) Positive cell ratio of SACC-83 and SACC-LM cells treated with <t>HSF1A</t> at 0, 200, 500, 1000, and 1500 nM, as determined by CCK-8 assay. (C) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-83 cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (D) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-LM cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (E) Representative Western blot images showing Hsp70 protein expression in SACC-83 cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (F) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-83 cells following VER155008 (left) and HSF1A (right) treatment. (G) Representative Western blot images showing Hsp70 protein expression in SACC-LM cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (H) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-LM cells following VER155008 (left) and HSF1A (right) treatment. Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
Temperature Controlled Heating, supplied by Warner Instruments, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/heat/controller+temperature/pmc13054578-138-6-14
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rodent  (Stoelting inc)
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Pharmacological modulation of Hsp70 alters cell viability and reveals divergent MAPK1 transcriptional responses in SACC-83 and SACC-LM cells. (A) Cell viability of SACC-83 and SACC-LM cells treated with VER155008 at 0, 10, 20, and 40 μM, as determined by CCK-8 assay. (B) Positive cell ratio of SACC-83 and SACC-LM cells treated with <t>HSF1A</t> at 0, 200, 500, 1000, and 1500 nM, as determined by CCK-8 assay. (C) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-83 cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (D) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-LM cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (E) Representative Western blot images showing Hsp70 protein expression in SACC-83 cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (F) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-83 cells following VER155008 (left) and HSF1A (right) treatment. (G) Representative Western blot images showing Hsp70 protein expression in SACC-LM cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (H) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-LM cells following VER155008 (left) and HSF1A (right) treatment. Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
Rodent, supplied by Stoelting inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/heat/Stoelting+Rodent+Warmer+X1+with+Mouse+Heating+Pad/10__1523_slash_eneuro__0123___26__2026-68-25-28
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rodent - by Bioz Stars, 2026-10
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ika rct basic magnetic stirrer  (Darwin Microfluidics)
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Darwin Microfluidics ika rct basic magnetic stirrer
Pharmacological modulation of Hsp70 alters cell viability and reveals divergent MAPK1 transcriptional responses in SACC-83 and SACC-LM cells. (A) Cell viability of SACC-83 and SACC-LM cells treated with VER155008 at 0, 10, 20, and 40 μM, as determined by CCK-8 assay. (B) Positive cell ratio of SACC-83 and SACC-LM cells treated with <t>HSF1A</t> at 0, 200, 500, 1000, and 1500 nM, as determined by CCK-8 assay. (C) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-83 cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (D) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-LM cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (E) Representative Western blot images showing Hsp70 protein expression in SACC-83 cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (F) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-83 cells following VER155008 (left) and HSF1A (right) treatment. (G) Representative Western blot images showing Hsp70 protein expression in SACC-LM cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (H) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-LM cells following VER155008 (left) and HSF1A (right) treatment. Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
Ika Rct Basic Magnetic Stirrer, supplied by Darwin Microfluidics, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/heat/IKA+RCT+basic+Magnetic+Stirrer/custom%40ik-0025005927%4042508926
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ika rct basic magnetic stirrer - by Bioz Stars, 2026-10
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heating pad  (Stoelting inc)
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Stoelting inc heating pad
Pharmacological modulation of Hsp70 alters cell viability and reveals divergent MAPK1 transcriptional responses in SACC-83 and SACC-LM cells. (A) Cell viability of SACC-83 and SACC-LM cells treated with VER155008 at 0, 10, 20, and 40 μM, as determined by CCK-8 assay. (B) Positive cell ratio of SACC-83 and SACC-LM cells treated with <t>HSF1A</t> at 0, 200, 500, 1000, and 1500 nM, as determined by CCK-8 assay. (C) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-83 cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (D) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-LM cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (E) Representative Western blot images showing Hsp70 protein expression in SACC-83 cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (F) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-83 cells following VER155008 (left) and HSF1A (right) treatment. (G) Representative Western blot images showing Hsp70 protein expression in SACC-LM cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (H) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-LM cells following VER155008 (left) and HSF1A (right) treatment. Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
Heating Pad, supplied by Stoelting inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/heat/Mouse+Heating+Pad/pmc13406893-84-15-23
Average 94 stars, based on 1 article reviews
heating pad - by Bioz Stars, 2026-10
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extruder set with holder/heating block  (Avanti Polar)
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Avanti Polar extruder set with holder/heating block
Pharmacological modulation of Hsp70 alters cell viability and reveals divergent MAPK1 transcriptional responses in SACC-83 and SACC-LM cells. (A) Cell viability of SACC-83 and SACC-LM cells treated with VER155008 at 0, 10, 20, and 40 μM, as determined by CCK-8 assay. (B) Positive cell ratio of SACC-83 and SACC-LM cells treated with <t>HSF1A</t> at 0, 200, 500, 1000, and 1500 nM, as determined by CCK-8 assay. (C) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-83 cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (D) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-LM cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (E) Representative Western blot images showing Hsp70 protein expression in SACC-83 cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (F) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-83 cells following VER155008 (left) and HSF1A (right) treatment. (G) Representative Western blot images showing Hsp70 protein expression in SACC-LM cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (H) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-LM cells following VER155008 (left) and HSF1A (right) treatment. Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
Extruder Set With Holder/Heating Block, supplied by Avanti Polar, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/heat/Extruder+Set+With+Holder%2FHeating+Block/custom%40610000-1ea%4042081616
Average 91 stars, based on 1 article reviews
extruder set with holder/heating block - by Bioz Stars, 2026-10
91/100 stars
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rodent warmer 53800 m  (Stoelting inc)
94
Stoelting inc rodent warmer 53800 m
Pharmacological modulation of Hsp70 alters cell viability and reveals divergent MAPK1 transcriptional responses in SACC-83 and SACC-LM cells. (A) Cell viability of SACC-83 and SACC-LM cells treated with VER155008 at 0, 10, 20, and 40 μM, as determined by CCK-8 assay. (B) Positive cell ratio of SACC-83 and SACC-LM cells treated with <t>HSF1A</t> at 0, 200, 500, 1000, and 1500 nM, as determined by CCK-8 assay. (C) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-83 cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (D) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-LM cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (E) Representative Western blot images showing Hsp70 protein expression in SACC-83 cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (F) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-83 cells following VER155008 (left) and HSF1A (right) treatment. (G) Representative Western blot images showing Hsp70 protein expression in SACC-LM cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (H) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-LM cells following VER155008 (left) and HSF1A (right) treatment. Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
Rodent Warmer 53800 M, supplied by Stoelting inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/heat/Stoelting+Rodent+Warmer+X1+with+Mouse+Heating+Pad/bio_rxiv__64898__2026__06__29__735190-135-25-29
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rodent warmer 53800 m - by Bioz Stars, 2026-10
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Image Search Results


Pharmacological modulation of Hsp70 alters cell viability and reveals divergent MAPK1 transcriptional responses in SACC-83 and SACC-LM cells. (A) Cell viability of SACC-83 and SACC-LM cells treated with VER155008 at 0, 10, 20, and 40 μM, as determined by CCK-8 assay. (B) Positive cell ratio of SACC-83 and SACC-LM cells treated with HSF1A at 0, 200, 500, 1000, and 1500 nM, as determined by CCK-8 assay. (C) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-83 cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (D) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-LM cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (E) Representative Western blot images showing Hsp70 protein expression in SACC-83 cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (F) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-83 cells following VER155008 (left) and HSF1A (right) treatment. (G) Representative Western blot images showing Hsp70 protein expression in SACC-LM cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (H) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-LM cells following VER155008 (left) and HSF1A (right) treatment. Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

Journal: Frontiers in Oncology

Article Title: CFTR functions as a tumor suppressor in adenoid cystic carcinoma and its silencing reveals an associated vulnerability involving the Hsp70 chaperone system

doi: 10.3389/fonc.2026.1836263

Figure Lengend Snippet: Pharmacological modulation of Hsp70 alters cell viability and reveals divergent MAPK1 transcriptional responses in SACC-83 and SACC-LM cells. (A) Cell viability of SACC-83 and SACC-LM cells treated with VER155008 at 0, 10, 20, and 40 μM, as determined by CCK-8 assay. (B) Positive cell ratio of SACC-83 and SACC-LM cells treated with HSF1A at 0, 200, 500, 1000, and 1500 nM, as determined by CCK-8 assay. (C) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-83 cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (D) RT-qPCR analysis of MAPK1 and HSPA1A mRNA expression in SACC-LM cells following VER155008 treatment (left, middle) and HSPA1A expression following HSF1A treatment (right). (E) Representative Western blot images showing Hsp70 protein expression in SACC-83 cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (F) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-83 cells following VER155008 (left) and HSF1A (right) treatment. (G) Representative Western blot images showing Hsp70 protein expression in SACC-LM cells treated with VER155008 or HSF1A, with GAPDH as the loading control. (H) Densitometric quantification of Hsp70 protein levels normalized to GAPDH in SACC-LM cells following VER155008 (left) and HSF1A (right) treatment. Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

Article Snippet: The functional impact of Hsp70 modulation was assessed using the inhibitor VER155008 (MedChemExpress, HY10941) and the heat shock response activator HSF1A (MedChemExpress, HY103000 ).

Techniques: CCK-8 Assay, Quantitative RT-PCR, Expressing, Western Blot, Control

Pharmacological modulation of Hsp70 alters the migration and invasion capacities of SACC-83 and SACC-LM cells. (A, B) Wound-healing assays evaluating the migration of SACC-83 (A) and SACC-LM (B) cells following VER155008 treatment. (C, D) Wound-healing assays evaluating the migration of SACC-83 (C) and SACC-LM (D) cells following HSF1A treatment. (E, F) Transwell invasion assays assessing the invasive capacity of SACC-83 (E) and SACC-LM (F) cells treated with VER155008. (G, H) Transwell invasion assays assessing the invasive capacity of SACC-83 (G) and SACC-LM (H) cells treated with HSF1A. Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

Journal: Frontiers in Oncology

Article Title: CFTR functions as a tumor suppressor in adenoid cystic carcinoma and its silencing reveals an associated vulnerability involving the Hsp70 chaperone system

doi: 10.3389/fonc.2026.1836263

Figure Lengend Snippet: Pharmacological modulation of Hsp70 alters the migration and invasion capacities of SACC-83 and SACC-LM cells. (A, B) Wound-healing assays evaluating the migration of SACC-83 (A) and SACC-LM (B) cells following VER155008 treatment. (C, D) Wound-healing assays evaluating the migration of SACC-83 (C) and SACC-LM (D) cells following HSF1A treatment. (E, F) Transwell invasion assays assessing the invasive capacity of SACC-83 (E) and SACC-LM (F) cells treated with VER155008. (G, H) Transwell invasion assays assessing the invasive capacity of SACC-83 (G) and SACC-LM (H) cells treated with HSF1A. Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

Article Snippet: The functional impact of Hsp70 modulation was assessed using the inhibitor VER155008 (MedChemExpress, HY10941) and the heat shock response activator HSF1A (MedChemExpress, HY103000 ).

Techniques: Migration

Pharmacological and genetic modulation of Hsp70 modulates the proliferation and apoptosis of SACC-83 and SACC-LM cells. (A, B) CCK-8 assays evaluating the proliferation of SACC-83 cells following VER155008 (A) or HSF1A (B) treatment. (C, D) CCK-8 assays evaluating the proliferation of SACC-83 cells with Hsp70 knockdown (C) or overexpression (D) combined with VER155008 treatment. (E, F) CCK-8 assays evaluating the proliferation of SACC-LM cells following VER155008 (E) or HSF1A (F) treatment. (G, H) CCK-8 assays evaluating the proliferation of SACC-LM cells with Hsp70 knockdown (G) or overexpression (H) combined with VER155008 treatment. (I, J) Flow cytometry analysis of apoptosis in SACC-83 cells treated with VER155008 (I) or HSF1A (J) . (K, L) Flow cytometry analysis of apoptosis in SACC-LM cells treated with VER155008 (K) or HSF1A (L) . Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, ****P < 0.0001.

Journal: Frontiers in Oncology

Article Title: CFTR functions as a tumor suppressor in adenoid cystic carcinoma and its silencing reveals an associated vulnerability involving the Hsp70 chaperone system

doi: 10.3389/fonc.2026.1836263

Figure Lengend Snippet: Pharmacological and genetic modulation of Hsp70 modulates the proliferation and apoptosis of SACC-83 and SACC-LM cells. (A, B) CCK-8 assays evaluating the proliferation of SACC-83 cells following VER155008 (A) or HSF1A (B) treatment. (C, D) CCK-8 assays evaluating the proliferation of SACC-83 cells with Hsp70 knockdown (C) or overexpression (D) combined with VER155008 treatment. (E, F) CCK-8 assays evaluating the proliferation of SACC-LM cells following VER155008 (E) or HSF1A (F) treatment. (G, H) CCK-8 assays evaluating the proliferation of SACC-LM cells with Hsp70 knockdown (G) or overexpression (H) combined with VER155008 treatment. (I, J) Flow cytometry analysis of apoptosis in SACC-83 cells treated with VER155008 (I) or HSF1A (J) . (K, L) Flow cytometry analysis of apoptosis in SACC-LM cells treated with VER155008 (K) or HSF1A (L) . Data are presented as mean ± SD from n = 3 independent biological experiments. *P < 0.05, ****P < 0.0001.

Article Snippet: The functional impact of Hsp70 modulation was assessed using the inhibitor VER155008 (MedChemExpress, HY10941) and the heat shock response activator HSF1A (MedChemExpress, HY103000 ).

Techniques: CCK-8 Assay, Knockdown, Over Expression, Flow Cytometry