grap (Proteintech)
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93
Structured Review
Proteintech
grap
Grap, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/grap/product/Proteintech
Average 93 stars, based on 2 article reviews
Grap, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/grap/product/Proteintech
Average 93 stars, based on 2 article reviews
grap - by Bioz Stars,
2026-03
93/100 stars
Images
1) Product Images from "Identification of tumor associated neutrophils-related genes in triple-negative breast cancer for predicting prognosis and therapeutic response through integrated single-cell analysis"
Article Title: Identification of tumor associated neutrophils-related genes in triple-negative breast cancer for predicting prognosis and therapeutic response through integrated single-cell analysis
Journal: Frontiers in Immunology
doi: 10.3389/fimmu.2025.1613529
Figure Legend Snippet: Identification of candidate genes. (A) Differences in survival between the high and low neutrophil group. (B) RSF analysis and expression levels of genes related to prognosis. (C) Expression levels and distributions of RASGRP4, COX20, CD47, TIMM10B, LY86, GRAP, TNFRSF13C and ATP6V0D1 in different tumor subtypes. (D-G) Kaplan–Meier graphs displaying the survival potential of patients with TNBC, grouped by the expression levels of significant genes.
Techniques Used: Expressing
Figure Legend Snippet: Correlations between TIMM10B, GRAP, TNFRSF13C and RASGRP4 and drug sensitivity. (A-D) Correlations between key genes and the IC50 of chemotherapeutic agents.
Techniques Used:
Figure Legend Snippet: GSEA and GSVA of the four genes. (A-D) . GSEA revealed the enriched signaling pathways associated with TIMM10B, GRAP, TNFRSF13C and RASGRP4. (E-H) . Analysis of key genes using GSVA. The x-axis illustrates the t value of the GSVA score, and the y-axis depicts KEGG pathways; blue highlights upregulated pathways, whereas green highlights downregulated pathways. |NES| ≥ 1 and FDR < 0.25.
Techniques Used: Protein-Protein interactions
Figure Legend Snippet: Cell communication and quasitemporal analysis. (A) Circus plot illustrating the greater total number of significantly interacting pairs between neutrophils and immune cells as estimated by CellPhoneDB (P<0.05). (B) Bubble diagram of the cell communication network between ligands and neutrophils and other cell subtypes as well as with neutrophil itself themselves. (C-E) Trajectory analysis of the potential relatedness between the two groups according to pseudotime, cell type and group. (F-H) Changes in the expression of TIMM10B, GRAP, TNFRSF13C and RASGRP4 over pseudotime.
Techniques Used: Expressing
Figure Legend Snippet: Clinical relevance of TIMM10B, GRAP, TNFRSF13C and RASGRP4. (A) Polychromatic immunofluorescence staining showing the distribution of MPO, TIMM10B, GRAP, TNFRSF13C and RASGRP4 expression. Scale bar (upper panel), 200 µm. Scale bar (bottom panel), 50 µm. (B) IHC scores of MPO, TIMM10B, GRAP, TNFRSF13C and RASGRP4 in adjacent tissue (AT), stage I-II (I-II) and III TNBC. (C) Correlations between MPO and the four candidate genes in stage I-II (I-II) TNBC. (D) Correlations between MPO and the four candidate genes in stage III (III) TNBC. (E) Representative images of coimmunostaining for MPO and four target genes in adjacent tissue from the stage I-II and III TNBC groups. Scale bar, 20 µm. (F) Percentage of TIMM10B-, GRAP-, TNFRSF13C- and RASGRP4-positive cells in AT and stage I-II and III TNBC. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ns, not significant.
Techniques Used: Immunofluorescence, Staining, Expressing