geldoc (Syngene)
86
Structured Review
Syngene
geldoc
Geldoc, supplied by Syngene, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/geldoc/documentation+gel+genius+system/pmc13127080-61-5-6
Average 86 stars, based on 1 article reviews
Geldoc, supplied by Syngene, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/geldoc/documentation+gel+genius+system/pmc13127080-61-5-6
Average 86 stars, based on 1 article reviews
geldoc - by Bioz Stars,
2026-10
86/100 stars
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other:Article Title: Folic acid modified cationic γ-cyclodextrin-oligoethylenimine star polymer with bioreducible disulfide linker for efficient targeted gene delivery. Article Snippet: For an efficient folate-targeted delivery, while the interaction between the folate on the carriers and the folate receptor (FR) on the cells is necessary, the recovering and recycling of FR to maintain a high density level of FR on the cellular membrane is also important.. Herein, we demonstrate a design and synthesis of a new starshaped cationic polymer containing a γ-cyclodextrin (γ-CD) core and multiple oligoethylenimine (OEI) arms with folic acid (FA) linked by a bioreducible disulfide bond for efficient targeted gene delivery.. The newly synthesized cationic polymer, named γ-CD-OEI-SS-FA, could be cleaved efficiently, and FA was readily released under reductive condition similar to intracellular environment. Article Title: Supramolecular anchoring of DNA polyplexes in cyclodextrin-based polypseudorotaxane hydrogels for sustained gene delivery. Article Snippet: A cyclodextrin-based supramolecular hydrogel system with supramolecularly anchored active cationic copolymer/plasmid DNA (pDNA) polyplexes was studied as a sustained gene delivery carrier.. A few biodegradable triblock copolymers of methoxy-poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly[2-(dimethylamino)ethyl methacrylate] (MPEG-PCLPDMAEMA) with well-defined cationic block lengths were prepared to condense pDNA.. The MPEG-PCL-PDMAEMA copolymers exhibit good ability to condense pDNA into 275−405 nm polyplexes with hydrophilic MPEG in the outer corona. Article Title: Preparation and Characterization of Folate-Targeted Fe3O4 Nanoparticle Codelivering Cisplatin and TFPI-2 Plasmid DNA for Nasopharyngeal Carcinoma Therapy Article Snippet: Visualization and photograph capture were accomplished by UV light box using GelDoc system (Synoptics Ltd., UK). Article Title: Chitosan-graft-(PEI-β-cyclodextrin) copolymers and their supramolecular PEGylation for DNA and siRNA delivery. Article Snippet: Two water-soluble chitosan-graft-(polyethylenimine-b-cyclodextrin) (CPC) cationic copolymers were synthesized via reductive amination between oxidized chitosan (CTS) and low molecular weight polyethylenimine-modified b-cyclodextrin (b-CD-PEI).. The two polycations, termed as CPC1 and CPC2, were characterized by proton nuclear magnetic resonance spectroscopy, gel permeation chromatography, and elemental analysis.. These polycations exhibited good ability to condense both plasmid DNA (pDNA) and small interfering RNA (siRNA) into compact and spherical nanoparticles. Article Title: FGFR-targeted gene delivery mediated by supramolecular assembly between β-cyclodextrin-crosslinked PEI and redox-sensitive PEG. Article Snippet: A new redox-sensitive poly(ethylene glycol) (PEG)-based gene vector specially designed to target fibroblast growth factor receptors (FGFRs) was developed by host-guest supramolecular complexation.. The new vector was designed as follows: 1) A host segment was consisted of b-cyclodextrin-crosslinked low molecular polyethylenimine (PEI) conjugated with MC11 peptide (MQLPLATGGGC) that can target FGFRs, being termed as MC11-PEI-b-cyclodextrin (MPC); 2) A guest segment is consisted of PEG and adamantyl group linked by a disulfide bond, the adamantyl-SS-PEG (Ad-SS-PEG); and 3) PEGylation of MPC by supramolecular complexation between MPC and Ad-SS-PEG to generate MPC/Ad-SSPEG polycation, where the PEG chains can stabilize the DNA polyplexes extracellularly but can be readily cleavable intracellularly.. It was found that the MPC/Ad-SS-PEG complexes could efficiently condense pDNA into nanoparticles around 100e200 nm, and were able to effectively stabilize polyplexes against saltor BSA-induced aggregation. Nucleic Acid Electrophoresis:Article Title: Folate-Targeted Nanocarriers Co-Deliver Ganciclovir and miR-34a-5p for Combined Anti-KSHV Therapy Article Snippet: .. Secondly, gel electrophoresis was conducted using a TAE buffer at 110 V for 20 min in a sub-cell system (Bio-Rad Laboratories, Hercules, CA, USA). miR-34a-5p bands were visualized using a UV lamp with a Article Title: Nonviral DNA Delivery System with Supramolecular PEGylation Formed by Host-Guest Pseudo-Block Copolymers. Article Snippet: A cationic supramolecular system based on host−guest pseudoblock copolymers was developed for nonviral DNA delivery.. In this system, the macromolecular host was a cationic star-shaped polymer composed of a β-cyclodextrin (β-CD) core and multiple poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) chains grafted on the core, while the macromolecular guest was a linear adamantyl-ended poly(ethylene glycol) (mPEG-Ad).. Pseudoblock copolymers were self-assembled from the polymeric host−guest pairs (typically, 1:1 molar ratio) in aqueous media through the inclusion of an adamantyl group at the end of guest polymer into the β-CD cavity of host polymers. |