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recombinant human gdf-7  (PeproTech)


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    Structured Review

    PeproTech recombinant human gdf-7
    KEY RESOURCES TABLE
    Recombinant Human Gdf 7, supplied by PeproTech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/recombinant human gdf-7/product/PeproTech
    Average 90 stars, based on 1 article reviews
    recombinant human gdf-7 - by Bioz Stars, 2026-06
    90/100 stars

    Images

    1) Product Images from "Directed differentiation of human iPSCs into mesenchymal lineages by optogenetic control of TGF-β signaling"

    Article Title: Directed differentiation of human iPSCs into mesenchymal lineages by optogenetic control of TGF-β signaling

    Journal: Cell reports

    doi: 10.1016/j.celrep.2023.112509

    KEY RESOURCES TABLE
    Figure Legend Snippet: KEY RESOURCES TABLE

    Techniques Used: Affinity Purification, Virus, Recombinant, Protease Inhibitor, SYBR Green Assay, Solvent, Plasmid Preparation, Control, Functional Assay, Bicinchoninic Acid Protein Assay, Reverse Transcription, Quantitative Proteomics, Software



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    Image Search Results


    Obesity impairs oocyte maturation and mtDNA activity. A) Number of pups per litter born from female mice fed control (CON) and obesogenic diet (OB) (n = 12). B) H&E staining of ovaries and follicles. Scale bar 200 µm, 50 µm (n = 8). The number of primary, secondary and antral follicles per section of ovary in CON and OB females (n = 8). C, D) The mature oocytes were collected in the fallopian tubes, and the number of MII oocytes and the proportion of abnormal MII oocytes were counted. Stars indicate the abnormal oocytes, and scale bar 50 µm (n = 15). E) Immunoblotting of oocyte maturation indicators in MII oocytes, including BMP15, GDF‐9, active caspase‐7, and active caspase‐3. β‐Tubulin was used as a loading control (n = 5). F) Immunoblotting of mitochondrial fission and biomass indicators in MII oocytes, including Drp1, Drp1‐S616, VDAC and Tom20. β‐Tubulin was used as a loading control (n = 5). G) mtDNA content in mature oocytes (n = 6). H) mRNA expression of mtDNA genes involved in respiration chain complex (n = 6). I) O 2 consumption was measured in mature oocytes (n = 5; 70 oocytes were pooled per replicate). Data are presented as mean ± s.e.m. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001; unpaired two‐tail Student's t test was used in analyses.

    Journal: Advanced Science

    Article Title: AMPK Suppression Due to Obesity Drives Oocyte mtDNA Heteroplasmy via ATF5‐POLG Axis

    doi: 10.1002/advs.202307480

    Figure Lengend Snippet: Obesity impairs oocyte maturation and mtDNA activity. A) Number of pups per litter born from female mice fed control (CON) and obesogenic diet (OB) (n = 12). B) H&E staining of ovaries and follicles. Scale bar 200 µm, 50 µm (n = 8). The number of primary, secondary and antral follicles per section of ovary in CON and OB females (n = 8). C, D) The mature oocytes were collected in the fallopian tubes, and the number of MII oocytes and the proportion of abnormal MII oocytes were counted. Stars indicate the abnormal oocytes, and scale bar 50 µm (n = 15). E) Immunoblotting of oocyte maturation indicators in MII oocytes, including BMP15, GDF‐9, active caspase‐7, and active caspase‐3. β‐Tubulin was used as a loading control (n = 5). F) Immunoblotting of mitochondrial fission and biomass indicators in MII oocytes, including Drp1, Drp1‐S616, VDAC and Tom20. β‐Tubulin was used as a loading control (n = 5). G) mtDNA content in mature oocytes (n = 6). H) mRNA expression of mtDNA genes involved in respiration chain complex (n = 6). I) O 2 consumption was measured in mature oocytes (n = 5; 70 oocytes were pooled per replicate). Data are presented as mean ± s.e.m. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001; unpaired two‐tail Student's t test was used in analyses.

    Article Snippet: [ , ] Membrane were probed using primary antibodies, including BMP‐15 (#18 982; Proteintech), GDF‐9 (af739; Novus), Caspase‐7 (sc‐56063; Snta‐Cruz), Caspase‐3 (#9662; Cell Signaling), β‐tubulin (#179 513; Abcam), DRP1 (#8570; Cell Signaling), p‐DRP1 (#3455; Cell Signaling), VDAC (#4866; Cell Signaling), TOM20 (sc‐17764; Santa Cruz), ATF5 (ab184923; Abcam), LonP1 (#15 440; Proteintech), POLG (ab128899; Abcam), HSP70 (#4872; Cell Signaling), AMPKa (D63G4; Cell Signaling), p‐AMPKa (#2535; Cell Signaling), GAPDH (#97 166; Cell Signaling).

    Techniques: Activity Assay, Staining, Western Blot, Expressing

    AMPK activation improves oocyte maturation and limits mtDNA heteroplasmy in obese females. A) Obese females were fed metformin in drinking water for 4‐weeks (OB+Metf). Immunoblotting of AMPKa, AMPKa phosphorylation at Thr‐172, BMP15, GDF‐9, ATF5, POLG and LonP1 proteins in mature oocytes of control (CON), obese (OB) and OB+Metf females. The β‐tubulin was used as a loading control (n = 5). B) H&E staining in ovary. The primary, secondary and mature oocytes were quantified in each ovary section (n = 5). C) Immunostaining of MitoSpy (green color) and TMRE (red color) in mature oocytes. Fluorescent intensity was qualified by ImageJ and normalized by MitoSpy/TMRE. Five mature oocytes were used in the analyses. Scar bar MitoSpy, 200 µm; bright field, 150 µm; TMRE, 80 µm. D) Number of pups per litter born from female mice. E) Co‐immunoprecipitation of ATF5 in measuring POLG in mature oocytes. ATF5 and POLG were immunoprecipitated followed with SDS‐PAGE separation and measured in immunoblotting. IgG was used as a negative control in immunoprecipitation. F) Percentage of mtDNA heteroplasmy and total mutation sites in mature oocytes from mtDNA‐sequencing (n = 5). Data are presented as mean ± s.e.m. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001; one‐way ANOVA was used in analysis.

    Journal: Advanced Science

    Article Title: AMPK Suppression Due to Obesity Drives Oocyte mtDNA Heteroplasmy via ATF5‐POLG Axis

    doi: 10.1002/advs.202307480

    Figure Lengend Snippet: AMPK activation improves oocyte maturation and limits mtDNA heteroplasmy in obese females. A) Obese females were fed metformin in drinking water for 4‐weeks (OB+Metf). Immunoblotting of AMPKa, AMPKa phosphorylation at Thr‐172, BMP15, GDF‐9, ATF5, POLG and LonP1 proteins in mature oocytes of control (CON), obese (OB) and OB+Metf females. The β‐tubulin was used as a loading control (n = 5). B) H&E staining in ovary. The primary, secondary and mature oocytes were quantified in each ovary section (n = 5). C) Immunostaining of MitoSpy (green color) and TMRE (red color) in mature oocytes. Fluorescent intensity was qualified by ImageJ and normalized by MitoSpy/TMRE. Five mature oocytes were used in the analyses. Scar bar MitoSpy, 200 µm; bright field, 150 µm; TMRE, 80 µm. D) Number of pups per litter born from female mice. E) Co‐immunoprecipitation of ATF5 in measuring POLG in mature oocytes. ATF5 and POLG were immunoprecipitated followed with SDS‐PAGE separation and measured in immunoblotting. IgG was used as a negative control in immunoprecipitation. F) Percentage of mtDNA heteroplasmy and total mutation sites in mature oocytes from mtDNA‐sequencing (n = 5). Data are presented as mean ± s.e.m. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001; one‐way ANOVA was used in analysis.

    Article Snippet: [ , ] Membrane were probed using primary antibodies, including BMP‐15 (#18 982; Proteintech), GDF‐9 (af739; Novus), Caspase‐7 (sc‐56063; Snta‐Cruz), Caspase‐3 (#9662; Cell Signaling), β‐tubulin (#179 513; Abcam), DRP1 (#8570; Cell Signaling), p‐DRP1 (#3455; Cell Signaling), VDAC (#4866; Cell Signaling), TOM20 (sc‐17764; Santa Cruz), ATF5 (ab184923; Abcam), LonP1 (#15 440; Proteintech), POLG (ab128899; Abcam), HSP70 (#4872; Cell Signaling), AMPKa (D63G4; Cell Signaling), p‐AMPKa (#2535; Cell Signaling), GAPDH (#97 166; Cell Signaling).

    Techniques: Activation Assay, Western Blot, Staining, Immunostaining, Immunoprecipitation, SDS Page, Negative Control, Mutagenesis, Sequencing

    KEY RESOURCES TABLE

    Journal: Cell reports

    Article Title: Directed differentiation of human iPSCs into mesenchymal lineages by optogenetic control of TGF-β signaling

    doi: 10.1016/j.celrep.2023.112509

    Figure Lengend Snippet: KEY RESOURCES TABLE

    Article Snippet: Recombinant Human GDF-7 , Peprotech , Cat# 120-37.

    Techniques: Affinity Purification, Virus, Recombinant, Protease Inhibitor, SYBR Green Assay, Solvent, Plasmid Preparation, Control, Functional Assay, Bicinchoninic Acid Protein Assay, Reverse Transcription, Quantitative Proteomics, Software