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glp-1r agonist ex4  (Tocris)


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    Tocris glp-1r agonist ex4
    Glp 1r Agonist Ex4, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/glp-1r agonist ex4/product/Tocris
    Average 90 stars, based on 1 article reviews
    glp-1r agonist ex4 - by Bioz Stars, 2026-03
    90/100 stars

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    ( A – D ) Control ( n = 34) or Gnas βcell–/– ( n = 23) mice were treated with PBS, D-Ala2-GIP ( A and B ), or Ex4 ( C and D ) at t = –10 minutes. Mice were then challenged with i.p. glucose (1.5 g/kg) and iAUC presented from t = 0. Insulin secretion in D-Ala2-GIP–challenged ( B , n = 23,14) and Ex4-challenged ( D , n = 21,13) mice are shown at baseline ( t = 0) and 10 minutes after glucose challenge ( t = 10). Data are shown as mean ± SEM, * P < 0.05 as indicated. Data were analyzed by 2-way ANOVA of glycemic curves and insulin levels or 2-tailed Student’s t test of the iAUCs.

    Journal: The Journal of Clinical Investigation

    Article Title: β Cell Gαs signaling is critical for physiological and pharmacological enhancement of insulin secretion

    doi: 10.1172/JCI183741

    Figure Lengend Snippet: ( A – D ) Control ( n = 34) or Gnas βcell–/– ( n = 23) mice were treated with PBS, D-Ala2-GIP ( A and B ), or Ex4 ( C and D ) at t = –10 minutes. Mice were then challenged with i.p. glucose (1.5 g/kg) and iAUC presented from t = 0. Insulin secretion in D-Ala2-GIP–challenged ( B , n = 23,14) and Ex4-challenged ( D , n = 21,13) mice are shown at baseline ( t = 0) and 10 minutes after glucose challenge ( t = 10). Data are shown as mean ± SEM, * P < 0.05 as indicated. Data were analyzed by 2-way ANOVA of glycemic curves and insulin levels or 2-tailed Student’s t test of the iAUCs.

    Article Snippet: Ex4 was purchased from MedChemExpress.

    Techniques: Control