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Nanotherapeutics doxil
Doxil, supplied by Nanotherapeutics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/doxil/doxil/10__1016_slash_j__nantod__2026__103040-32-14-6
Average 86 stars, based on 1 article reviews
doxil - by Bioz Stars, 2026-10
86/100 stars

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Related Articles

Liposomes:

Article Title: Nitric Oxide-Responsive Degradable Drug-Loaded Liposomal Nanomotors for the Treatment of Peritoneal Metastases Cancer.
Article Snippet: As a drug delivery vehicle, liposomes still have problems such as lack of targeting, difficulty in achieving effective tumor tissue penetration, and cellular internalization.. Based on this, the drug-loaded liposome nanomotors with liposomes that can respond to NO degradation as carriers and loaded with anticancer drug DOX were designed for the treatment of peritoneal metastases cancer (arginine-functionalized-DSPE@NO-responsive-lipids-DOX, L-Arg@Lip-DOX).. The drug-loaded liposomal nanomotors have the ability to move toward tumors at high concentrations of ROS/iNOS, thereby achieving deep penetration and effective cellular internalization of tumor tissues.

Membrane:

Article Title: Nitric Oxide-Responsive Degradable Drug-Loaded Liposomal Nanomotors for the Treatment of Peritoneal Metastases Cancer.
Article Snippet: As a drug delivery vehicle, liposomes still have problems such as lack of targeting, difficulty in achieving effective tumor tissue penetration, and cellular internalization.. Based on this, the drug-loaded liposome nanomotors with liposomes that can respond to NO degradation as carriers and loaded with anticancer drug DOX were designed for the treatment of peritoneal metastases cancer (arginine-functionalized-DSPE@NO-responsive-lipids-DOX, L-Arg@Lip-DOX).. The drug-loaded liposomal nanomotors have the ability to move toward tumors at high concentrations of ROS/iNOS, thereby achieving deep penetration and effective cellular internalization of tumor tissues.

Article Title: Development of Dual Diagnostic-Therapeutic Nanoformulation Effective Against Pancreatic Cancer in Animal Model
Article Snippet: .. Extracellular matrix proteins produced by CAFs in the tumor stroma impede the effective delivery of chemotherapeutic agents,11,12 resulting in poor responses in patients with pancreatic cancer.13 Due to recent advances in nanotechnology, the application of nanoparticles in cancer therapy has become a leading area in cancer research.12,14,15 Nanotherapeutics can achieve better therapeutic effects on tumors than free drugs based on the enhanced permeability and retention (EPR) effect of tumors.16 However, the benefits of anti-tumor nanotherapeutics such as Doxil and Abraxane, two nanotherapeutics approved by the Food and Drug Administration (FDA) for use in solid tumors, are still far from satisfactory.17 As an extension, active targeting drug delivery systems, which are modified with targeting moieties with special affinity to the corresponding antigens overexpressed in tumor tissues, have been explored to achieve additional anti-tumor efficacy compared to those based on the EPR effect alone.18,19 Therefore, suitable antigens overexpressed by both cells and the corresponding targeting moieties can be selected for active drug delivery systems that simultaneously target both myeloma cells and CAFs to achieve a strong therapeutic effect for PDAC treatment.20 In tumors, cancer cell surface antigens have homologous or heterologous adhesion properties.21 These properties are attributed to Graphical Abstract https://doi.org/10.2147/IJN.S464788 DovePress International Journal of Nanomedicine 2024:19 9122 Powered by TCPDF (www.tcpdf.org) plasma membrane proteins on the surface of cancer cells, including N-calmodulin, galactoglucan-3, and epithelial cell adhesion molecules,22 and the surface-encapsulated cancer cell membrane (CCM) of NPs competes for homotypic cancer cell surface antigens, acquiring immune escape and homology-targeting capabilities that can be used for highly specific cancer targeting and effective cancer Treatment. ..

Encapsulation:

Article Title: Self-illuminating activatable chemotherapy enabled by pH-MPO-ROS cascade-amplified nanoparticles for cancer and metastatic lymph nodes
Article Snippet: Lymph nodes (LNs) are the primary site of metastasis for various cancers spreading through the lymphatic system.. The role of lymph node dissection, as outlined by clinical guidelines, has increasingly been called into question.. Here, we developed a self-illuminating and pH-MPO-ROS cascade-activatable paclitaxel nanoparticle (PCAPN), which integrates ultra-pH-sensitive, self-illuminated imaging, in situ cascade gated activation of therapeutic agents to specifically eliminate the residual tumors and metastatic LNs after surgery.

Produced:

Article Title: Development of Dual Diagnostic-Therapeutic Nanoformulation Effective Against Pancreatic Cancer in Animal Model
Article Snippet: .. Extracellular matrix proteins produced by CAFs in the tumor stroma impede the effective delivery of chemotherapeutic agents,11,12 resulting in poor responses in patients with pancreatic cancer.13 Due to recent advances in nanotechnology, the application of nanoparticles in cancer therapy has become a leading area in cancer research.12,14,15 Nanotherapeutics can achieve better therapeutic effects on tumors than free drugs based on the enhanced permeability and retention (EPR) effect of tumors.16 However, the benefits of anti-tumor nanotherapeutics such as Doxil and Abraxane, two nanotherapeutics approved by the Food and Drug Administration (FDA) for use in solid tumors, are still far from satisfactory.17 As an extension, active targeting drug delivery systems, which are modified with targeting moieties with special affinity to the corresponding antigens overexpressed in tumor tissues, have been explored to achieve additional anti-tumor efficacy compared to those based on the EPR effect alone.18,19 Therefore, suitable antigens overexpressed by both cells and the corresponding targeting moieties can be selected for active drug delivery systems that simultaneously target both myeloma cells and CAFs to achieve a strong therapeutic effect for PDAC treatment.20 In tumors, cancer cell surface antigens have homologous or heterologous adhesion properties.21 These properties are attributed to Graphical Abstract https://doi.org/10.2147/IJN.S464788 DovePress International Journal of Nanomedicine 2024:19 9122 Powered by TCPDF (www.tcpdf.org) plasma membrane proteins on the surface of cancer cells, including N-calmodulin, galactoglucan-3, and epithelial cell adhesion molecules,22 and the surface-encapsulated cancer cell membrane (CCM) of NPs competes for homotypic cancer cell surface antigens, acquiring immune escape and homology-targeting capabilities that can be used for highly specific cancer targeting and effective cancer Treatment. ..

Permeability:

Article Title: Development of Dual Diagnostic-Therapeutic Nanoformulation Effective Against Pancreatic Cancer in Animal Model
Article Snippet: .. Extracellular matrix proteins produced by CAFs in the tumor stroma impede the effective delivery of chemotherapeutic agents,11,12 resulting in poor responses in patients with pancreatic cancer.13 Due to recent advances in nanotechnology, the application of nanoparticles in cancer therapy has become a leading area in cancer research.12,14,15 Nanotherapeutics can achieve better therapeutic effects on tumors than free drugs based on the enhanced permeability and retention (EPR) effect of tumors.16 However, the benefits of anti-tumor nanotherapeutics such as Doxil and Abraxane, two nanotherapeutics approved by the Food and Drug Administration (FDA) for use in solid tumors, are still far from satisfactory.17 As an extension, active targeting drug delivery systems, which are modified with targeting moieties with special affinity to the corresponding antigens overexpressed in tumor tissues, have been explored to achieve additional anti-tumor efficacy compared to those based on the EPR effect alone.18,19 Therefore, suitable antigens overexpressed by both cells and the corresponding targeting moieties can be selected for active drug delivery systems that simultaneously target both myeloma cells and CAFs to achieve a strong therapeutic effect for PDAC treatment.20 In tumors, cancer cell surface antigens have homologous or heterologous adhesion properties.21 These properties are attributed to Graphical Abstract https://doi.org/10.2147/IJN.S464788 DovePress International Journal of Nanomedicine 2024:19 9122 Powered by TCPDF (www.tcpdf.org) plasma membrane proteins on the surface of cancer cells, including N-calmodulin, galactoglucan-3, and epithelial cell adhesion molecules,22 and the surface-encapsulated cancer cell membrane (CCM) of NPs competes for homotypic cancer cell surface antigens, acquiring immune escape and homology-targeting capabilities that can be used for highly specific cancer targeting and effective cancer Treatment. ..

Food & Beverages:

Article Title: Development of Dual Diagnostic-Therapeutic Nanoformulation Effective Against Pancreatic Cancer in Animal Model
Article Snippet: .. Extracellular matrix proteins produced by CAFs in the tumor stroma impede the effective delivery of chemotherapeutic agents,11,12 resulting in poor responses in patients with pancreatic cancer.13 Due to recent advances in nanotechnology, the application of nanoparticles in cancer therapy has become a leading area in cancer research.12,14,15 Nanotherapeutics can achieve better therapeutic effects on tumors than free drugs based on the enhanced permeability and retention (EPR) effect of tumors.16 However, the benefits of anti-tumor nanotherapeutics such as Doxil and Abraxane, two nanotherapeutics approved by the Food and Drug Administration (FDA) for use in solid tumors, are still far from satisfactory.17 As an extension, active targeting drug delivery systems, which are modified with targeting moieties with special affinity to the corresponding antigens overexpressed in tumor tissues, have been explored to achieve additional anti-tumor efficacy compared to those based on the EPR effect alone.18,19 Therefore, suitable antigens overexpressed by both cells and the corresponding targeting moieties can be selected for active drug delivery systems that simultaneously target both myeloma cells and CAFs to achieve a strong therapeutic effect for PDAC treatment.20 In tumors, cancer cell surface antigens have homologous or heterologous adhesion properties.21 These properties are attributed to Graphical Abstract https://doi.org/10.2147/IJN.S464788 DovePress International Journal of Nanomedicine 2024:19 9122 Powered by TCPDF (www.tcpdf.org) plasma membrane proteins on the surface of cancer cells, including N-calmodulin, galactoglucan-3, and epithelial cell adhesion molecules,22 and the surface-encapsulated cancer cell membrane (CCM) of NPs competes for homotypic cancer cell surface antigens, acquiring immune escape and homology-targeting capabilities that can be used for highly specific cancer targeting and effective cancer Treatment. ..

Modification:

Article Title: Development of Dual Diagnostic-Therapeutic Nanoformulation Effective Against Pancreatic Cancer in Animal Model
Article Snippet: .. Extracellular matrix proteins produced by CAFs in the tumor stroma impede the effective delivery of chemotherapeutic agents,11,12 resulting in poor responses in patients with pancreatic cancer.13 Due to recent advances in nanotechnology, the application of nanoparticles in cancer therapy has become a leading area in cancer research.12,14,15 Nanotherapeutics can achieve better therapeutic effects on tumors than free drugs based on the enhanced permeability and retention (EPR) effect of tumors.16 However, the benefits of anti-tumor nanotherapeutics such as Doxil and Abraxane, two nanotherapeutics approved by the Food and Drug Administration (FDA) for use in solid tumors, are still far from satisfactory.17 As an extension, active targeting drug delivery systems, which are modified with targeting moieties with special affinity to the corresponding antigens overexpressed in tumor tissues, have been explored to achieve additional anti-tumor efficacy compared to those based on the EPR effect alone.18,19 Therefore, suitable antigens overexpressed by both cells and the corresponding targeting moieties can be selected for active drug delivery systems that simultaneously target both myeloma cells and CAFs to achieve a strong therapeutic effect for PDAC treatment.20 In tumors, cancer cell surface antigens have homologous or heterologous adhesion properties.21 These properties are attributed to Graphical Abstract https://doi.org/10.2147/IJN.S464788 DovePress International Journal of Nanomedicine 2024:19 9122 Powered by TCPDF (www.tcpdf.org) plasma membrane proteins on the surface of cancer cells, including N-calmodulin, galactoglucan-3, and epithelial cell adhesion molecules,22 and the surface-encapsulated cancer cell membrane (CCM) of NPs competes for homotypic cancer cell surface antigens, acquiring immune escape and homology-targeting capabilities that can be used for highly specific cancer targeting and effective cancer Treatment. ..

Clinical Proteomics:

Article Title: Development of Dual Diagnostic-Therapeutic Nanoformulation Effective Against Pancreatic Cancer in Animal Model
Article Snippet: .. Extracellular matrix proteins produced by CAFs in the tumor stroma impede the effective delivery of chemotherapeutic agents,11,12 resulting in poor responses in patients with pancreatic cancer.13 Due to recent advances in nanotechnology, the application of nanoparticles in cancer therapy has become a leading area in cancer research.12,14,15 Nanotherapeutics can achieve better therapeutic effects on tumors than free drugs based on the enhanced permeability and retention (EPR) effect of tumors.16 However, the benefits of anti-tumor nanotherapeutics such as Doxil and Abraxane, two nanotherapeutics approved by the Food and Drug Administration (FDA) for use in solid tumors, are still far from satisfactory.17 As an extension, active targeting drug delivery systems, which are modified with targeting moieties with special affinity to the corresponding antigens overexpressed in tumor tissues, have been explored to achieve additional anti-tumor efficacy compared to those based on the EPR effect alone.18,19 Therefore, suitable antigens overexpressed by both cells and the corresponding targeting moieties can be selected for active drug delivery systems that simultaneously target both myeloma cells and CAFs to achieve a strong therapeutic effect for PDAC treatment.20 In tumors, cancer cell surface antigens have homologous or heterologous adhesion properties.21 These properties are attributed to Graphical Abstract https://doi.org/10.2147/IJN.S464788 DovePress International Journal of Nanomedicine 2024:19 9122 Powered by TCPDF (www.tcpdf.org) plasma membrane proteins on the surface of cancer cells, including N-calmodulin, galactoglucan-3, and epithelial cell adhesion molecules,22 and the surface-encapsulated cancer cell membrane (CCM) of NPs competes for homotypic cancer cell surface antigens, acquiring immune escape and homology-targeting capabilities that can be used for highly specific cancer targeting and effective cancer Treatment. ..

other:

Article Title: Long-acting lipid-based nanomedicines: rethinking from structure-based rational design to in vivo fate evaluation.
Article Snippet: Long-acting lipid-based nanomedicines (LaLBNs) aim to sustain therapeutic effect through prolonged exposure and controlled drug release.. However, extended circulation does not always translate into improved clinical outcomes.. For instance, polyethylene glycol (PEG)-modified liposomes show enhanced pharmacokinetic (PK) parameters such as half-life and area under the curve, yet their benefits, as observed with Doxil®, often fail to meaningfully surpass free doxorubicin.



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