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cstf2  (Proteintech)


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    Structured Review

    Proteintech cstf2
    Cstf2, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cstf2/CstF-64+Antibody/pm41310899-64-15-18
    Average 93 stars, based on 9 article reviews
    cstf2 - by Bioz Stars, 2026-09
    93/100 stars

    Images

    Related Articles

    Immunohistochemistry:

    Article Title: CSTF2 Promotes Hepatocarcinogenesis and Hepatocellular Carcinoma Progression via Aerobic Glycolysis.
    Article Snippet: Tissue array chips were purchased from Servicebio (ZL-LivHCC961, Shanghai, China), and included HCC tissues (n = 48) and adjacent normal liver tissues (n = 48). .. Immunohistochemistry was executed on a tissue array chip using CSTF2 (1:200, Proteintech, China). .. Total RNA was extracted using TRIzol reagent (Life Technologies, #15596018) and reverse transcribed into cDNA using the PrimeScript RT reagent kit (Takara, Shiga, Japan).

    Incubation:

    Article Title: CSTF2 Supports Hypoxia Tolerance in Hepatocellular Carcinoma by Enabling m6A Modification Evasion of PGK1 to Enhance Glycolysis
    Article Snippet: Cleavage stimulation factor subunit 2 (CSTF2) is a fundamental factor in the regulation of 3-end cleavage and alternative polyadenylation of pre-mRNAs.. Previous work has identified a tumor-promoting role of CSTF2, suggesting that it may represent a potential therapeutic target.. In this study, we aimed to elucidate the mechanistic function of CSTF2 in hepatocellular carcinoma (HCC).

    Western Blot:

    Article Title: p53 inhibits mRNA 3' processing through its interaction with the CstF/BARD1 complex.
    Article Snippet: .. Sixty micrograms of each NE was analyzed by immunoblotting with antibodies against BARD1 (H-300, Santa Cruz Biotechnology, Santa Cruz, CA, USA), p53 (SC-126, Santa Cruz), CstF2 (generously provided by Dr Manley, Columbia University, New York, NY, USA), CstF1 (10064-2-AP, Protein Tech Group, Chicago, IL, USA) and Topoisomerase II (Topo II, SC-25330, Santa Cruz). siRNA knockdown of p53 expression in HeLa and MCF7 cells The siRNA specific for human p53 was synthesized by Qiagen (Valencia, CA, USA) and the control RNA duplex used as non-silencing siRNA was obtained from Dharmacon RNA Technologies (Lafayette, CO, USA). ..

    Knockdown:

    Article Title: p53 inhibits mRNA 3' processing through its interaction with the CstF/BARD1 complex.
    Article Snippet: .. Sixty micrograms of each NE was analyzed by immunoblotting with antibodies against BARD1 (H-300, Santa Cruz Biotechnology, Santa Cruz, CA, USA), p53 (SC-126, Santa Cruz), CstF2 (generously provided by Dr Manley, Columbia University, New York, NY, USA), CstF1 (10064-2-AP, Protein Tech Group, Chicago, IL, USA) and Topoisomerase II (Topo II, SC-25330, Santa Cruz). siRNA knockdown of p53 expression in HeLa and MCF7 cells The siRNA specific for human p53 was synthesized by Qiagen (Valencia, CA, USA) and the control RNA duplex used as non-silencing siRNA was obtained from Dharmacon RNA Technologies (Lafayette, CO, USA). ..

    Expressing:

    Article Title: p53 inhibits mRNA 3' processing through its interaction with the CstF/BARD1 complex.
    Article Snippet: .. Sixty micrograms of each NE was analyzed by immunoblotting with antibodies against BARD1 (H-300, Santa Cruz Biotechnology, Santa Cruz, CA, USA), p53 (SC-126, Santa Cruz), CstF2 (generously provided by Dr Manley, Columbia University, New York, NY, USA), CstF1 (10064-2-AP, Protein Tech Group, Chicago, IL, USA) and Topoisomerase II (Topo II, SC-25330, Santa Cruz). siRNA knockdown of p53 expression in HeLa and MCF7 cells The siRNA specific for human p53 was synthesized by Qiagen (Valencia, CA, USA) and the control RNA duplex used as non-silencing siRNA was obtained from Dharmacon RNA Technologies (Lafayette, CO, USA). ..

    Synthesized:

    Article Title: p53 inhibits mRNA 3' processing through its interaction with the CstF/BARD1 complex.
    Article Snippet: .. Sixty micrograms of each NE was analyzed by immunoblotting with antibodies against BARD1 (H-300, Santa Cruz Biotechnology, Santa Cruz, CA, USA), p53 (SC-126, Santa Cruz), CstF2 (generously provided by Dr Manley, Columbia University, New York, NY, USA), CstF1 (10064-2-AP, Protein Tech Group, Chicago, IL, USA) and Topoisomerase II (Topo II, SC-25330, Santa Cruz). siRNA knockdown of p53 expression in HeLa and MCF7 cells The siRNA specific for human p53 was synthesized by Qiagen (Valencia, CA, USA) and the control RNA duplex used as non-silencing siRNA was obtained from Dharmacon RNA Technologies (Lafayette, CO, USA). ..

    Control:

    Article Title: p53 inhibits mRNA 3' processing through its interaction with the CstF/BARD1 complex.
    Article Snippet: .. Sixty micrograms of each NE was analyzed by immunoblotting with antibodies against BARD1 (H-300, Santa Cruz Biotechnology, Santa Cruz, CA, USA), p53 (SC-126, Santa Cruz), CstF2 (generously provided by Dr Manley, Columbia University, New York, NY, USA), CstF1 (10064-2-AP, Protein Tech Group, Chicago, IL, USA) and Topoisomerase II (Topo II, SC-25330, Santa Cruz). siRNA knockdown of p53 expression in HeLa and MCF7 cells The siRNA specific for human p53 was synthesized by Qiagen (Valencia, CA, USA) and the control RNA duplex used as non-silencing siRNA was obtained from Dharmacon RNA Technologies (Lafayette, CO, USA). ..

    other:

    Article Title: A Novel Gene Pair CSTF2/DPE2A Impacts Prognosis and Cell Cycle of Hepatocellular Carcinoma
    Article Snippet: CSTF2 , 26825-1-AP , 1:1000 , Proteintech Group, United States.



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    Image Search Results


    CSTF2 is abundantly present in gastric cancer. A Pancancer analysis showed that CSTF2 was highly expressed across diverse types of cancers, gastric cancer included. B Immunohistochemistry analysis of CSTF2 in gastric cancerous tissues and regular tissues. C CSTF2 RNA expression degrees in gastric cancer tissues and healthy specimens were compared. D OS/DFS curves analyzed by Kaplan–Meier method; differences assessed by log-rank test

    Journal: European Journal of Medical Research

    Article Title: The role of CSTF2 in gastric cancer: implications for therapy

    doi: 10.1186/s40001-025-03570-8

    Figure Lengend Snippet: CSTF2 is abundantly present in gastric cancer. A Pancancer analysis showed that CSTF2 was highly expressed across diverse types of cancers, gastric cancer included. B Immunohistochemistry analysis of CSTF2 in gastric cancerous tissues and regular tissues. C CSTF2 RNA expression degrees in gastric cancer tissues and healthy specimens were compared. D OS/DFS curves analyzed by Kaplan–Meier method; differences assessed by log-rank test

    Article Snippet: Antibodies against CSTF2 (1:1000; sc-374373; Santa Cruz Biotechnology, USA) and TGM2 (1:1000; sc-21733; Santa Cruz Biotechnology, USA) were used.

    Techniques: Immunohistochemistry, RNA Expression

    CSTF2 drives the expansion of gastric cancer tissues. A WB was used to assess CSTF2 protein degrees in gastric cancer specimens. B Proliferation patterns of BGC-823 and MKN-28 cells. C Assay for colony formation of BGC-823 and MKN-28 cells. D Tumour images and data obtained after stable transfection of gastric cancer specimens with shNC or shCSTF2 and xenografting. All the experiments were replicated at least thrice. A two-tailed independent t test was used. * P < 0.05 and ** P < 0.01. The number of technical replicates for cell experiments is ≥ 3

    Journal: European Journal of Medical Research

    Article Title: The role of CSTF2 in gastric cancer: implications for therapy

    doi: 10.1186/s40001-025-03570-8

    Figure Lengend Snippet: CSTF2 drives the expansion of gastric cancer tissues. A WB was used to assess CSTF2 protein degrees in gastric cancer specimens. B Proliferation patterns of BGC-823 and MKN-28 cells. C Assay for colony formation of BGC-823 and MKN-28 cells. D Tumour images and data obtained after stable transfection of gastric cancer specimens with shNC or shCSTF2 and xenografting. All the experiments were replicated at least thrice. A two-tailed independent t test was used. * P < 0.05 and ** P < 0.01. The number of technical replicates for cell experiments is ≥ 3

    Article Snippet: Antibodies against CSTF2 (1:1000; sc-374373; Santa Cruz Biotechnology, USA) and TGM2 (1:1000; sc-21733; Santa Cruz Biotechnology, USA) were used.

    Techniques: Stable Transfection, Two Tailed Test

    CSTF2 promotes migration and invasion of gastric cancer cells. A Cell migration assay of BGC-823 and MKN-28 cells. B Cell invasion assay of BGC-823 and MKN-28 cells. All experiments were independently repeated at least three times. Statistical significance was determined by a two-tailed independent t test (** P < 0.01)

    Journal: European Journal of Medical Research

    Article Title: The role of CSTF2 in gastric cancer: implications for therapy

    doi: 10.1186/s40001-025-03570-8

    Figure Lengend Snippet: CSTF2 promotes migration and invasion of gastric cancer cells. A Cell migration assay of BGC-823 and MKN-28 cells. B Cell invasion assay of BGC-823 and MKN-28 cells. All experiments were independently repeated at least three times. Statistical significance was determined by a two-tailed independent t test (** P < 0.01)

    Article Snippet: Antibodies against CSTF2 (1:1000; sc-374373; Santa Cruz Biotechnology, USA) and TGM2 (1:1000; sc-21733; Santa Cruz Biotechnology, USA) were used.

    Techniques: Migration, Cell Migration Assay, Invasion Assay, Two Tailed Test

    CSTF2 regulates the expression of TGM2. A Volcano plot displays gene expression changes following CSTF2 inhibition. B GO analysis of differentially expressed genes after CSTF2 knockdown. C KEGG analysis of genes with changed expression intensity after CSTF2 knockdown

    Journal: European Journal of Medical Research

    Article Title: The role of CSTF2 in gastric cancer: implications for therapy

    doi: 10.1186/s40001-025-03570-8

    Figure Lengend Snippet: CSTF2 regulates the expression of TGM2. A Volcano plot displays gene expression changes following CSTF2 inhibition. B GO analysis of differentially expressed genes after CSTF2 knockdown. C KEGG analysis of genes with changed expression intensity after CSTF2 knockdown

    Article Snippet: Antibodies against CSTF2 (1:1000; sc-374373; Santa Cruz Biotechnology, USA) and TGM2 (1:1000; sc-21733; Santa Cruz Biotechnology, USA) were used.

    Techniques: Expressing, Gene Expression, Inhibition, Knockdown

    Screening of the downstream gene TGM2. A Venn diagram showing the number of downregulated genes after knockdown of CSTF2 in BGC-823 and MKN-28 cells, with 15 genes overlapping. B mRNA expression levels of CSTF2 and TGM2 after CSTF2 knockdown in different groups, as determined by qRT-PCR. C Spearman correlation analysis of the expression levels between CSTF2 and TGM2. D Protein expression levels of CSTF2 and TGM2 after CSTF2 knockdown, as assessed by western blotting. E BGC-823 and MKN-28 cells were treated with actinomycin D (10 ug/ml) and harvested at 0, 2, 4, 6, and 8 h for RNA extraction. TGM2 mRNA levels were measured by qPCR at the different timepoints, using GAPDH as input control. F Representative immunohistochemistry (IHC) images of TGM2 expression in gastric cancer tissues and adjacent normal tissues (magnification: 200x). All experiments were independently repeated at least three times. Statistical significance was determined by a two-tailed independent t test (* P < 0.05, ** P < 0.01, *** P < 0.001)

    Journal: European Journal of Medical Research

    Article Title: The role of CSTF2 in gastric cancer: implications for therapy

    doi: 10.1186/s40001-025-03570-8

    Figure Lengend Snippet: Screening of the downstream gene TGM2. A Venn diagram showing the number of downregulated genes after knockdown of CSTF2 in BGC-823 and MKN-28 cells, with 15 genes overlapping. B mRNA expression levels of CSTF2 and TGM2 after CSTF2 knockdown in different groups, as determined by qRT-PCR. C Spearman correlation analysis of the expression levels between CSTF2 and TGM2. D Protein expression levels of CSTF2 and TGM2 after CSTF2 knockdown, as assessed by western blotting. E BGC-823 and MKN-28 cells were treated with actinomycin D (10 ug/ml) and harvested at 0, 2, 4, 6, and 8 h for RNA extraction. TGM2 mRNA levels were measured by qPCR at the different timepoints, using GAPDH as input control. F Representative immunohistochemistry (IHC) images of TGM2 expression in gastric cancer tissues and adjacent normal tissues (magnification: 200x). All experiments were independently repeated at least three times. Statistical significance was determined by a two-tailed independent t test (* P < 0.05, ** P < 0.01, *** P < 0.001)

    Article Snippet: Antibodies against CSTF2 (1:1000; sc-374373; Santa Cruz Biotechnology, USA) and TGM2 (1:1000; sc-21733; Santa Cruz Biotechnology, USA) were used.

    Techniques: Knockdown, Expressing, Quantitative RT-PCR, Western Blot, RNA Extraction, Control, Immunohistochemistry, Two Tailed Test

    Rescue experiments. A Protein expression amounts of CSTF2 and TGM2. B Proliferation of BGC-823 and MKN-28. C Colony establishment assay of BGC-823 and MKN-28. Each experiment was conducted a minimum of three times to ensure accuracy. A two-tailed independent t test was used. The number of technical replicates for cell experiments is ≥ 3. ** P < 0.01

    Journal: European Journal of Medical Research

    Article Title: The role of CSTF2 in gastric cancer: implications for therapy

    doi: 10.1186/s40001-025-03570-8

    Figure Lengend Snippet: Rescue experiments. A Protein expression amounts of CSTF2 and TGM2. B Proliferation of BGC-823 and MKN-28. C Colony establishment assay of BGC-823 and MKN-28. Each experiment was conducted a minimum of three times to ensure accuracy. A two-tailed independent t test was used. The number of technical replicates for cell experiments is ≥ 3. ** P < 0.01

    Article Snippet: Antibodies against CSTF2 (1:1000; sc-374373; Santa Cruz Biotechnology, USA) and TGM2 (1:1000; sc-21733; Santa Cruz Biotechnology, USA) were used.

    Techniques: Expressing, Two Tailed Test