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matn1  (Bioss)


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    Bioss matn1
    Characterization of vertebral chondrocytes during early IVD formation. A) UMAP visualization (upper) of the four vertebral chondrocyte subclusters defined during human early IVD formation at the Noto, Trans, and NPL stages (lower). B) UMAP plots and violin plots showing the expressions of MATN4 , COL2A1 , ACAN , <t>MATN1</t> , CYTL1 , COL1A1 , SFRP2 , HHIP , VEGFA , GDF5 , PIEZO2 , and ADGRG6 on UMAP. C) Representative IHC images of MATN1 (upper) and POSTN (lower) in human axial skeleton sections at the indicated developmental stages. Asterisks indicate AF. Scale bar, 200 µm. D) Heatmap revealing binary regulon activities analyzed with SCENIC in each vertebral chondrocyte subpopulation. “ON” indicates active regulons, and “OFF” indicates inactive regulons. E) Representative fluorescent images of the Ccn2‐GFP mouse IVD section at P0. OAF, outer annulus fibrosus; IAF, inner annulus fibrosus; VB, vertebral body; EP, end plate; NP, nucleus pulposus. Scale bar, 200 µm. F) Violin plot showing the expression of stem/progenitor markers, including THY1 , PDPN , CD164 , PDGFRB , MCAM , and CTSK . G) Monocle pseudotime trajectory axis revealing the progression of human vertebral chondrocytes. ECO, endochondral ossification; EP/IAF, end plate/inner annulus fibrosus. H) Expression of selected differentially expressed genes for each branch. The cells were ordered in pseudotime analyzed with Monocle and colored in developmental stages. The full line represents the ECO, while the dotted line represents the EP/IAF. ECO, endochondral ossification; EP/IAF, end plate/inner annulus fibrosus.
    Matn1, supplied by Bioss, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/matn1/product/Bioss
    Average 93 stars, based on 1 article reviews
    matn1 - by Bioz Stars, 2026-02
    93/100 stars

    Images

    1) Product Images from "Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution"

    Article Title: Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution

    Journal: Advanced Science

    doi: 10.1002/advs.202206296

    Characterization of vertebral chondrocytes during early IVD formation. A) UMAP visualization (upper) of the four vertebral chondrocyte subclusters defined during human early IVD formation at the Noto, Trans, and NPL stages (lower). B) UMAP plots and violin plots showing the expressions of MATN4 , COL2A1 , ACAN , MATN1 , CYTL1 , COL1A1 , SFRP2 , HHIP , VEGFA , GDF5 , PIEZO2 , and ADGRG6 on UMAP. C) Representative IHC images of MATN1 (upper) and POSTN (lower) in human axial skeleton sections at the indicated developmental stages. Asterisks indicate AF. Scale bar, 200 µm. D) Heatmap revealing binary regulon activities analyzed with SCENIC in each vertebral chondrocyte subpopulation. “ON” indicates active regulons, and “OFF” indicates inactive regulons. E) Representative fluorescent images of the Ccn2‐GFP mouse IVD section at P0. OAF, outer annulus fibrosus; IAF, inner annulus fibrosus; VB, vertebral body; EP, end plate; NP, nucleus pulposus. Scale bar, 200 µm. F) Violin plot showing the expression of stem/progenitor markers, including THY1 , PDPN , CD164 , PDGFRB , MCAM , and CTSK . G) Monocle pseudotime trajectory axis revealing the progression of human vertebral chondrocytes. ECO, endochondral ossification; EP/IAF, end plate/inner annulus fibrosus. H) Expression of selected differentially expressed genes for each branch. The cells were ordered in pseudotime analyzed with Monocle and colored in developmental stages. The full line represents the ECO, while the dotted line represents the EP/IAF. ECO, endochondral ossification; EP/IAF, end plate/inner annulus fibrosus.
    Figure Legend Snippet: Characterization of vertebral chondrocytes during early IVD formation. A) UMAP visualization (upper) of the four vertebral chondrocyte subclusters defined during human early IVD formation at the Noto, Trans, and NPL stages (lower). B) UMAP plots and violin plots showing the expressions of MATN4 , COL2A1 , ACAN , MATN1 , CYTL1 , COL1A1 , SFRP2 , HHIP , VEGFA , GDF5 , PIEZO2 , and ADGRG6 on UMAP. C) Representative IHC images of MATN1 (upper) and POSTN (lower) in human axial skeleton sections at the indicated developmental stages. Asterisks indicate AF. Scale bar, 200 µm. D) Heatmap revealing binary regulon activities analyzed with SCENIC in each vertebral chondrocyte subpopulation. “ON” indicates active regulons, and “OFF” indicates inactive regulons. E) Representative fluorescent images of the Ccn2‐GFP mouse IVD section at P0. OAF, outer annulus fibrosus; IAF, inner annulus fibrosus; VB, vertebral body; EP, end plate; NP, nucleus pulposus. Scale bar, 200 µm. F) Violin plot showing the expression of stem/progenitor markers, including THY1 , PDPN , CD164 , PDGFRB , MCAM , and CTSK . G) Monocle pseudotime trajectory axis revealing the progression of human vertebral chondrocytes. ECO, endochondral ossification; EP/IAF, end plate/inner annulus fibrosus. H) Expression of selected differentially expressed genes for each branch. The cells were ordered in pseudotime analyzed with Monocle and colored in developmental stages. The full line represents the ECO, while the dotted line represents the EP/IAF. ECO, endochondral ossification; EP/IAF, end plate/inner annulus fibrosus.

    Techniques Used: Expressing



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    matn1  (Bioss)
    93
    Bioss matn1
    Characterization of vertebral chondrocytes during early IVD formation. A) UMAP visualization (upper) of the four vertebral chondrocyte subclusters defined during human early IVD formation at the Noto, Trans, and NPL stages (lower). B) UMAP plots and violin plots showing the expressions of MATN4 , COL2A1 , ACAN , <t>MATN1</t> , CYTL1 , COL1A1 , SFRP2 , HHIP , VEGFA , GDF5 , PIEZO2 , and ADGRG6 on UMAP. C) Representative IHC images of MATN1 (upper) and POSTN (lower) in human axial skeleton sections at the indicated developmental stages. Asterisks indicate AF. Scale bar, 200 µm. D) Heatmap revealing binary regulon activities analyzed with SCENIC in each vertebral chondrocyte subpopulation. “ON” indicates active regulons, and “OFF” indicates inactive regulons. E) Representative fluorescent images of the Ccn2‐GFP mouse IVD section at P0. OAF, outer annulus fibrosus; IAF, inner annulus fibrosus; VB, vertebral body; EP, end plate; NP, nucleus pulposus. Scale bar, 200 µm. F) Violin plot showing the expression of stem/progenitor markers, including THY1 , PDPN , CD164 , PDGFRB , MCAM , and CTSK . G) Monocle pseudotime trajectory axis revealing the progression of human vertebral chondrocytes. ECO, endochondral ossification; EP/IAF, end plate/inner annulus fibrosus. H) Expression of selected differentially expressed genes for each branch. The cells were ordered in pseudotime analyzed with Monocle and colored in developmental stages. The full line represents the ECO, while the dotted line represents the EP/IAF. ECO, endochondral ossification; EP/IAF, end plate/inner annulus fibrosus.
    Matn1, supplied by Bioss, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/matn1/product/Bioss
    Average 93 stars, based on 1 article reviews
    matn1 - by Bioz Stars, 2026-02
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    Characterization of vertebral chondrocytes during early IVD formation. A) UMAP visualization (upper) of the four vertebral chondrocyte subclusters defined during human early IVD formation at the Noto, Trans, and NPL stages (lower). B) UMAP plots and violin plots showing the expressions of MATN4 , COL2A1 , ACAN , MATN1 , CYTL1 , COL1A1 , SFRP2 , HHIP , VEGFA , GDF5 , PIEZO2 , and ADGRG6 on UMAP. C) Representative IHC images of MATN1 (upper) and POSTN (lower) in human axial skeleton sections at the indicated developmental stages. Asterisks indicate AF. Scale bar, 200 µm. D) Heatmap revealing binary regulon activities analyzed with SCENIC in each vertebral chondrocyte subpopulation. “ON” indicates active regulons, and “OFF” indicates inactive regulons. E) Representative fluorescent images of the Ccn2‐GFP mouse IVD section at P0. OAF, outer annulus fibrosus; IAF, inner annulus fibrosus; VB, vertebral body; EP, end plate; NP, nucleus pulposus. Scale bar, 200 µm. F) Violin plot showing the expression of stem/progenitor markers, including THY1 , PDPN , CD164 , PDGFRB , MCAM , and CTSK . G) Monocle pseudotime trajectory axis revealing the progression of human vertebral chondrocytes. ECO, endochondral ossification; EP/IAF, end plate/inner annulus fibrosus. H) Expression of selected differentially expressed genes for each branch. The cells were ordered in pseudotime analyzed with Monocle and colored in developmental stages. The full line represents the ECO, while the dotted line represents the EP/IAF. ECO, endochondral ossification; EP/IAF, end plate/inner annulus fibrosus.

    Journal: Advanced Science

    Article Title: Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution

    doi: 10.1002/advs.202206296

    Figure Lengend Snippet: Characterization of vertebral chondrocytes during early IVD formation. A) UMAP visualization (upper) of the four vertebral chondrocyte subclusters defined during human early IVD formation at the Noto, Trans, and NPL stages (lower). B) UMAP plots and violin plots showing the expressions of MATN4 , COL2A1 , ACAN , MATN1 , CYTL1 , COL1A1 , SFRP2 , HHIP , VEGFA , GDF5 , PIEZO2 , and ADGRG6 on UMAP. C) Representative IHC images of MATN1 (upper) and POSTN (lower) in human axial skeleton sections at the indicated developmental stages. Asterisks indicate AF. Scale bar, 200 µm. D) Heatmap revealing binary regulon activities analyzed with SCENIC in each vertebral chondrocyte subpopulation. “ON” indicates active regulons, and “OFF” indicates inactive regulons. E) Representative fluorescent images of the Ccn2‐GFP mouse IVD section at P0. OAF, outer annulus fibrosus; IAF, inner annulus fibrosus; VB, vertebral body; EP, end plate; NP, nucleus pulposus. Scale bar, 200 µm. F) Violin plot showing the expression of stem/progenitor markers, including THY1 , PDPN , CD164 , PDGFRB , MCAM , and CTSK . G) Monocle pseudotime trajectory axis revealing the progression of human vertebral chondrocytes. ECO, endochondral ossification; EP/IAF, end plate/inner annulus fibrosus. H) Expression of selected differentially expressed genes for each branch. The cells were ordered in pseudotime analyzed with Monocle and colored in developmental stages. The full line represents the ECO, while the dotted line represents the EP/IAF. ECO, endochondral ossification; EP/IAF, end plate/inner annulus fibrosus.

    Article Snippet: The sections were incubated with primary antibodies against KRT8 (1:500, #ab53280; Abcam, Cambridge, UK), SOX10 (1:200, #ab155279; Abcam), ACAN (1:500, #ab36861; Abcam), COL1A1 (1:250, #AF7001; Affinity Biosciences, Cincinnati, OH, USA), CTSK (1:200, #ab19027; Abcam), MATN1 (1:200, #bs‐1976R; Bioss Antibodies, Woburn, MA), POSTN (1:500, #66491‐1‐Ig; Proteintech Corp., Rosemont, IL), TAGLN (1:200, #AF9266; Affinity Biosciences), FMOD (1:200, #60108‐1‐Ig; Proteintech Corp.), SPP1 (1:500, #b69498; Abcam), VEGFA (1:200, #66828‐1‐Ig; Proteintech Corp.), SOX9 (1:500, #ab185966; Abcam), and COL10A1 (1:400, #ab49945; Abcam) at 4 °C overnight.

    Techniques: Expressing