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bms195614 rara antagonist tocris  (Tocris)


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    Tocris bms195614 rara antagonist tocris
    Bms195614 Rara Antagonist Tocris, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 35 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bms195614/BMS+195614/pm39571575-227-36-39
    Average 92 stars, based on 35 article reviews
    bms195614 rara antagonist tocris - by Bioz Stars, 2026-10
    92/100 stars

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    other:

    Article Title: Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists
    Article Snippet: On the day of the experiment, cells are homogenized using Accumax (EMD Millipore), counted, and adjusted to 40,000 cells/ml for breast cancer lines and 60,000 cells/mL for AML in appropriate growth media.

    Article Title: Anti-inflammatory Action of BT75, a Novel RARα Agonist, in Cultured Microglia and in an Experimental Mouse Model of Alzheimer's Disease.
    Article Snippet: BT75, a boron-containing retinoid, is a novel retinoic acid receptor (RAR)α agonist synthesized by our group.. Previous studies indicated that activation of retinoic acid (RA) signaling may attenuate progression of Alzheimer’s disease (AD).. Presently, we aimed to examine the anti-inflammatory effect of BT75 and explore the possible mechanism using cultured cells and an AD mouse model. Pretreatment with BT75 (1–25 μM) suppressed the release of nitric oxide (NO) and IL-1β in the culture medium of mouse microglial SIM-A9 cells activated by LPS.

    Control:

    Article Title: Aldh inhibitor restores auditory function in a mouse model of human deafness
    Article Snippet: Cochlear explants were cultured on 35mm dish coated with collagen I (BD Biosciences, USA), in serum-free 1:1 mixture of DMEM and F12, supplemented with Glutamax, N2, B27 supplements and Penicillin G (all from Gibco, USA). .. After 24 h, 100 μM 4-Diethylaminobenzaldehyde (DEAB, Sigma, USA), 5 μM BMS195614 (Tocris Bioscience, UK) or 0.3 μM all-trans retinoic acid (RA, Sigma, USA) or DMSO vehicle control were added to the culture medium for 5 days with fresh drug-containing media replaced every 2 days. .. Cultured cochlear explants or isolated whole cochleae were homogenized and total RNA was extracted from tissues with the RNAiso Plus kit (TaKaRa, Japan).

    Injection:

    Article Title: Abstracts—Posters
    Article Snippet: Chronic, excessive alcohol intake can lead to dynamic changes in stress-related behaviors and neural mechanisms.. We aim to explore how long-term intermittent alcohol (IA) changes howmice react to a variety of stressors and if the dynorphin (DYN)/kappa opioid receptor (KOR) system influences these aberrant behaviors.. After six weeks of IA, C57BL/6J mice show reduced ability to cope with repeated forced swim stress and deficits in avoidance and burying in response to TMT predator odor compared to H2O-drinking mice.



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    Effect of RAR α , RXR α agonist, or antagonist on NF- κ B/AP-1 activity of THP-1 cells upon flagellin challenge. To determine RAR/RXR agonist effects, THP1-XBlue cells were treated with 1 μ M RAR α agonist BMS753 (a) or 1 μ M RXR α agonist LG100268 (b) for 24 h and then treated with different concentrations of flagellin as indicated above for 24 h to determine RAR/RXR antagonist effects; cells were preincubated with 1 μ M RAR α antagonist <t>BMS195614</t> (a) or RXR α antagonist UVI3003 (b) for 2 h and then treated with 1 μ M ATRA or DMSO for 24 h followed by stimulation with different concentrations of flagellin from S. typhimurium as indicated above for 24 h. Secreted alkaline phosphatase in cell culture supernatants was measured by ELISA to determine NF- κ B/AP-1 activity. Bar graphs indicate relative NF- κ B/AP-1 activity ± SD. Statistical significance was assessed by one-way ANOVA using SPSS. ∗ p < 0.01.
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    Effect of RAR α , RXR α agonist, or antagonist on NF- κ B/AP-1 activity of THP-1 cells upon flagellin challenge. To determine RAR/RXR agonist effects, THP1-XBlue cells were treated with 1 μ M RAR α agonist BMS753 (a) or 1 μ M RXR α agonist LG100268 (b) for 24 h and then treated with different concentrations of flagellin as indicated above for 24 h to determine RAR/RXR antagonist effects; cells were preincubated with 1 μ M RAR α antagonist <t>BMS195614</t> (a) or RXR α antagonist UVI3003 (b) for 2 h and then treated with 1 μ M ATRA or DMSO for 24 h followed by stimulation with different concentrations of flagellin from S. typhimurium as indicated above for 24 h. Secreted alkaline phosphatase in cell culture supernatants was measured by ELISA to determine NF- κ B/AP-1 activity. Bar graphs indicate relative NF- κ B/AP-1 activity ± SD. Statistical significance was assessed by one-way ANOVA using SPSS. ∗ p < 0.01.
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    Reagents and tools table

    Journal: EMBO Reports

    Article Title: Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer

    doi: 10.1038/s44319-024-00335-y

    Figure Lengend Snippet: Reagents and tools table

    Article Snippet: RARα antagonist (BMS195614) , Cayman , 16029.1.

    Techniques: Recombinant, Sequencing, Software

    Effect of RAR α , RXR α agonist, or antagonist on NF- κ B/AP-1 activity of THP-1 cells upon flagellin challenge. To determine RAR/RXR agonist effects, THP1-XBlue cells were treated with 1 μ M RAR α agonist BMS753 (a) or 1 μ M RXR α agonist LG100268 (b) for 24 h and then treated with different concentrations of flagellin as indicated above for 24 h to determine RAR/RXR antagonist effects; cells were preincubated with 1 μ M RAR α antagonist BMS195614 (a) or RXR α antagonist UVI3003 (b) for 2 h and then treated with 1 μ M ATRA or DMSO for 24 h followed by stimulation with different concentrations of flagellin from S. typhimurium as indicated above for 24 h. Secreted alkaline phosphatase in cell culture supernatants was measured by ELISA to determine NF- κ B/AP-1 activity. Bar graphs indicate relative NF- κ B/AP-1 activity ± SD. Statistical significance was assessed by one-way ANOVA using SPSS. ∗ p < 0.01.

    Journal: BioMed Research International

    Article Title: All-Trans Retinoic Acid Enhances Bacterial Flagellin-Stimulated Proinflammatory Responses in Human Monocyte THP-1 Cells by Upregulating CD14

    doi: 10.1155/2019/8059312

    Figure Lengend Snippet: Effect of RAR α , RXR α agonist, or antagonist on NF- κ B/AP-1 activity of THP-1 cells upon flagellin challenge. To determine RAR/RXR agonist effects, THP1-XBlue cells were treated with 1 μ M RAR α agonist BMS753 (a) or 1 μ M RXR α agonist LG100268 (b) for 24 h and then treated with different concentrations of flagellin as indicated above for 24 h to determine RAR/RXR antagonist effects; cells were preincubated with 1 μ M RAR α antagonist BMS195614 (a) or RXR α antagonist UVI3003 (b) for 2 h and then treated with 1 μ M ATRA or DMSO for 24 h followed by stimulation with different concentrations of flagellin from S. typhimurium as indicated above for 24 h. Secreted alkaline phosphatase in cell culture supernatants was measured by ELISA to determine NF- κ B/AP-1 activity. Bar graphs indicate relative NF- κ B/AP-1 activity ± SD. Statistical significance was assessed by one-way ANOVA using SPSS. ∗ p < 0.01.

    Article Snippet: To determine antagonist effects, RAR α antagonist BMS195614 (Sigma-Aldrich) and RXR α antagonist UVI 3003 (Santa Cruz Biotechnology, Dallas, Texas, USA) were used.

    Techniques: Activity Assay, Cell Culture, Enzyme-linked Immunosorbent Assay