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bmp4 agonist sb4  (MedChemExpress)


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    MedChemExpress bmp4 agonist sb4
    Bmp4 Agonist Sb4, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bmp4/BMP+signaling+agonist+sb4/10__1172_slash_jci207031-244-16-20
    Average 94 stars, based on 11 article reviews
    bmp4 agonist sb4 - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Recombinant:

    Article Title: POSTN + fibroblast-secreted small extracellular vesicles drive macrophage M2 polarization through BMP4/BMPR2/Smad signaling
    Article Snippet: The human monocytic leukemia cell line THP-1 was grown in a T25 culture flask supplemented with RPMI 1640 medium(Gibco; Thermo Fisher Scientific, Inc.) containing 50 ng/ml of phorbol 12-myristate 13-acetate (PMA; cat. no. P8139; Sigma-Aldrich; Merck KGaA) for 48 h. Then, they were maintained in fresh RPMI 1640 culture medium for 24 h to stabilize their growth. .. To confirm that BMP4 promotes macrophage polarization toward the M2 phenotype, THP-1 (2×10 6 cells) were seeded in 6-well plates and differentiated into macrophages using 50 ng/ml PMA for 48 h. After stabilization, macrophages were assigned to different groups and then either left unstimulated or stimulated for an additional 48 h with recombinant human BMP4 (50 or 100 ng/ml; cat. no. HY-P7007; MedChemExpress). .. Macrophages were stained with FITC anti-human CD163 antibody (cat. no. 333617; 1:50; Biolegend Inc.) and FITC anti-human CD206 antibody (cat. no. 321103; 1:50; Biolegend Inc.) at 4°C for 15 min and then centrifugation 1,000 × g at 4°C for 5 min. Pellets were resuspended in 1 ml PBS and analyzed the expression of M2 macrophage polarization biomarkers (CD163 and CD206) was then analyzed by Flow cytometry (NovoCyte 2040R; ACEA Biosciences) equipped with NovoExpress software (version 1.6.3; http://explore.agilent.com/ACEA-joins-Agilent ).

    Article Title: Transcriptomics and Metabolomics Insights into the Dysregulation of Chondrocyte Differentiation Induced by T-2 Toxin
    Article Snippet: .. In brief, ATDC5 cells were induced to differentiate at various time points (days 3, 7, 14, and 21) with exposure to T-2 toxin alone, or in combination with BMP2 (HY-P7006, MedChemExpress, Monmouth Junction, NJ, USA), BMP4 (HY- P74379 , MedChemExpress), or both recombinant proteins. ..

    Single Cell:

    Article Title: FOXO1-driven endothelial senescence in bicuspid aortic valve-associated thoracic aortic aneurysm.
    Article Snippet: Bicuspid aortic valve (BAV) is a congenital malformation that predisposes individuals to thoracic aortic aneurysm (TAA), with endothelial dysfunction playing a pivotal role in its pathogenesis.. Endothelial cell senescence is a hallmark of endothelial dysfunction, yet direct evidence linking endothelial senescence to BAV-TAA has not been established.. In this study, we generated induced pluripotent stem cells (iPSCs) from both BAV-TAA patients and healthy controls, subsequently differentiating them into endothelial cells (iECs).



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    bmp4 agonist sb4  (MedChemExpress)
    94
    MedChemExpress bmp4 agonist sb4
    Bmp4 Agonist Sb4, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bmp4/BMP+signaling+agonist+sb4/10__1172_slash_jci207031-244-16-20
    Average 94 stars, based on 1 article reviews
    bmp4 agonist sb4 - by Bioz Stars, 2026-09
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    bmp4  (Miltenyi Biotec)
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    Miltenyi Biotec bmp4
    Signaling factors required for generation of human ARC in vitro (A) Hypothalamic development in vivo and in vitro differentiation of hPSC into hypothalamic cells. (B) Principal-component analysis (PCA) of day 16 RT-qPCR data (RC17), clustering according to ARC- and PVN-associated genes. Each dot represents one differentiation batch ( n = 113). (C) Estimated marginal means assessing the effect of factors on PC1, adjusted for covariates. (D) ICC/ISH at days 16 and 50 for ARC protocol with or without <t>BMP4.</t> Scale bars: 100 μm. (E) ARC differentiation protocol and maturation options. (F–H) ICC of day 50 in 2D (F) and 3D (G and H), scale bars: 50 and 100 μm. (I) Quantification of day 50 3D spheroids (AGRP: n = 14, 4.53% ± 0.69%, mean ± SEM; αMSH: n = 6, 5.90% ± 1.19%). (J) Xenotransplantation of day 16 ARC progenitors into nude rats. (J′) Top: ICC for human neural cell adhesion molecule (NCAM) highlights graft site, scale bar: 2 mm. Bottom: IF for human nuclear antigen (HuNu), scale bar: 200 μm. (K–Q) IF for ARC neuronal markers in grafts. Scale bars: 100 μm (K and O), 50 μm (N), 25 μm (L, M, P, and Q).
    Bmp4, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bmp4/Human+BMP-4%2C+research+grade/pmc13353052-63-0-2
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    bmp4 phc9531  (Thermo Fisher)
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    Signaling factors required for generation of human ARC in vitro (A) Hypothalamic development in vivo and in vitro differentiation of hPSC into hypothalamic cells. (B) Principal-component analysis (PCA) of day 16 RT-qPCR data (RC17), clustering according to ARC- and PVN-associated genes. Each dot represents one differentiation batch ( n = 113). (C) Estimated marginal means assessing the effect of factors on PC1, adjusted for covariates. (D) ICC/ISH at days 16 and 50 for ARC protocol with or without <t>BMP4.</t> Scale bars: 100 μm. (E) ARC differentiation protocol and maturation options. (F–H) ICC of day 50 in 2D (F) and 3D (G and H), scale bars: 50 and 100 μm. (I) Quantification of day 50 3D spheroids (AGRP: n = 14, 4.53% ± 0.69%, mean ± SEM; αMSH: n = 6, 5.90% ± 1.19%). (J) Xenotransplantation of day 16 ARC progenitors into nude rats. (J′) Top: ICC for human neural cell adhesion molecule (NCAM) highlights graft site, scale bar: 2 mm. Bottom: IF for human nuclear antigen (HuNu), scale bar: 200 μm. (K–Q) IF for ARC neuronal markers in grafts. Scale bars: 100 μm (K and O), 50 μm (N), 25 μm (L, M, P, and Q).
    Bmp4 Phc9531, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bmp4/L(%2B)-Ascorbic+Acid%2C+99%25/10__1002_slash_adfm__75773-271-24-26
    Average 97 stars, based on 1 article reviews
    bmp4 phc9531 - by Bioz Stars, 2026-09
    97/100 stars
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    human bmp-4  (Qkine Ltd)
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    Qkine Ltd human bmp-4
    Signaling factors required for generation of human ARC in vitro (A) Hypothalamic development in vivo and in vitro differentiation of hPSC into hypothalamic cells. (B) Principal-component analysis (PCA) of day 16 RT-qPCR data (RC17), clustering according to ARC- and PVN-associated genes. Each dot represents one differentiation batch ( n = 113). (C) Estimated marginal means assessing the effect of factors on PC1, adjusted for covariates. (D) ICC/ISH at days 16 and 50 for ARC protocol with or without <t>BMP4.</t> Scale bars: 100 μm. (E) ARC differentiation protocol and maturation options. (F–H) ICC of day 50 in 2D (F) and 3D (G and H), scale bars: 50 and 100 μm. (I) Quantification of day 50 3D spheroids (AGRP: n = 14, 4.53% ± 0.69%, mean ± SEM; αMSH: n = 6, 5.90% ± 1.19%). (J) Xenotransplantation of day 16 ARC progenitors into nude rats. (J′) Top: ICC for human neural cell adhesion molecule (NCAM) highlights graft site, scale bar: 2 mm. Bottom: IF for human nuclear antigen (HuNu), scale bar: 200 μm. (K–Q) IF for ARC neuronal markers in grafts. Scale bars: 100 μm (K and O), 50 μm (N), 25 μm (L, M, P, and Q).
    Human Bmp 4, supplied by Qkine Ltd, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bmp4/human+BMP-4/custom%40qk038%4010%2E64898%2F2026%2E06%2E30%2E735652
    Average 94 stars, based on 1 article reviews
    human bmp-4 - by Bioz Stars, 2026-09
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    recombinant human bmp4  (R&D Systems)
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    R&D Systems recombinant human bmp4
    Signaling factors required for generation of human ARC in vitro (A) Hypothalamic development in vivo and in vitro differentiation of hPSC into hypothalamic cells. (B) Principal-component analysis (PCA) of day 16 RT-qPCR data (RC17), clustering according to ARC- and PVN-associated genes. Each dot represents one differentiation batch ( n = 113). (C) Estimated marginal means assessing the effect of factors on PC1, adjusted for covariates. (D) ICC/ISH at days 16 and 50 for ARC protocol with or without <t>BMP4.</t> Scale bars: 100 μm. (E) ARC differentiation protocol and maturation options. (F–H) ICC of day 50 in 2D (F) and 3D (G and H), scale bars: 50 and 100 μm. (I) Quantification of day 50 3D spheroids (AGRP: n = 14, 4.53% ± 0.69%, mean ± SEM; αMSH: n = 6, 5.90% ± 1.19%). (J) Xenotransplantation of day 16 ARC progenitors into nude rats. (J′) Top: ICC for human neural cell adhesion molecule (NCAM) highlights graft site, scale bar: 2 mm. Bottom: IF for human nuclear antigen (HuNu), scale bar: 200 μm. (K–Q) IF for ARC neuronal markers in grafts. Scale bars: 100 μm (K and O), 50 μm (N), 25 μm (L, M, P, and Q).
    Recombinant Human Bmp4, supplied by R&D Systems, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bmp4/Recombinant+Human+BMP-4+Protein/pm42014719-310-33-36
    Average 97 stars, based on 1 article reviews
    recombinant human bmp4 - by Bioz Stars, 2026-09
    97/100 stars
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    bmp4  (R&D Systems)
    97
    R&D Systems bmp4
    Signaling factors required for generation of human ARC in vitro (A) Hypothalamic development in vivo and in vitro differentiation of hPSC into hypothalamic cells. (B) Principal-component analysis (PCA) of day 16 RT-qPCR data (RC17), clustering according to ARC- and PVN-associated genes. Each dot represents one differentiation batch ( n = 113). (C) Estimated marginal means assessing the effect of factors on PC1, adjusted for covariates. (D) ICC/ISH at days 16 and 50 for ARC protocol with or without <t>BMP4.</t> Scale bars: 100 μm. (E) ARC differentiation protocol and maturation options. (F–H) ICC of day 50 in 2D (F) and 3D (G and H), scale bars: 50 and 100 μm. (I) Quantification of day 50 3D spheroids (AGRP: n = 14, 4.53% ± 0.69%, mean ± SEM; αMSH: n = 6, 5.90% ± 1.19%). (J) Xenotransplantation of day 16 ARC progenitors into nude rats. (J′) Top: ICC for human neural cell adhesion molecule (NCAM) highlights graft site, scale bar: 2 mm. Bottom: IF for human nuclear antigen (HuNu), scale bar: 200 μm. (K–Q) IF for ARC neuronal markers in grafts. Scale bars: 100 μm (K and O), 50 μm (N), 25 μm (L, M, P, and Q).
    Bmp4, supplied by R&D Systems, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 97 stars, based on 1 article reviews
    bmp4 - by Bioz Stars, 2026-09
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    human bmp4  (R&D Systems)
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    R&D Systems human bmp4
    Signaling factors required for generation of human ARC in vitro (A) Hypothalamic development in vivo and in vitro differentiation of hPSC into hypothalamic cells. (B) Principal-component analysis (PCA) of day 16 RT-qPCR data (RC17), clustering according to ARC- and PVN-associated genes. Each dot represents one differentiation batch ( n = 113). (C) Estimated marginal means assessing the effect of factors on PC1, adjusted for covariates. (D) ICC/ISH at days 16 and 50 for ARC protocol with or without <t>BMP4.</t> Scale bars: 100 μm. (E) ARC differentiation protocol and maturation options. (F–H) ICC of day 50 in 2D (F) and 3D (G and H), scale bars: 50 and 100 μm. (I) Quantification of day 50 3D spheroids (AGRP: n = 14, 4.53% ± 0.69%, mean ± SEM; αMSH: n = 6, 5.90% ± 1.19%). (J) Xenotransplantation of day 16 ARC progenitors into nude rats. (J′) Top: ICC for human neural cell adhesion molecule (NCAM) highlights graft site, scale bar: 2 mm. Bottom: IF for human nuclear antigen (HuNu), scale bar: 200 μm. (K–Q) IF for ARC neuronal markers in grafts. Scale bars: 100 μm (K and O), 50 μm (N), 25 μm (L, M, P, and Q).
    Human Bmp4, supplied by R&D Systems, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bmp4/Recombinant+Human+BMP-4+Protein/pm41986309-141-30-32
    Average 97 stars, based on 1 article reviews
    human bmp4 - by Bioz Stars, 2026-09
    97/100 stars
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    Image Search Results


    Signaling factors required for generation of human ARC in vitro (A) Hypothalamic development in vivo and in vitro differentiation of hPSC into hypothalamic cells. (B) Principal-component analysis (PCA) of day 16 RT-qPCR data (RC17), clustering according to ARC- and PVN-associated genes. Each dot represents one differentiation batch ( n = 113). (C) Estimated marginal means assessing the effect of factors on PC1, adjusted for covariates. (D) ICC/ISH at days 16 and 50 for ARC protocol with or without BMP4. Scale bars: 100 μm. (E) ARC differentiation protocol and maturation options. (F–H) ICC of day 50 in 2D (F) and 3D (G and H), scale bars: 50 and 100 μm. (I) Quantification of day 50 3D spheroids (AGRP: n = 14, 4.53% ± 0.69%, mean ± SEM; αMSH: n = 6, 5.90% ± 1.19%). (J) Xenotransplantation of day 16 ARC progenitors into nude rats. (J′) Top: ICC for human neural cell adhesion molecule (NCAM) highlights graft site, scale bar: 2 mm. Bottom: IF for human nuclear antigen (HuNu), scale bar: 200 μm. (K–Q) IF for ARC neuronal markers in grafts. Scale bars: 100 μm (K and O), 50 μm (N), 25 μm (L, M, P, and Q).

    Journal: Cell Stem Cell

    Article Title: Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells

    doi: 10.1016/j.stem.2026.05.005

    Figure Lengend Snippet: Signaling factors required for generation of human ARC in vitro (A) Hypothalamic development in vivo and in vitro differentiation of hPSC into hypothalamic cells. (B) Principal-component analysis (PCA) of day 16 RT-qPCR data (RC17), clustering according to ARC- and PVN-associated genes. Each dot represents one differentiation batch ( n = 113). (C) Estimated marginal means assessing the effect of factors on PC1, adjusted for covariates. (D) ICC/ISH at days 16 and 50 for ARC protocol with or without BMP4. Scale bars: 100 μm. (E) ARC differentiation protocol and maturation options. (F–H) ICC of day 50 in 2D (F) and 3D (G and H), scale bars: 50 and 100 μm. (I) Quantification of day 50 3D spheroids (AGRP: n = 14, 4.53% ± 0.69%, mean ± SEM; αMSH: n = 6, 5.90% ± 1.19%). (J) Xenotransplantation of day 16 ARC progenitors into nude rats. (J′) Top: ICC for human neural cell adhesion molecule (NCAM) highlights graft site, scale bar: 2 mm. Bottom: IF for human nuclear antigen (HuNu), scale bar: 200 μm. (K–Q) IF for ARC neuronal markers in grafts. Scale bars: 100 μm (K and O), 50 μm (N), 25 μm (L, M, P, and Q).

    Article Snippet: BMP4 , Miltenyi Biotec , Cat#130-111-168.

    Techniques: In Vitro, In Vivo, Quantitative RT-PCR

    Duration of BMP stimulation controls ARC versus VMH identity (A) BMP signaling in the developing chick tuberal hypothalamus. Adapted from Chinnaiya et al. vFB, ventral forebrain. (B) Experimental design to simulate BMP withdrawal. (C) ICC/ISH for days 16 and 50 across BMP4 withdrawal conditions. Scale bar: 100 μm. (D) Day 16 RT-qPCR (RC17, KOLF2.1J, BIONi010) across BMP4 withdrawal conditions. Mean ± SEM, Kruskal-Wallis with Dunn’s multiple comparisons test: FGF10 : −BMP versus days 5–14 p < 0.0001; days 5–7 versus days 5–14 p < 0.0001; days 5–9 versus days 5–14 p = 0.0040; days 5–11 versus days 5–14 p = 0.013; SOX14 : −BMP versus days 5–14 p < 0.0001; days 5–7 versus days 5–14 p = 0.0004; days 5–9 versus days 5–14 p = 0.0011; days 5–11 versus days 5–14 p = 0.0020. (E) Day 50 RT-qPCR (RC17, KOLF2.1J, BIONi010) across BMP4 withdrawal conditions. Mean ± SEM, Kruskal-Wallis with Dunn’s test: AGRP : −BMP versus days 5–14 p = 0.0080; days 5–7 versus days 5–14 p = 0.0269 NR5A1 : −BMP versus days 5–14 p = 0.0016; days 5–7 versus days 5–14 p = 0.0162. (F and G) UMAPs of day 16 (F) and days 50 + 80 + 110 (G) snRNA-seq ( n = 3; RC17, KOLF2.1J, BIONi010) and annotated clusters with proportional representation. ARC- and VMH-specific clusters are marked with a box. (H) Spatial projection probability of days 50 + 80 + 110 clusters onto human adult reference. (I) 3D staining for Wisteria floribunda agglutinin (WFA), scale bar: 100 μm.

    Journal: Cell Stem Cell

    Article Title: Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells

    doi: 10.1016/j.stem.2026.05.005

    Figure Lengend Snippet: Duration of BMP stimulation controls ARC versus VMH identity (A) BMP signaling in the developing chick tuberal hypothalamus. Adapted from Chinnaiya et al. vFB, ventral forebrain. (B) Experimental design to simulate BMP withdrawal. (C) ICC/ISH for days 16 and 50 across BMP4 withdrawal conditions. Scale bar: 100 μm. (D) Day 16 RT-qPCR (RC17, KOLF2.1J, BIONi010) across BMP4 withdrawal conditions. Mean ± SEM, Kruskal-Wallis with Dunn’s multiple comparisons test: FGF10 : −BMP versus days 5–14 p < 0.0001; days 5–7 versus days 5–14 p < 0.0001; days 5–9 versus days 5–14 p = 0.0040; days 5–11 versus days 5–14 p = 0.013; SOX14 : −BMP versus days 5–14 p < 0.0001; days 5–7 versus days 5–14 p = 0.0004; days 5–9 versus days 5–14 p = 0.0011; days 5–11 versus days 5–14 p = 0.0020. (E) Day 50 RT-qPCR (RC17, KOLF2.1J, BIONi010) across BMP4 withdrawal conditions. Mean ± SEM, Kruskal-Wallis with Dunn’s test: AGRP : −BMP versus days 5–14 p = 0.0080; days 5–7 versus days 5–14 p = 0.0269 NR5A1 : −BMP versus days 5–14 p = 0.0016; days 5–7 versus days 5–14 p = 0.0162. (F and G) UMAPs of day 16 (F) and days 50 + 80 + 110 (G) snRNA-seq ( n = 3; RC17, KOLF2.1J, BIONi010) and annotated clusters with proportional representation. ARC- and VMH-specific clusters are marked with a box. (H) Spatial projection probability of days 50 + 80 + 110 clusters onto human adult reference. (I) 3D staining for Wisteria floribunda agglutinin (WFA), scale bar: 100 μm.

    Article Snippet: BMP4 , Miltenyi Biotec , Cat#130-111-168.

    Techniques: Quantitative RT-PCR, Staining

    Different POMC subtypes are dependent on BMP timing (A) UMAP of days 50 + 80 + 110 snRNA-seq data from G with POMC clusters and their % across BMP4 exposure timings. (B) Key marker genes across POMC + ARC and VMH clusters in in vitro dataset and human fetal and adult reference datasets. , , (C) MetaNeighbor cluster similarity analysis comparing in vitro POMC⁺ clusters to hypothalamic reference datasets. , , (D) Expression of ARC/VMH-related markers on spatial transcriptomics reference. (E) DEG between in vitro POMC⁺ subtypes, spatial DEGs from HYPOMAP are highlighted. Benjamini-Hochberg corrected p values. (F) Prediction probabilities from spatial mapping of in vitro POMC clusters to HYPOMAP. (G) Hybridization chain reaction (HCR) of chick embryo heads at HH17 and HH20, n = 7–10. Scale bar: 100 μm.

    Journal: Cell Stem Cell

    Article Title: Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells

    doi: 10.1016/j.stem.2026.05.005

    Figure Lengend Snippet: Different POMC subtypes are dependent on BMP timing (A) UMAP of days 50 + 80 + 110 snRNA-seq data from G with POMC clusters and their % across BMP4 exposure timings. (B) Key marker genes across POMC + ARC and VMH clusters in in vitro dataset and human fetal and adult reference datasets. , , (C) MetaNeighbor cluster similarity analysis comparing in vitro POMC⁺ clusters to hypothalamic reference datasets. , , (D) Expression of ARC/VMH-related markers on spatial transcriptomics reference. (E) DEG between in vitro POMC⁺ subtypes, spatial DEGs from HYPOMAP are highlighted. Benjamini-Hochberg corrected p values. (F) Prediction probabilities from spatial mapping of in vitro POMC clusters to HYPOMAP. (G) Hybridization chain reaction (HCR) of chick embryo heads at HH17 and HH20, n = 7–10. Scale bar: 100 μm.

    Article Snippet: BMP4 , Miltenyi Biotec , Cat#130-111-168.

    Techniques: Marker, In Vitro, Expressing, Spatial Transcriptomics, Hybridization