Journal: Bioactive Materials
Article Title: Living photosynthetic micro/nano-platforms: Engineering unicellular algae for biomedical applications
doi: 10.1016/j.bioactmat.2025.05.023
Figure Lengend Snippet: Algae-based biosystems for ischemic stroke therapies. (a) Coculture of C. reinhardtii enhances the functions of isolated cortical slices, which are reflected by the length, frequency, and amplitude of seizure-like event (SLE) activity. The green region indicates periods of algae exposure, while the red region represents periods of non-oxygen inhalation in the upper panel. (b) The yellow region of the upper panel in (a) was enlarged. Reprinted with permission from Ref. . Copyright 2021 Elsevier. (c) Photosynthetic oxygen production of algae in the brain of Xenopus laevis tadpoles. Oxygen concentrations and nerve spiking were tested under light or dark conditions. Reprinted with permission under a Creative Commons CC BY 4.0 License from Ref. . Copyright 2021 Elsevier. (d) Schematic diagram of algae-based nano-photosynthesis therapies for ischemic stroke. (e,f) Cerebral injection of S. elongatus enhances tissue oxygenation of hypoxic brain tissues and decreases neuron apoptosis. (g,h) Fluoro-Jade C staining results demonstrating algae-based therapy reduces the number of degenerating neurons. (i,j) TTC staining results showing algae-based therapy reduces infarct volumes. (k) mNSS, rotarod test, cylinder test, grid test, and pasta test demonstrating behavioral recovery of algae-based therapy. (l) Angiogenesis-promoting effects of S. elongatus were revealed by CD31 immunofluorescence staining. Reprinted with permission from Ref. . Copyright 2021 American Chemical Society.
Article Snippet: Of note, certain algae species such as Chlamydomonas reinhardtii , Cyanothece sp. (ATCC 51142), and Synechocystis sp. (PCC 6803) could naturally generate hydrogen [ , , , ].
Techniques: Algae, Isolation, Activity Assay, Injection, Staining, Immunofluorescence
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