Journal: Journal of Clinical Microbiology
Article Title: Visualizing Borrelia burgdorferi Infection Using a Small-Molecule Imaging Probe
doi: 10.1128/JCM.02313-20
Figure Lengend Snippet: Structures and elution profiles of GFP-bound Hsp90 homologues with Hsp90 inhibitors ( n = 3). (A) Structures of HtpG inhibitors HS-198 and HS-131. (B) Fluorescent counts of drug-induced GFP-bound B. burgdorferi HtpG elution. (C) Fluorescent counts of drug-induced GFP-bound human Hsp90 elution. (D) Fold change in HS-198-eluted fluorescent counts in B. burgdorferi HtpG, E. coli HtpG, human Hsp90, and T. denticola HtpG normalized to baseline. (E) Fold change in HS-131-eluted fluorescent counts in B. burgdorferi HtpG, E. coli HtpG, human Hsp90, and T. denticola HtpG normalized to baseline.
Article Snippet: B. burgdorferi (strain B31) and Treponema denticola genomic DNAs were obtained from the American Type Culture Collection (Manassas, VA; ATCC 35210 and 35405, respectively).
Techniques: