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Chantest Inc whole-cell patch clamp experiments
Whole Cell Patch Clamp Experiments, supplied by Chantest Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/patch-clamp+experiments/patch+clamp+assay/pmc07527709-376-16-7
Average 90 stars, based on 1 article reviews
whole-cell patch clamp experiments - by Bioz Stars, 2026-09
90/100 stars

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Article Title: α7-Nicotinic acetylcholine receptor inhibition by indinavir
Article Snippet: Objective: This study set out to determine if the human immunodeficiency virus (HIV) protease inhibitor, indinavir, alters responsiveness of α7-nicotinic acetylcholine receptors to acetylcholine.. Design: Treatment with highly active antiretroviral therapy has dramatically reduced development of HIV associated dementia and more severe forms of cognitive impairment.. However, many individuals continue to experience cognitive decline of uncertain etiology.

Article Title: Methods and compositions for modulating β-amyloid/α7-nAChR interactions
Article Snippet: All patch-clamp testing was performed by an independent contract research company, ChanTest (Charles River) in the USA.

Article Title: Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator
Article Snippet: Anesthesiology, V 123 • No 5 1093 November 2015 P ERIOPERATIVE sleep apnea is an epidemic,1 and a critical medical need exists for novel therapeutics to support breathing, maintain pain control, and lower hospital costs for surgical patients with sleep-disordered breathing.. GAL-021 is being developed as a novel breathing control modulator to preserve respiratory drive and protect patients from respiratory impairment due to opioids and other modalities.. Only caffeine, doxapram, and almitrine are currently used clinically as breathing control modulators and, in particular, as respiratory stimulants.

Patch Clamp:

Article Title: Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family
Article Snippet: .. In another set of experiments, performed by Chantest Ltd, UK, EC 50 values were determined in whole-cell patch clamp experiments. ..

Article Title: Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs.
Article Snippet: .. The in vitro effects of the compounds on the human ether-à-gogo-related gene potassium channel current (a surrogate for IKr, the rapidly activating, delayed rectifier cardiac potassium current) expressed in mammalian cells were evaluated at room temperature using the QPatch HT (Sophion Bioscience A/S, Ballerup, Denmark), an automatic parallel patch clamp system (Chantest; Cleveland, Ohio). ..

Article Title: Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors.
Article Snippet: A series of pyrazolylpyrimidine scaffold based Syk inhibitors were synthesized and evaluated for their biological activities and selectivity.. Lead optimization efforts provided compounds with potent Syk inhibition in both enzymatic and TNF-α release assay.. Spleen tyrosine kinase (Syk) is an intracellular non-receptor protein tyrosine kinase that is involved in immunoreceptor signaling events, mainly in B-cell receptor, Fc receptors, integrin and lectin receptors.

In Vitro:

Article Title: Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs.
Article Snippet: .. The in vitro effects of the compounds on the human ether-à-gogo-related gene potassium channel current (a surrogate for IKr, the rapidly activating, delayed rectifier cardiac potassium current) expressed in mammalian cells were evaluated at room temperature using the QPatch HT (Sophion Bioscience A/S, Ballerup, Denmark), an automatic parallel patch clamp system (Chantest; Cleveland, Ohio). ..



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