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multiplex maldi-tof mass spectrometer massarray system  (agena bioscience)


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    agena bioscience multiplex maldi-tof mass spectrometer massarray system
    Multiplex Maldi Tof Mass Spectrometer Massarray System, supplied by agena bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/multiplex+massarray+systems/massarray+4+system/pm29134786-49-9-15
    Average 90 stars, based on 1 article reviews
    multiplex maldi-tof mass spectrometer massarray system - by Bioz Stars, 2026-09
    90/100 stars

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    Article Title: Optimizing proton-pump inhibitor therapy in paediatric eosinophilic esophagitis through CYP2C19 pharmacogenetic testing
    Article Snippet: DNA was extracted via buccal swab for targeted CYP2C19 genotyping using mass spectrometry (MassARRAY MALDI-TOF, Agena BioScience).

    Article Title: 59. What the TERT? - A telomerase reverse transcriptase case study
    Article Snippet: B-lymphoblastic leukemia/lymphoma (B-ALL) includes multiple distinct genetic subtypes.. BCR::ABL1like B-ALL is associated with high-risk disease with alterations impacting cytokine receptors and kinases that drive a gene expression profile which mimics BCR::ABL1 -positive B-ALL.. Given the significant genetic heterogeneity and various methodologies used to identify gene fusions, clinical diagnosis and decision-making for patients with this B-ALL subtype remain challenging.

    Article Title: [The role of polymorphic variants rs11546155 and rs6119534 of the GGT7 gene and risk factors in the development of acute pancreatitis].
    Article Snippet: Глутатион – антиоксидант, обладающий мощными восстановительными и детоксикационными свойствами.. Прогрессирующее снижение запасов глутатиона, наблюдаемое при панкреонекрозе, свидетельствует о недостаточности функционирования системы поддержания его уровня в клетках и использовании его эндогенного резерва.. В этой связи особенно актуально изучение роли генов ферментов метаболизма глутатиона в развитии острого панкреатита (ОП).

    Article Title: NADPH oxidase 5 is a novel susceptibility gene for type 2 diabetes mellitus.
    Article Snippet: The MALDI-TOF MassARRAY 4 system (Agena Bioscience Inc., San Diego, CA, USA) was used for SNP genotyping.

    Article Title: Loss of fragile WWOX gene leads to senescence escape and genome instability.
    Article Snippet: After in vitro transcription using the PCR products as the template and T7 RNA polymerase, uracil-specific cleavage of the RNA transcripts by RNase A was conducted and the sizes of the resulting fragments were determined by MALDI-TOF mass spectrometry (MassARRAY Analyzer, Agena Bioscience, San Diego, CA, USA).

    Article Title: EGFR/CEP7 high polysomy is separate and distinct from EGFR amplification in glioblastoma as determined by fluorescence in situ hybridization
    Article Snippet: Methylation was then detected using either a LightCycler PCR instrument (Roche Diagnostic, Switzerland) or a MassArray MALDI-TOF mass spectrometry (Agena Bioscience, San Diego, CA).

    Article Title: Genetic Interactions of Phase II Xenobiotic-Metabolizing Enzymes GSTO1 and GCLC in Relation to Alcohol Abuse and Psoriasis Risk.
    Article Snippet: Genotyping of the selected polymorphisms was conducted using the MALDI-TOF mass spectrometry iPLEX platform on the MassArray-4 system (Agena Bioscience, Inc., San Diego, CA, USA).

    Mass Spectrometry:

    Article Title: Frequency of Tumor Necrosis Factor-α, Interleukin-6, and Interleukin-10 Gene Polymorphisms in Mexican Patients with Diabetic Retinopathy and Diabetic Kidney Disease.
    Article Snippet: The 4 PCR primer pairs and 4 probes for TNF-α rs361525, TNF-α rs1800629, IL-10 rs1800872, and IL-10 rs1800871 were designed using MassARRAY Assay Design v 3.1 software (Sequenom, Inc., San Diego, CA, USA) with the following design parameters: locus-specific primer sizes between 12 and 30 nucleotides, average sizes of amplicons between 80 and 120 base pairs (bp), an annealing temperature between 45 and 100 ◦C, optimal robustness of 0.8 in loop formation, dimers and false amplification primers, average robustness in dimer formation and false primer extension of 0.5, a spectrometric range of 4 to 10 kDa, a separation distance between SNPs of 15 Da, and a maximum multiplexing number of 8 SNPs. .. The method of MALDI-TOF mass spectrometry (MALDI-TOF MS) of DNA molecules in the format of an iPLEX Assay implemented on the Sequenom MassARRAY4 platform (Agena Bioscience, San Diego, CA, USA) was performed as described by Trifonova et al. [23]. .. Genotyping of the SNPs rs1800629, rs361525, rs1800872, and rs1800871 was performed in a 384-well plate format on the MassARRAY System Analyzer 4.0.163 (Sequenom, San Diego, CA, USA), which combines polymerase chain reaction (PCR) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry technologies (MALDI-TOF MS).



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    Selected amlodipine variants used in the design of  multiplex MassARRAY  panels ( n = 13).

    Journal: Genes

    Article Title: Single Nucleotide Polymorphisms in Amlodipine-Associated Genes and Their Correlation with Blood Pressure Control among South African Adults with Hypertension

    doi: 10.3390/genes13081394

    Figure Lengend Snippet: Selected amlodipine variants used in the design of multiplex MassARRAY panels ( n = 13).

    Article Snippet: Two multiplex MassARRAY systems (Agena Bioscience TM ) were designed and optimised by Inqaba Biotechnical Industries (Pretoria, South Africa) and used for the genotyping of the selected SNPs.

    Techniques: Multiplex Assay